Proton MRI to measure lung ventilation and perfusion

质子 MRI 测量肺通气和灌注

• 批准号: 9096209
• 负责人: GORDON KIM PRISK
• 金额: $ 90.87万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9096209
• 关键词: Address; Affect; Air; Animal Model; Animals; Biological Markers; Biomedical Engineering; Blood flow; Breathing; Chronic Obstructive Airway Disease; Clinical Research; Clinical Trials; Communities; Computer Simulation; Contrast Media; Dimensions; Discipline of Nuclear Medicine; Disease; Dourine; Environmental air flow; Evolution; Exposure to; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Gases; Goals; Gold; Grant; Health; Health Care Research; Healthcare; Heterogeneity; Human; Image; Imaging Techniques; Injection of therapeutic agent; Ionizing radiation; Lung; Lung diseases; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Microspheres; Modeling; Morphologic artifacts; Noble Gases; Pattern; Perfusion; Phenotype; Physiologic pulse; Physiological; Physiology; Property; Protons; Pulmonary Gas Exchange; Radiation; Regional Perfusion; Research; Research Personnel; Research Technics; Resolution; Series; Source Code; Spatial Distribution; Structure; Techniques; Therapeutic Intervention; Time; Universities; Validation; Ventilation-Perfusion Ratio; Washington; X-Ray Computed Tomography; base; clinical application; clinically relevant; computerized data processing; density; foot; imaging modality; improved; lung imaging; pre-clinical; programs; research study; sound; standard measure; tool; validation studies

DESCRIPTION (provided by applicant): In comparison to other imaging modalities such as computerized tomography and nuclear medicine techniques, quantitative functional magnetic resonance imaging (MRI) of the human lung is relatively poorly developed. These MRI techniques are not limited by exposure to ionizing radiation or contrast injection and thus open the door to unlimited repeated studies, and offer the possibility of new fields such as temporal imaging. The long-term objective of this program is to develop and establish quantitative functional proton MRI in the human lung as a readily available means of providing regional information on perfusion, ventilation and gas exchange that is physiologically and clinically relevant. Techniques we have developed allow us to quantitatively measure the spatial distributions of lung density (a direct measure of air content), pulmonary blood flow, and specific ventilation. Together these techniques permit us to quantitatively map ventilation- perfusion ratio (V? A/Q?), which uniquely determines pulmonary gas exchange, with a spatial resolution that is close to the scale of the functional gas exchange unit of the human lung. The overall goal of the first five years of this Bioengineering Research Partnership (BRP) is to make these research techniques translatable to the wider research community so that they may be used as biomarkers in research studies and in clinical trials, with a future goal of clinical applicability To do so, these techniques need to: a) have their physiological interpretation strengthened to provide a rigorous basis for interpretation of the results they produce; b) be further developed into efficient and accessible techniques for clinical studies; and c) be subjected to validation studies to prove their applicability for clinical studies. To these ends we propose a coordinated series of studies that will: 1) use highly anatomically-realistic in-silico modeling to place the physiological interpretation of all imaging modalities on a sound footing; 2) validate imaging of perfusion, ventilation and V A/Q by comparing with injected and inhaled microsphere measurements in a pre-clinical large animal model; 3) cross- validate imaging of V A/Q in humans with quantitative measures of VA/Q obtained from the gold-standard non-imaging approach of the multiple inert gas elimination technique, both in the normal and diseased lung; and 4) optimize the current MR methodology and expand the repertoire of functional lung imaging with improved techniques. Completion of this BRP will result in deliverables of an accessible suite of validated quantitative functional MR lung imaging methods for use on commercially available scanners to measure density, perfusion, ventilation, and ventilation-perfusion ratio.

描述（由申请人提供）：与计算机断层扫描和核医学技术等其他成像方式相比，人类肺部的定量功能磁共振成像（MRI）发展相对较差。这些 MRI 技术不受电离辐射或造影剂注射的限制，从而为无限重复研究打开了大门，并提供了时间成像等新领域的可能性。该计划的长期目标是开发和建立人肺定量功能质子 MRI，作为提供生理和临床相关的灌注、通气和气体交换区域信息的现成手段。我们开发的技术使我们能够定量测量肺密度（空气含量的直接测量）、肺血流量和特定肺密度的空间分布。 通风。这些技术共同使我们能够定量绘制通气-灌注比 （V？A/Q？），它唯一地决定了肺气体交换，其空间分辨率接近人肺功能气体交换单元的尺度。该生物工程研究合作伙伴关系 (BRP) 前五年的总体目标是使这些研究技术能够转化为更广泛的研究界，以便它们可以用作研究和临床试验中的生物标志物，并以临床适用性为未来目标。为此，这些技术需要： a) 加强其生理解释，为解释其产生的结果提供严格的基础； b) 进一步发展为高效且易于使用的临床研究技术； c) 进行验证研究以证明其对临床研究的适用性。为此，我们提出了一系列协调一致的研究，这些研究将：1）使用高度解剖学真实的计算机模型将所有成像模式的生理学解释置于合理的基础上； 2) 通过与临床前大型动物模型中注射和吸入微球测量结果进行比较，验证灌注、通气和 V A/Q 的成像； 3) 在正常肺和患病肺中，通过多重惰性气体消除技术的金标准非成像方法获得的 VA/Q 定量测量值，交叉验证人体中 VA/Q 的成像； 4) 优化当前的 MR 方法，并通过改进的技术扩展功能性肺部成像的范围。该 BRP 的完成将带来一套经过验证的定量功能 MR 肺部成像方法，可用于商用扫描仪来测量密度、灌注、通气和通气-灌注比。