Non-pharmacological improvement of sleep structure in older people

非药物改善老年人睡眠结构

• 批准号: 9346710
• 负责人: DMITRY GERASHCHENKO
• 金额: $ 34.9万
• 依托单位: MOBILE SLEEP TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9346710
• 关键词: Accidents; Acoustic Stimulation; Address; Adult; Age; Aging; Algorithms; Apple; Attention; Computer software; Data; Decision Making; Detection; Devices; Elderly; Electroencephalogram; Ensure; Frequencies; Health; Health Care Costs; Heart; Home environment; Human; Impairment; Individual; Laboratories; Laboratory Study; Legal patent; Letters; Licensing; Measurement; Measures; Memory; Neuropsychological Tests; Patients; Pattern; Physiological; Polysomnography; Population; Procedures; Production; Productivity; REM Sleep; Research; Research Personnel; Safety; Sleep; Sleep Fragmentations; Sleep Stages; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; Somatotropin; Structure; System; Technology; Testing; Time; Validation; Wrist; actigraphy; age related; base; cognitive ability; cognitive performance; executive function; fitbit; healthy volunteer; heart rate variability; improved; interest; memory consolidation; middle age; non rapid eye movement; novel; optical sensor; procedural memory; response; restoration; sleep onset; volunteer

ABSTRACT Poor sleep and memory problems are common in older adults and have considerable consequences including decreased productivity, declines in cognitive abilities, increased rate of accidents and traffic fatalities, and increased health care costs. These sleep and memory problems often occur in midlife and in older adults, when aging is associated with insomnia, fragmentation of sleep, and impairment of attention. Aging also impacts sleep stages and sleep depth, with marked changes in non-rapid eye movement (NREM) sleep, an increase in lighter NREM sleep stages (N1 or N2 stage of sleep) and a decrease in deep or “slow wave” sleep (N3 stage of sleep). Because deep sleep has been associated with the recuperative function of sleep, memory consolidation, and growth hormone release, age-related reduction in deep sleep has a negative impact on physiologic restoration, memory, and overall health. The overall objective of this proposed research is to develop a non-pharmacological means to address sleep deficiencies and well- being in older midlife adults. Several laboratory studies recently demonstrated that precisely-delivered, specific auditory stimulation in adults results in an enhancement of slow waves on the electroencephalogram (EEG) and improvement in memory. Since older adults have a significant reduction in deep sleep, increasing slow wave production by precisely-delivered auditory stimulation could be particularly useful for this population. To date, the use of auditory stimulation to improve sleep has been limited to adult volunteers in laboratory settings. Our objective is to validate, modify, and improve the application of specific auditory stimulation to increase deep sleep in older individuals, and to develop a system that can deliver slow wave sleep enhancement in the home. Both healthy people and patients with disturbances of sleep and memory could benefit from using this system. It will be especially useful in older people. Our new system will be inexpensive, simple and easy to use.

摘要 睡眠不佳和记忆力问题在老年人中很常见，并会造成相当大的后果 包括生产力下降、认知能力下降、事故率和交通事故发生率上升 死亡人数和增加的医疗费用。这些睡眠和记忆问题通常发生在中年和 老年人，当衰老与失眠、睡眠支离破碎和注意力障碍有关时。 衰老还会影响睡眠阶段和睡眠深度，非快速眼动会发生显著变化 (NREM)睡眠，较浅的NREM睡眠阶段(N1或N2期)增加，深度睡眠减少 或“慢波”睡眠(N3期睡眠)。因为深度睡眠与休养生息有关 深度睡眠的睡眠功能、记忆巩固和生长激素释放，与年龄相关的减少 对生理恢复、记忆和整体健康有负面影响。这样做的总体目标是 拟议的研究是开发一种非药物方法来解决睡眠不足和良好的 处于中年高龄人群中。最近的几项实验室研究表明，精确交付， 成人的特定听觉刺激导致脑电慢波的增强 脑电(EEG)和记忆力的改善。因为老年人有一个显著的减少 在深度睡眠中，通过精确传递的听觉刺激来增加慢波产生可能是 对这群人来说尤其有用。到目前为止，使用听觉刺激来改善睡眠一直是 仅限于实验室环境中的成年志愿者。我们的目标是验证、修改和改进 应用特定的听觉刺激来增加老年人的深度睡眠，并发展一种 可在家中提供慢波睡眠增强功能的系统。无论是健康人还是患有糖尿病的患者 睡眠和记忆障碍可以从使用这个系统中受益。它将在较老的版本中特别有用 人民。我们的新系统将是廉价、简单和易于使用的。