System for providing an interface for interacting with an animal

提供与动物交互的界面的系统

• 批准号: 9339440
• 负责人: DMITRY GERASHCHENKO
• 金额: $ 16.06万
• 依托单位: NEUROTARGETING SYSTEMS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-12 至 2019-08-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9339440
• 关键词: Animal Experimentation; Animal Model; Animals; Biological; Blood Pressure Monitors; Body Weight; Brain; Cerebrovascular Circulation; Collaborations; Data; Device or Instrument Development; Devices; Electroencephalogram; Electroencephalography; Fiber Optics; Goals; Infusion procedures; Joints; Laboratory Animals; Laboratory Research; Lasers; Left; Legal patent; Light; Liquid substance; Measures; Methodology; Microdialysis; Modification; Movement; Mus; NIH Program Announcements; Optics; Paper; Pharmaceutical Preparations; Physiological; Publishing; Pump; Reporting; Research; Research Personnel; Research Project Grants; Sampling; Signal Transduction; Stress; System; Telemetry; Testing; Trademark; United States; Wireless Technology; animal welfare research; cost; design; drug discovery; experimental study; improved; interest; novel; preclinical development; research study; tool

ABSTRACT A large number of studies require sampling biological signals, stimulating the brain, or infusing test substances in freely moving mice. Although several forms of tethers are currently available for this purpose, these devices restrain the mice’s activity to some degree. The animal’s mobility is usually reduced even more when several connections are needed with the mouse (i.e., electroencephalogram (EEG)/electromyogram (EMG) wires, fiber optics, and infusion lines). Telemetric devices and miniature pumps avoid the tethers, but they still restrict the animal’s movement because they are very heavy for a mouse (i.e., smallest telemetry EEG/EMG transmitter weighs ~4 grams or ~20% of the mouse’s body weight). It is expected that restraining the mouse’s movement will negatively influence the results of the study because it would cause stress and change various physiological parameters in the mouse. We recently developed a system with optical, electrical, and fluid connections that can be used for mice or any other small animal that does not require the use of a commutator, swivel, or fiber optic rotary joint. The specific aim of this application is to modify our system for the use in studies involving connections of infusion lines with freely moving mice. Such connections are commonly used in a large number of research studies (drug infusion, microdialysis, monitoring of blood pressure, etc.). Therefore, the new modification will significantly increase the capability and commercial potential of this system. Additionally, we will adapt our system for the use in SmartCageTM, thus creating a powerful platform for drug discovery studies. It will allow for completing the research projects faster and with a lower cost.

抽象的 大量研究需要采样生物信号、刺激大脑或输注测试 自由活动的小鼠体内的物质。尽管目前有多种形式的系绳可用于此目的， 这些装置在一定程度上抑制了小鼠的活动。动物的活动能力通常会进一步降低 当需要与鼠标进行多个连接时（即脑电图（EEG）/肌电图 （肌电图）线、光纤和输液管）。遥测设备和微型泵避免了系绳，但是 它们仍然限制动物的运动，因为它们对于小鼠来说非常重（即最小的遥测 EEG/EMG 发射器重约 4 克或约小鼠体重的 20%）。预计会受到抑制 鼠标的移动会对研究结果产生负面影响，因为它会引起压力和 改变小鼠的各种生理参数。我们最近开发了一种光学系统， 电气和流体连接可用于小鼠或任何其他不需要的小动物 使用换向器、旋转接头或光纤旋转接头。该应用程序的具体目的是修改我们的 系统用于涉及将输液管与自由移动的小鼠连接的研究。这样的 连接通常用于大量研究（药物输注、微透析、 血压监测等）。因此，新的修改将显着提高能力 以及该系统的商业潜力。此外，我们将调整我们的系统以用于 SmartCageTM， 从而为药物发现研究创建了一个强大的平台。它将允许完成研究项目 更快且成本更低。