ANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASE

 描述(由申请人提供)：这是一份竞争性续签申请，旨在继续支持德克萨斯大学西南医学中心(UTSW)儿科儿童健康研究职业发展奖(CHRCDA)计划。UTSW及其儿科系处于理想的位置，可以提供支持性环境、敬业的导师、关键的核心资源，最重要的是，成为该奖项的最终受益者的优秀临床医生-科学家的流动。我们的目标是激励并使这些年轻的科学家成为下一代富有想象力、独立和成熟的调查人员，专注于对婴儿和儿童一生中重要的疾病的研究。我们认为，我们的CHRCDA项目是唯一有资格实现这一目标的项目，原因如下：1)我们组建了一支培训教师队伍，提供巨大的学科多样性，跨越9个大学系和4个自治中心，同时统一专注于我们CHRCDA的发展主题；2)我们确定的生物过程不仅对儿科至关重要，而且还利用现有的优势和 德克萨斯大学西南分校基础科学和临床科室之间建立了良好的研究和培训合作；3)认识到在年轻医生中促进研究职业生涯的必要性从未像现在这样重要，我们系致力于在早期阶段确定最佳候选人，并为他们提供成功发展为独立儿科医生所需的鼓励和资源--热爱发现的科学家；4)尽管课程时间很短，但我们的计划已经证明了它有能力实现NIH为CHRCDA建立的目标，这一点从我们所有三名毕业学者在参加计划期间或毕业后一年内成功获得K08或同等的联邦支持就是明证。德克萨斯大学西南分校的CHRCDA计划一次最多支持四名学者，每个人的任期为两年(可能延长到三年)。在参与该计划期间，学者们将遵循个性化的研究指导计划，并将在导师的监督下将至少80%的精力投入到严格的研究计划中。每位学者的经验将继续强调确定引人注目的与临床相关的科学问题，保持项目重点，创造性的实验设计，最先进的技术，以及深思熟虑的早期职业指导。

 DESCRIPTION (provided by applicant): This is a competitive renewal application for continued support of the Child Health Research Career Development Award (CHRCDA) Program in the Department of Pediatrics at the University of Texas Southwestern Medical Center (UTSW). UTSW and its Department of Pediatrics are ideally positioned to provide the supportive environment, the dedicated mentors, the critical core resources, and, most importantly, the stream of talented clinician-scientists that become the ultimate beneficiaries of this award. Our goal is to motivate and enable these young scientists to become the next generation of imaginative, independent, and sophisticated investigators focused on the diseases of major importance to infants and children throughout their lifetimes. We believe that our CHRCDA Program is uniquely qualified to accomplish this goal for the following reasons: 1) we have assembled a training faculty that offers enormous subject diversity, spanning nine university departments and four autonomous centers, and is at the same time uniformly focused on the developmental theme of our CHRCDA; 2) the biologic processes that we have identified for study are not only critically important to pediatrics, but also leverage existing strengths and well-established research and training collaborations between basic science and clinical departments at UT Southwestern; 3) recognizing that there has been no other time when the need to promote research careers among young physicians has been more crucial, our Department is committed to identifying the best candidates from an early stage and providing them with the encouragement and resources requisite to successful development into independent pediatric physician-scientists with a passion for discovery; and 4) despite its short course of four years, our Program has demonstrated its ability to achieve the goals established by NIH for the CHRCDA as evidenced by the success of all three of our graduating scholars in obtaining K08 or equivalent federal support either during their participation in the Program or within one year of their graduation. The CHRCDA Program at UT Southwestern will support a maximum of four Scholars at a time, each receiving an appointment of two years (which may be extended to three). During their participation in the Program, the Scholars will follow a personalized plan for research instruction and will dedicate a minimum of 80% of their effort to a rigorous research plan under the supervision of a mentor. Each Scholar's experience will continue to emphasize the identification of compelling clinically-relevant scientific questions, maintenance of project focus, creative experimental design, state-of-the-art technology, and thoughtful early career guidance.