Functional Mapping of the afferent and Efferent Projections of the Superior Cervical Ganglion Interactome

本项目将绘制脑内上级颈神经节（SCG）的神经解剖学连接图， 雄性和雌性Sprague-Dawley大鼠，健康人类的模型，和神经生物学 电刺激支配颈交感神经链引起的效应 SCG我们期望扩展我们目前的工作，这表明左和右SCG有不同的 生理功能，左和右SCG在大脑内相互交谈， 协调呼吸和血压。这项工作至关重要，因为我们认为， SCG输入到大脑和身体内的关键结构的活动负责 许多炎性疾病包括睡眠呼吸暂停和夜间高血压的表达。作为 因此，我们相信，在这个项目中进行的工作将形成未来的基础， 开发新的刺激装置，将植入节后神经周围 以特异性地治疗疾病过程，所述疾病过程 通常由SCG投影抑制。

This project will map the neuroanatomical connections of the superior cervical ganglia (SCG) in both male and female Sprague-Dawley rats, a model of healthy humans, and the neurobiological effects elicited by electrical stimulation of the cervical sympathetic chains that innervate the SCGs. We expect to extend our present work that suggests that the left and right SCG have different physiological functions and that the left and right SCG talk to one another within the brain to co-ordinate breathing and blood pressure. This work is vital because we believe that a loss of activity of SCG input to the brain and key structures within the body is responsible for the expression of numerous inflammatory disorders including sleep apnea and nocturnal hypertension. As such, we are confident that the work performed in this project will form the basis of future development of novel stimulating devices that will be implanted around the post-ganglionic nerves emanating from the left and/or right SCG in order to specifically treat a disease process that is normally suppressed by the SCG projection.