Antecedants Sequelae of Childhood Onset Disease

描述(由申请人提供)：这是一项新的提议，在德克萨斯大学西南医学中心(UTSW)设立一个儿童健康研究职业发展奖励计划，由儿科系主持，乔治·李斯特担任PI，菲利普·绍尔担任TD。UTSW和儿科系处于理想的地位，可以提供环境、敬业的导师、核心资源和有才华的临床医生-科学家流，他们将从这个奖项中获得不可估量的好处，并反过来成为下一代富有想象力的、独立的和成熟的研究人员，专注于对婴儿和儿童一生中重要的疾病。我们的目标是：将未来最有才华和最忠诚的儿科教师与校园内最好的科学指导和研究环境相匹配，从而为我们的学者提供成为多产和有创造力的科学家所需的工具和必要的基础；提供时间、结构、财务支持和最小的分心，以帮助鼓励他们追求新颖和富有想象力的策略，以解决最重要和最令人困惑的医疗问题；并培养这些学者，以培养和加强对持久职业生涯至关重要的兴奋、坚韧和同行互动。我们组织了这个职业发展计划，主题是儿童期疾病的前驱和后遗症，包括7个主题。这些主题中正在研究的生物和病理生理学过程对儿科至关重要，它们利用了UTSW现有的优势，以及儿科导师和我们校园基础科学系之间建立的非常良好的研究和培训合作，它们是该校院长咨询委员会制定的最新战略计划中最优先考虑的领域。 与公共卫生相关：这是一项新的提议，旨在培养优秀的年轻儿科医生-科学家，使他们专注于儿童疾病的前驱和后遗症。成年期的许多疾病都起源于发育过程，包括1)早期有症状并持续终生(如自闭症)；2)完全依赖于侮辱的时机并具有潜在破坏性的长期后果(如支气管-肺发育不良)；3)儿童及其后的高发病率和死亡率(如癌症、2型糖尿病)；以及4)在婴儿期和儿童期出现的病因，当时这些疾病是亚临床的，并在以后的生活中导致巨大的发病率和死亡率(如脂肪肝、高血压、动脉粥样硬化)。

DESCRIPTION (provided by applicant): This is a new proposal to establish a Child Health Research Career Development Award Program at the University of Texas Southwestern Medical Center (UTSW) under the aegis of the Department of Pediatrics with George Lister as PI and Philip Shaul as TD. UTSW and the Dept of Pediatrics are ideally positioned to provide the environment, the dedicated mentors, the core resources, and the stream of talented clinician-scientists that would benefit immeasurably from this award and would, in turn, become the next generation of imaginative, independent, and sophisticated investigators focused on the diseases of major importance to infants and children throughout their lifetimes. Our aims are: to identify and match the most talented and committed future pediatric faculty with the very best scientific mentorship and research environments on this campus, and thereby provide our Scholars with the requisite tools and needed foundation to become productive and creative scientists; to provide time, structure, financial support and minimal distraction to help encourage them to pursue novel and imaginative strategies to address the most important and perplexing medical problems; and to nurture these Scholars in order to foster and reinforce the excitement, fortitude, and peer interactions that are essential for a durable career. We have organized this Career Development Program with an overarching theme, Antecedents & Sequelae of Childhood Onset Diseases, with 7 thematic components. The biologic and pathophysiologic processes under study within these themes are of paramount importance to pediatrics, they capitalize on existing strengths at UTSW and very well established research and training collaborations existing between mentors in the Department of Pediatrics and the basic science faculty on our campus, and they represent areas of the highest priority in the newest strategic plan forged by the Dean's Advisory Committee at the school. PUBLIC HEALTH RELEVANCE: This is new proposal is intended to train outstanding young pediatric physician-scientists to focus on the antecedents and sequelae of childhood diseases. Many diseases of adulthood have their origin in developmental processes and these include conditions that 1) have expression early and continue throughout life (e.g. autism); 2) have etiologies entirely dependent on the timing of an insult and have potentially devastating long term consequences (e.g. broncho-pulmonary dysplasia); 3) are characterized by high morbidity and mortality both during childhood and thereafter (e.g. cancer, type 2 diabetes); and 4) have etiologies that arise during infancy and childhood at which time they are subclinical, and result in great morbidity and mortality later in life (e.g. fatty liver disease, hypertension, atherosclerosis).