Core A: Administrative Core

项目摘要/摘要：行政核心 我们专注于白血病的Artnet研究中心的总体目标是了解 耐药性受时间、外在和内在因素的支配，以确定新的治疗策略 领先于急性髓系白血病(AML)患者的肿瘤进化和适应。要做到这一点 Goal，我们组建了一支出色的白血病研究团队，将基础/机械和 从事临床前/转化性研究，共同研究急性髓细胞白血病生物学超过15年。这个 管理核心将提供领导、科学监督、治理、集成和管理 为Artnet研究中心提供支持，以确保内部和外部的有效运营和沟通 对Artnet财团资助的项目进行协作、合规和严格的科学评估。这个 行政核心联合领导Jeffrey Tyner博士(联系M-PD/PI)和Cristina Tognon博士一直在工作 在一起工作了近十年，他们两人在这段时间里都在行政部门密切合作 核心生物统计学和生物信息学领导和整体M-PD/PI，Shannon McWeeney博士。他们将会是 由经验丰富的研究和财务管理人莎拉·鲍登支持。的具体目标 行政核心是：1)通过提供治理和 科学整合中心，制定和实施人员配备计划；2)创造环境 这促进了项目和核心之间的重点和协同关系；3)提供Artnet 研究中心合规监督和评估科学进步；以及4)使快速传播 数据和资源。为了实现这些目标，行政核心将建立和实施ARTnet 研究中心治理，包括建立科学咨询委员会(SAB)以帮助评估 中心在实现目标和里程碑方面的进展；计划定期的战略互动和会议；制定 沟通计划；确保预算监督和合规；管理知识产权问题；完成 年度进度报告；促进定期和及时的沟通；促进中心内的协作 以及与外部协作；并履行支持ARTnet所需的所有其他管理职责 研究中心及其成功参与获得性抵抗治疗网络。

PROJECT SUMMARY/ABSTRACT: Administrative Core The overall goal of our leukemia focused ARTNet Research Center is to understand how the architecture of resistance is governed by temporal extrinsic and intrinsic factors in order to identify novel therapeutic strategies to stay ahead of tumor evolution and adaptation in patients with Acute Myeloid Leukemia (AML). To achieve this goal, we have assembled an exceptional team of leukemia researchers that bridge basic/mechanistic and preclinical/translational research who have worked extensively together for 15+ years studying AML biology. The Administrative Core will provide leadership, scientific oversight, governance, integration, and administrative support to the ARTNet Research Center to ensure effective operations, communication, internal and external collaborations, compliance, and rigorous scientific evaluation of ARTNet Consortium funded projects. The Administrative Core co-Leads, Dr. Jeffrey Tyner (Contact M-PD/PI) and Dr. Cristina Tognon, have been working together for close to a decade, and they have also both worked closely for this entire time with Administrative Core Biostatistics and Bioinformatics Lead and Overall M-PD/PI, Dr. Shannon McWeeney. They will be supported by a highly experienced Research and Finance Administrator, Sarah Bowden. The specific aims of the Administrative Core are to: 1) Provide overall administrative management by providing governance and scientific integration of the Center and developing and implementing a staffing plan; 2) Create an environment that fosters a focused and synergistic relationship between the Projects and the Cores; 3) Provide ARTNet Research Center compliance oversight and evaluate scientific progress; and 4) Enable rapid dissemination of data and resources. To achieve these aims, the Administrative Core will establish and implement ARTNet Research Center governance, including establishing a Scientific Advisory Board (SAB) to help evaluate the Center’s progress toward its aims and milestones; plan regular strategic interactions and meetings; develop communication plans; ensure budget oversight and compliance; manage intellectual property issues; complete annual progress reports; facilitate regular and timely communication; facilitate collaboration within the Center and with external collaborations; and perform all other administrative duties required to support the ARTNet Research Center and its successful participation in the Acquired Resistance to Therapy Network.