UMass Mouse Metabolic Phenotyping Center - Animal Core

麻省大学小鼠代谢表型中心 - 动物核心

• 批准号: 9174712
• 负责人: Jerald Silverman
• 金额: $ 8.38万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9174712
• 关键词: Accelerometer; Animals; Beta Cell; Cell Transplantation; Communities; Consult; Cross Infection; Diagnostic; Diet; Ensure; Exogenous Factors; Fasting; Goals; Health; Health Status; Healthcare; High Fat Diet; House mice; Housing; Human; Human Resources; Immunodeficient Mouse; Infectious Agent; Medicine; Mus; Operative Surgical Procedures; Oral; Phenotype; Preventive Medicine; Procedures; Process; Quarantine; Research; Role; Serologic tests; Services; Site; Source; Stem cells; Supervision; Techniques; Testing; Therapeutic; Training; Transgenic Model; Transplantation; abstracting; animal care; animal facility; cohort; feeding; humanized mouse; in vivo; instrument; islet; islet stem cells; medical schools; metabolic phenotype; microorganism; operation; programs; screening; stressor

Project Summary - Abstract Precise phenotyping depends significantly on the quality of animal subjects. Stable housing and husbandry minimize the influence of exogenous factors that could distort phenotyping results. Additionally, mice submitted to the UMass MMPC share space with cohorts from microbiologically diverse sources. They, as well as mice housed in resident colonies, must be protected against potential cross-infection by adventitious agents. The Animal Core operates under the supervision of Dr. Jerald Silverman as the Core Director, who oversees the animal care facility of UMass Medical School. The Humanized Mouse Cell Transplantation and Assessment sub-Core is directed by Dr. Dale Greiner who will offer the humanized mice and elegant techniques to assess in vivo function of transplanted human islets and stem cell-derived β-cells in immunodeficient mice. The sub-Core will perform standardized assessment procedures that will provide quantifiable metrics for the transplanted human islets or stem cell-derived β-cells. The Animal Core provides facilities and services relevant to these priorities under the following specific aims: (1) to provide stable, biocontainment housing, husbandry and health care for mice (2) to provide a dedicated animal facility for housing (AS2-1043 and 1042) and on-site phenotyping procedures (AS2-1043A) with additional phenotyping instruments, (3) to assess the microbiological profile of each cohort and provides the Center Director with interpretation and advice regarding the results, and (4) to provide to the users of the phenotyping service, at the discretion of the Center Director, results and advice on the health status of submitted mice. The goal of the Animal Core is to support the operation of UMass MMPC with issues pertinent to animal care and quality of phenotyping mice.

项目摘要-摘要