CODA: COvid and Diabetes Assessment
CODA:新冠肺炎和糖尿病评估
基本信息
- 批准号:10755899
- 负责人:
- 金额:$ 599.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-21 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAdultAmericanAntibodiesAreaBeta CellBiological MarkersBiological ProcessBlood VesselsCDC42 geneCOVID-19COVID-19 diagnosisCOVID-19 impactCOVID-19 pandemicCOVID-19 patientCOVID-19 surveillanceCOVID-19 testCOVID-19 treatmentCell physiologyCessation of lifeChildChildhoodChildhood diabetesClinicalClinical ResearchConsentDataDeteriorationDevelopmentDiabetes MellitusDiagnosisElectronic Health RecordEnvironmental Risk FactorEpidemiologyFamilyFibrosisFundingFutureGenomicsGlucose tolerance testHealthHealth Services ResearchHealth systemIndividualInfectionInflammationInformaticsInfrastructureInsulin ResistanceInsulin-Dependent Diabetes MellitusInternetInterventionIntervention StudiesLinkLong COVIDMetabolicMulticenter TrialsNon-Insulin-Dependent Diabetes MellitusNucleocapsidObesityObservational StudyOutcomeOutpatientsParticipantPatientsPhysiologicalPhysiologyPopulationPost-Acute Sequelae of SARS-CoV-2 InfectionProcessPublic HealthRecordsRegistriesResearchResourcesRiskRoleSARS-CoV-2 exposureSARS-CoV-2 infectionSARS-CoV-2 negativeSerology testSiteStandardizationStructureStudy SubjectSurveysTelephoneTestingThrombophiliaTimeUnited States National Institutes of HealthWorkcohortcommunity engagementcoronavirus diseasedata hubdrug repurposingelectronic health dataepidemiology studyexperienceglycemic controlimprovedmembermetabolomicspandemic diseasepatient orientedpatient portalpatient registrypatient subsetsrecruitsocialtype 2 diabetes in childrentype I and type II diabetes
项目摘要
Project Summary
Several studies have found that infection with SARS-CoV-2 and COVID-19 diagnosis are associated with the
development and progression of both Type 1 (T1D) and Type 2 Diabetes (T2D), possibly through infection of
beta cells, increased insulin resistance, increased inflammation and fibrosis, and other biological processes.
The proposed study will take advantage of robust existing infrastructure to rapidly identify, recruit, and retain
diverse cohorts of English and Spanish speaking pediatric and adult patients with recently diagnosed T1D or
T2D. The study will include 1600 study participants diagnosed with diabetes in the last 3 months, who have
had a known COVID-19 infection in the past 90 days and those with recent diagnosis of diabetes and no
known COVID-19 infection in the past year. The study will leverage PCORnet, a unique national network of
over 60 health systems with electronic health record (EHR) data on over 80 million patients and a track record
for successful study recruitment. We will query EHR records to swiftly identify potential study subjects with
recent diagnosis of diabetes and contact them via patient portals, telephone, face-to-face encounters, and
other approaches. We will also leverage the T1D Exchange (T1DX), a national network of 54 diabetes centers
and an online patient registry of 17,000 individuals with T1D. Consented participants will partake in regular
web/mobile or telephone surveys leveraging a previously developed REDCap/Twilio platform. Participants will
also come to sites for regular serological testing, and a subsample will participate in more robust testing of
glucose tolerance, biomarkers, and vascular function. This data will be supplemented by longitudinal EHR data
from participating sites and across PCORnet. Participants will be followed for 2 years. Aim 1 will examine if
patients with recent T2D who have recent COVID-19 are more likely to have worse glycemic control, increased
inflammation and increased insulin resistance than patients without recent COVID-19. Aim 2 will examine if
patients with recent T1D who have recent COVID-19 are more likely to have worse glycemic control, increased
inflammation and more rapid reduction in beta cell function than patients without recent COVID-19. Aim 3 will
evaluate a subset of patients with diabetes to examine if COVID-19 is associated with worse vascular function,
increased inflammation and hypercoagulability. Aim 4 will explore the role of genomic/social/environmental
factors on inflammation and metabolic function. Aim 5 will leverage EHR data to explore the role of COVID-19
and COVID-19 treatments on diabetes development and diabetes-related outcomes across the pandemic. The
study will be led by a team with significant experience related to COVID-19, post-acute sequelae of COVID-19
(PASC), obesity and diabetes in children and adults, epidemiological research, informatics, health services
research, genomics, metabolomics, physiology, patient and family engagement and other areas. The proposed
work will provide a deeper understanding of the relationship between COVID-19 and diabetes, that can support
future interventions and public health approaches to improve health.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Jason Perry Block', 18)}}的其他基金
Medications and Weight Gain in PCORnet: The MedWeight Study
PCORnet 中的药物和体重增加:MedWeight 研究
- 批准号:
10348172 - 财政年份:2020
- 资助金额:
$ 599.96万 - 项目类别:
Medications and Weight Gain in PCORnet: The MedWeight Study
PCORnet 中的药物和体重增加:MedWeight 研究
- 批准号:
10560490 - 财政年份:2020
- 资助金额:
$ 599.96万 - 项目类别:
Medications and Weight Gain in PCORnet: The MedWeight Study
PCORnet 中的药物和体重增加:MedWeight 研究
- 批准号:
9885751 - 财政年份:2020
- 资助金额:
$ 599.96万 - 项目类别:
New Insights into the Federal Calorie Labeling Law
对联邦卡路里标签法的新见解
- 批准号:
10372096 - 财政年份:2018
- 资助金额:
$ 599.96万 - 项目类别:
Label to Table: New Insights into Supermarket Food Labeling
从标签到餐桌:超市食品标签的新见解
- 批准号:
10584973 - 财政年份:2018
- 资助金额:
$ 599.96万 - 项目类别:
Workplace Wellness Initiatives to Combat Obesity
对抗肥胖的工作场所健康举措
- 批准号:
8721478 - 财政年份:2013
- 资助金额:
$ 599.96万 - 项目类别:
Workplace Wellness Initiatives to Combat Obesity
对抗肥胖的工作场所健康举措
- 批准号:
8857151 - 财政年份:2013
- 资助金额:
$ 599.96万 - 项目类别:
Workplace Wellness Initiatives to Combat Obesity
对抗肥胖的工作场所健康举措
- 批准号:
8509142 - 财政年份:2013
- 资助金额:
$ 599.96万 - 项目类别:
Workplace Wellness Initiatives to Combat Obesity
对抗肥胖的工作场所健康举措
- 批准号:
9315197 - 财政年份:2013
- 资助金额:
$ 599.96万 - 项目类别:
Workplace Wellness Initiatives to Combat Obesity
对抗肥胖的工作场所健康举措
- 批准号:
9081666 - 财政年份:2013
- 资助金额:
$ 599.96万 - 项目类别:
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