Core A: Administrative Core

项目总结/摘要：行政核心 我们关注白血病的ARTNet研究中心的总体目标是了解 耐药受时间外在和内在因素的控制，以确定新的治疗策略 在急性髓系白血病（AML）患者中保持领先的肿瘤演变和适应。实现这一 为了实现这一目标，我们组建了一个由白血病研究人员组成的特殊团队， 临床前/转化研究团队，他们在AML生物学研究方面共同工作了15年以上。的 行政核心将提供领导、科学监督、治理、整合和行政管理。 支持ARTNet研究中心，以确保有效的运营，沟通，内部和外部 对ARTNet联盟资助的项目进行合作、合规性和严格的科学评估。的 行政核心共同负责人Jeffrey泰纳博士（联系M-PD/PI）和Cristina Tognon博士一直在 在一起近十年，他们也都密切合作，这整个时间与行政 核心生物统计学和生物信息学负责人和总体M-PD/PI，Shannon McWeeney博士。他们将 由经验丰富的研究和财务管理员Sarah Bowden提供支持。的具体目标 行政核心是：1）通过提供治理和 科学整合中心，制定和实施人员配备计划; 2）创造环境 促进项目和核心之间的重点和协同关系; 3）提供ARTNet 研究中心的合规监督和评估科学进展;以及4）能够快速传播 数据和资源。为实现这些目标，行政核心将建立和实施非洲贸易研究和培训网， 研究中心治理，包括建立科学咨询委员会（SAB），以帮助评估 中心在实现其目标和里程碑方面的进展;计划定期的战略互动和会议;制定 沟通计划;确保预算监督和合规;管理知识产权问题;完成 年度进展报告;促进定期和及时的沟通;促进中心内的合作 并与外部合作;并履行支持非洲热带农业研究网络所需的所有其他行政职责 研究中心及其成功参与获得性耐药性治疗网络。

PROJECT SUMMARY/ABSTRACT: Administrative Core The overall goal of our leukemia focused ARTNet Research Center is to understand how the architecture of resistance is governed by temporal extrinsic and intrinsic factors in order to identify novel therapeutic strategies to stay ahead of tumor evolution and adaptation in patients with Acute Myeloid Leukemia (AML). To achieve this goal, we have assembled an exceptional team of leukemia researchers that bridge basic/mechanistic and preclinical/translational research who have worked extensively together for 15+ years studying AML biology. The Administrative Core will provide leadership, scientific oversight, governance, integration, and administrative support to the ARTNet Research Center to ensure effective operations, communication, internal and external collaborations, compliance, and rigorous scientific evaluation of ARTNet Consortium funded projects. The Administrative Core co-Leads, Dr. Jeffrey Tyner (Contact M-PD/PI) and Dr. Cristina Tognon, have been working together for close to a decade, and they have also both worked closely for this entire time with Administrative Core Biostatistics and Bioinformatics Lead and Overall M-PD/PI, Dr. Shannon McWeeney. They will be supported by a highly experienced Research and Finance Administrator, Sarah Bowden. The specific aims of the Administrative Core are to: 1) Provide overall administrative management by providing governance and scientific integration of the Center and developing and implementing a staffing plan; 2) Create an environment that fosters a focused and synergistic relationship between the Projects and the Cores; 3) Provide ARTNet Research Center compliance oversight and evaluate scientific progress; and 4) Enable rapid dissemination of data and resources. To achieve these aims, the Administrative Core will establish and implement ARTNet Research Center governance, including establishing a Scientific Advisory Board (SAB) to help evaluate the Center’s progress toward its aims and milestones; plan regular strategic interactions and meetings; develop communication plans; ensure budget oversight and compliance; manage intellectual property issues; complete annual progress reports; facilitate regular and timely communication; facilitate collaboration within the Center and with external collaborations; and perform all other administrative duties required to support the ARTNet Research Center and its successful participation in the Acquired Resistance to Therapy Network.