Core A: Administrative Core

核心A：行政核心

• 批准号: 10517758
• 负责人: Jeffrey Wallace Tyner
• 金额: $ 7.01万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517758
• 关键词: Acute Myelocytic Leukemia; Administrator; Agreement; Architecture; Bioinformatics; Biology; Biostatistics Core; Budgets; Clinical; Collaborations; Communication; Communities; Complex; Congresses; Data; Ensure; Environment; Evaluation; Evolution; Fostering; Funding; Goals; Grant; Heme; Individual; Intellectual Property; Intrinsic factor; Laboratories; Lead; Leadership; National Cancer Institute; Office of Administrative Management; Outcome; Patients; Performance; Preparation; Progress Reports; Recommendation; Research; Research Personnel; Resistance; Scientific Evaluation; Scientist; Specimen; System; Technology; Time; TimeLine; Translational Research; Travel; Work; acquired drug resistance; data dissemination; data resource; data sharing; experience; innovation; leukemia; meetings; novel therapeutic intervention; operation; pre-clinical; programs; therapy resistant; tumor

PROJECT SUMMARY/ABSTRACT: Administrative Core The overall goal of our leukemia focused ARTNet Research Center is to understand how the architecture of resistance is governed by temporal extrinsic and intrinsic factors in order to identify novel therapeutic strategies to stay ahead of tumor evolution and adaptation in patients with Acute Myeloid Leukemia (AML). To achieve this goal, we have assembled an exceptional team of leukemia researchers that bridge basic/mechanistic and preclinical/translational research who have worked extensively together for 15+ years studying AML biology. The Administrative Core will provide leadership, scientific oversight, governance, integration, and administrative support to the ARTNet Research Center to ensure effective operations, communication, internal and external collaborations, compliance, and rigorous scientific evaluation of ARTNet Consortium funded projects. The Administrative Core co-Leads, Dr. Jeffrey Tyner (Contact M-PD/PI) and Dr. Cristina Tognon, have been working together for close to a decade, and they have also both worked closely for this entire time with Administrative Core Biostatistics and Bioinformatics Lead and Overall M-PD/PI, Dr. Shannon McWeeney. They will be supported by a highly experienced Research and Finance Administrator, Sarah Bowden. The specific aims of the Administrative Core are to: 1) Provide overall administrative management by providing governance and scientific integration of the Center and developing and implementing a staffing plan; 2) Create an environment that fosters a focused and synergistic relationship between the Projects and the Cores; 3) Provide ARTNet Research Center compliance oversight and evaluate scientific progress; and 4) Enable rapid dissemination of data and resources. To achieve these aims, the Administrative Core will establish and implement ARTNet Research Center governance, including establishing a Scientific Advisory Board (SAB) to help evaluate the Center’s progress toward its aims and milestones; plan regular strategic interactions and meetings; develop communication plans; ensure budget oversight and compliance; manage intellectual property issues; complete annual progress reports; facilitate regular and timely communication; facilitate collaboration within the Center and with external collaborations; and perform all other administrative duties required to support the ARTNet Research Center and its successful participation in the Acquired Resistance to Therapy Network.

项目摘要/摘要：行政核心 我们以白血病为中心的Artnet研究中心的总体目标是了解 阻力受临时外部和内在因素的控制，以识别新型的治疗策略 急性髓样白血病（AML）的患者保持领先于肿瘤的进化和适应。实现这一目标 目标，我们组建了一个杰出的白血病研究人员团队 临床前/转化研究，他们在研究AML生物学研究15年以上，共同努力。这 行政核心将提供领导，科学监督，治理，整合和行政 支持Artnet研究中心，以确保有效的操作，沟通，内部和外部 ARTNET财团资助的项目的合作，合规性和严格的科学评估。这 行政核心共同领导者Jeffrey Tyner博士（联系M-PD/PI）和Cristina Tognon博士一直在工作 近十年一起在一起，他们在整个过程中都密切合作 核心生物统计学和生物信息学的铅和整体M-PD/PI，Shannon McWeeney博士。他们会的 在经验丰富的研究和财务管理员莎拉·鲍登（Sarah Bowden）的支持下。具体目的 行政核心是：1）通过提供治理和 中心的科学整合，制定和实施人员配备计划； 2）创建一个环境 这建立了项目与核心之间的重点和协同关系。 3）提供artnet 研究中心的合规性监督并评估科学进步； 4）能够快速传播 数据和资源。为了实现这些目标，行政核心将建立和实施ARTNET 研究中心的治理，包括建立科学顾问委员会（SAB），以帮助评估 中心朝着其目标和里程碑的进步；计划定期的战略互动和会议；发展 沟通计划；确保预算监督和合规；管理知识产权问题；完全的 年度进度报告；促进常规和及时的沟通；促进中心内的合作 以及外部协作；并履行支持Artnet所需的所有其他行政职责 研究中心及其成功参与了对治疗网络的抵抗力。