Drug Combinations to Enhance Sensitivity and Circumvent Resistance

项目摘要/摘要--行政核心 行政核心将提供领导、科学监督、治理和行政支持，以 我们规避耐药性的药物组合-耐药性和敏感性中心(D2CR-DRSc) 确保有效的运营、沟通、内部和外部协作、合规和严谨 对D2CR-DRSc项目进行科学评估。联合PD/联系Pi Jeffrey Tyner和Co-PD/Pi Brian Druker Will 担任行政核心的共同领导人，并将由一名科学业务负责人提供支助， Cristina Tognon；协作经理Pierrette Lo；以及研究和财务管理员Sarah 鲍登。行政核心的具体目标是：1)提供科学和行政 对D2CR-DRSC的领导、治理和支持，以确保有效整合所有项目， 评估中心进展、共享标本和数据、内部沟通和运作 性能，以及2)提供科学和管理领导，以优化D2CR-DRSC 与抗药性和敏感度网络的沟通和合作，以确保富有成效 参与跨DRSC、NCI活动和研究界。为了实现这些目标， 行政核心将建立和实施D2CR-DRSC治理，包括建立内部 咨询小组和外部咨询委员会，以帮助评估中心在实现其目标和 里程碑；制定和遵循政策，以确保及时发布和共享标本和数据；定期计划 战略互动和会议；制定沟通计划；确保预算监督和遵守； 管理知识产权问题；完成年度进度报告；促进沟通、协作 以及与NCI、DRSC指导委员会和 并履行支持D2CR-DRSC及其成功实施所需的所有其他行政职责 参与抗药性和敏感性网络。

PROJECT SUMMARY/ABSTRACT – Administrative Core The Administrative Core will provide leadership, scientific oversight, governance, and administrative support to our Drug Combinations to Circumvent Resistance-Drug Resistance and Sensitivity Center (D2CR-DRSC) to ensure effective operations, communication, internal and external collaborations, compliance and rigorous scientific evaluation of D2CR-DRSC projects. Co-PD/Contact PI Jeffrey Tyner and Co-PD/PI Brian Druker will serve as Co-Leaders of the Administrative Core and will be supported by a Scientific Operations Leader, Cristina Tognon; a Collaborations Manager, Pierrette Lo; and a Research and Finance Administrator, Sarah Bowden. The Specific Aims of the Administrative Core are to: 1) provide scientific and administrative leadership, governance, and support to the D2CR-DRSC to ensure effective integration of all projects, evaluation of center progress, sharing of specimens and data, and internal communication and operational performance, and 2) provide scientific and administrative leadership to optimize the D2CR-DRSC’s communication and collaborations with the Drug Resistance and Sensitivity Network to ensure productive participation in cross-DRSC, NCI activities and the research community. To achieve these aims, the Administrative Core will establish and implement D2CR-DRSC governance, including establishing an Internal Advisory Group and an External Advisory Board to help evaluate the Center’s progress toward its aims and milestones; develop and follow policy to ensure timely release and sharing of specimens and data; plan regular strategic interactions and meetings; develop communications plans; ensure budget oversight and compliance; manage intellectual property issues; complete annual progress reports; facilitate communication, collaboration and data and resource sharing with the NCI, the DRSC Steering Committee, and the four other DRSCs in the Network; and perform all other administrative duties required to support the D2CR-DRSC and its successful participation in the Drug Resistance and Sensitivity Network.