Continuous Measurement and Control of Intraocular Pressure in Normal and Glaucomatous Eyes

正常眼和青光眼眼眼压的连续测量和控制

• 批准号: 9160449
• 负责人: CHRISTOPHER L PASSAGLIA
• 金额: $ 35.81万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9160449
• 关键词: Address; Affect; Anatomy; Animal Disease Models; Animal Model; Animals; Aqueous Humor; Back; Blindness; Brain; Cannulas; Cauterize; Cell Death; Chronic; Data; Devices; Diagnosis; Disease; Drainage procedure; Electrophysiology (science); Etiology; Eye; Eye Injuries; Eye diseases; Failure; Frequencies; Genetic; Glaucoma; Hand; Harvest; Human; Hypertension; Implant; Injection of therapeutic agent; Knowledge; Left; Life; Liquid substance; Measurement; Measures; Methods; Microspheres; Modeling; Monitor; Ocular Hypertension; Pathway interactions; Patients; Perfusion; Physiologic Intraocular Pressure; Physiological; Property; Rattus; Recording of previous events; Recovery; Research; Research Personnel; Resolution; Retina; Retinal; Retinal Ganglion Cells; Risk Factors; Saline; Scientist; Shapes; Signal Transduction; Sorting - Cell Movement; Structure; System; Techniques; Technology; Theft; Time; Tissues; Veins; Vision; Visual; Wireless Technology; anterior chamber; aqueous; experience; ganglion cell; high intraocular pressure; implantable device; implanted sensor; innovation; interest; killings; laser photocoagulation; pressure; programs; research study; response; sensor; success; tonometry; tool; visual information

PROJECT SUMMARY Glaucoma is a leading cause of blindness in the world, affecting over 60 million people. Extensive research has demonstrated that increased intraocular pressure (IOP) results in a progressive loss of ganglion cells that is subsequently expressed as a loss of vision. The exact relationship between the chronic dynamics of IOP and the damage experienced by the eye is still unknown and is the central focus of glaucoma studies across the world. Over the years, scientists have developed several animal models in which a wide variety of methods is used to damage the drainage pathways of the eye so that fluid cannot get out as easily. Such techniques tend to be time consuming, present a low success rate, last permanently, and offer no control over IOP amplitude or dynamics. All of these issues significantly hamper our continued ability to study the causes and effects of the disease. Current technology to monitor IOP is also a limiting factor. Tonometry, the most used technique to measure IOP, yields insufficient data and requires a skilled operator at all times. Implantable sensors have been commercially developed to address the issue but they rely on battery power to function, which limits their operating lifetime and the accuracy of the data collected. This project describes one-of-a-kind wireless implantable devices that are capable of continually measuring and regulating IOP, doing so with high accuracy, near-zero failure rate, and virtually unlimited operational lifetime. For the first time they give the experimenter complete control over the IOP history to which an eye is exposed. This project proposes to use the technology to investigate the response and resiliency of the eye to elevated IOP when fluid drainage pathways are not overtly damaged like in all other animal models of the disease. The specific aims are to systematically and quantitatively assess the effects of experimental glaucoma and this new perfusion-induced hypertension model on: i) IOP variability, ii) ocular fluid dynamics, iii) retinal structure and function, and iv) visual sensitivity of rats.

项目摘要 青光眼是世界上致盲的主要原因，影响超过6000万人。广泛的研究 已经证明眼内压（IOP）升高导致神经节细胞的进行性丧失 随后表现为视力丧失。慢性动力学之间的确切关系 眼压和眼睛所经历的损害仍然是未知的，是青光眼研究的中心焦点 在世界各地。多年来，科学家们已经开发了几种动物模型，其中各种各样的 的方法是用来破坏眼睛的排水通道，使液体不能轻易地出来。等 技术往往是耗时的，目前的成功率低，持久的，并提供没有控制 超过IOP幅度或动态。所有这些问题都严重阻碍了我们继续研究 疾病的原因和影响。目前监测IOP的技术也是一个限制因素。眼压测量， 最常用的测量IOP的技术，产生的数据不足，并且需要熟练的操作者在任何时候。 为了解决这个问题，商业上已经开发了植入式传感器，但它们依赖于电池供电 这限制了它们的使用寿命和所收集数据的准确性。 该项目描述了一种无线植入式设备，能够连续测量 和调节IOP，这样做的精度高，故障率接近零， 辈子这是他们第一次让实验者完全控制眼内压的历史， 暴露了该项目建议使用该技术来调查 当液体引流途径没有像所有其他动物模型中那样明显受损时，眼睛IOP升高 的疾病。具体目标是系统地、定量地评估实验性 青光眼和这种新的灌注诱导的高血压模型：i）IOP变异性，ii）眼流体动力学， iii）视网膜结构和功能，和iv）大鼠的视觉敏感性。