ARX- A hub gene for a common biological pathway in schizophrenia

ARX-精神分裂症常见生物途径的枢纽基因

• 批准号: nhmrc : 2000893
• 金额: $ 70.8万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/arx-a-hub-pathway-schizophrenia/1779663
• 关键词: ARX; hub; gene; common; biological

Schizophrenia is a severe psychiatric disorder with no cure. I have identified that some people with schizophrenia show variations to a gene called ARX. This project will use preclinical mouse models to explore how variations to the Arx gene affect brain molecules, networks of cells and behavioural outcomes. This biological pathway will provide the framework for the identification of new molecules to target therapeutically to modify the biological course of schizophrenia and improve outcomes.

精神分裂症是一种无法治愈的严重精神疾病。我已经发现，一些精神分裂症患者显示出一种名为ARX的基因的变异。该项目将使用临床前小鼠模型来探索Arx基因的变异如何影响大脑分子，细胞网络和行为结果。这种生物学途径将为识别新的分子提供框架，以治疗为目标，以改变精神分裂症的生物学过程并改善结果。