Non-pharmacological improvement of sleep structure in older people

非药物改善老年人睡眠结构

• 批准号: 9346710
• 负责人: DMITRY GERASHCHENKO
• 金额: $ 34.9万
• 依托单位: MOBILE SLEEP TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9346710
• 关键词: Accidents; Acoustic Stimulation; Address; Adult; Age; Aging; Algorithms; Apple; Attention; Computer software; Data; Decision Making; Detection; Devices; Elderly; Electroencephalogram; Ensure; Frequencies; Health; Health Care Costs; Heart; Home environment; Human; Impairment; Individual; Laboratories; Laboratory Study; Legal patent; Letters; Licensing; Measurement; Measures; Memory; Neuropsychological Tests; Patients; Pattern; Physiological; Polysomnography; Population; Procedures; Production; Productivity; REM Sleep; Research; Research Personnel; Safety; Sleep; Sleep Fragmentations; Sleep Stages; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; Somatotropin; Structure; System; Technology; Testing; Time; Validation; Wrist; actigraphy; age related; base; cognitive ability; cognitive performance; executive function; fitbit; healthy volunteer; heart rate variability; improved; interest; memory consolidation; middle age; non rapid eye movement; novel; optical sensor; procedural memory; response; restoration; sleep onset; volunteer

ABSTRACT Poor sleep and memory problems are common in older adults and have considerable consequences including decreased productivity, declines in cognitive abilities, increased rate of accidents and traffic fatalities, and increased health care costs. These sleep and memory problems often occur in midlife and in older adults, when aging is associated with insomnia, fragmentation of sleep, and impairment of attention. Aging also impacts sleep stages and sleep depth, with marked changes in non-rapid eye movement (NREM) sleep, an increase in lighter NREM sleep stages (N1 or N2 stage of sleep) and a decrease in deep or “slow wave” sleep (N3 stage of sleep). Because deep sleep has been associated with the recuperative function of sleep, memory consolidation, and growth hormone release, age-related reduction in deep sleep has a negative impact on physiologic restoration, memory, and overall health. The overall objective of this proposed research is to develop a non-pharmacological means to address sleep deficiencies and well- being in older midlife adults. Several laboratory studies recently demonstrated that precisely-delivered, specific auditory stimulation in adults results in an enhancement of slow waves on the electroencephalogram (EEG) and improvement in memory. Since older adults have a significant reduction in deep sleep, increasing slow wave production by precisely-delivered auditory stimulation could be particularly useful for this population. To date, the use of auditory stimulation to improve sleep has been limited to adult volunteers in laboratory settings. Our objective is to validate, modify, and improve the application of specific auditory stimulation to increase deep sleep in older individuals, and to develop a system that can deliver slow wave sleep enhancement in the home. Both healthy people and patients with disturbances of sleep and memory could benefit from using this system. It will be especially useful in older people. Our new system will be inexpensive, simple and easy to use.

抽象的 睡眠不良和记忆问题在老年人中很常见，并且考虑了后果 包括生产率下降，认知能力下降，事故发生率和交通率的提高 死亡，增加医疗保健费用。这些睡眠和记忆问题通常发生在中年和 老年人，衰老与失眠有关，睡眠分散和注意力障碍。 衰老还会影响睡眠阶段和睡眠深度，并随着非比型眼运动的明显变化 （NREM）睡眠，较轻的NREM睡眠阶段（n1或n2睡眠阶段）的增加，深处减少 或“慢波”睡眠（N3睡眠阶段）。因为深度睡眠与恢复性有关 睡眠的功能，记忆巩固和生长马释放，与年龄相关的深度睡眠的减少 对生理恢复，记忆和整体健康有负面影响。总体目标 拟议的研究是开发一种非药理手段，以解决睡眠不足和良好的问题 在年龄较大的中年成年人。最近的一些实验室研究表明，精确交付， 成人的特定听觉刺激导致慢波增强 脑电图（EEG）和记忆的改善。由于老年人显着降低 在深度睡眠中，通过精确保存的听觉刺激增加慢波产生可能是 对这个人群特别有用。迄今为止，使用听觉刺激来改善睡眠 仅限于实验室环境中的成年志愿者。我们的目标是验证，修改和改进 应用特定的听觉刺激以增加老年人的深度睡眠，并发展 可以在家庭中提供慢波睡眠的系统。健康的人和患者 睡眠和记忆的干扰可能会受益于使用此系统。它在较旧的情况下特别有用 人们。我们的新系统将廉价，简单且易于使用。