Elucidating the Biogenesis of the Yersinia pestis Containing Vacuole

阐明含有液泡的鼠疫耶尔森氏菌的生物发生

基本信息

  • 批准号:
    9233902
  • 负责人:
  • 金额:
    $ 18.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-03-01 至 2019-02-28
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Yersinia pestis is a facultative intracellular pathogen that causes the disease known as plague. Growing evidence indicates that intracellular growth in macrophages is important for Y. pestis virulence. Upon phagocytosis, Y. pestis alters the maturation of the phagosome to generate a protective compartment within the cell known as the Yersinia containing vacuole (YCV). Key steps in the generation of the YCV include inhibition of YCV acidification, expansion into a spacious vacuole, and acquisition of the autophagic markers. However, the mechanisms used by the bacterium to subvert the normal phagosome maturation process and generate the YCV have not been defined. Recently we have identified a subset of host Rab GTPases that are required for Y. pestis to survive within macrophages. Because Rab proteins are key mediators of vesicular trafficking, phagosome maturation, and autophagy, we hypothesize that these GTPases are required by Y. pestis to subvert phagosome maturation and generate the YCV, thus protecting the bacterium from macrophage clearance. As Rab proteins mediate many aspects of vesicular trafficking through direct interactions with specific organelles and recruitment of effector proteins, in Aim 1 we will determine if Rab GTPase required for Y. pestis intracellular survival are specifically recruited to the YCV. In Aim 2, we will determine the contribution of individual Rab proteins on the biogenesis of the YCV. These studies will be the first to define the contribution of host Rab GTPases to the formation of the YCV. Ultimately, understanding the YCV biogenesis process will enable us to identify Y. pestis pathogenicity factors that contribute to intracellular survival.


项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Intracellular Assays to Monitor Survival and Growth of Yersinia pestis Within Macrophages.
监测巨噬细胞内鼠疫耶尔森氏菌存活和生长的细胞内测定。
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Matthew B Lawrenz其他文献

Matthew B Lawrenz的其他文献

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{{ truncateString('Matthew B Lawrenz', 18)}}的其他基金

Impact of inflammatory lipids on Yersinia pestis infection
炎性脂质对鼠疫耶尔森菌感染的影响
  • 批准号:
    10722648
  • 财政年份:
    2023
  • 资助金额:
    $ 18.84万
  • 项目类别:
Extracellular vesicles released in response to Yersinia pestis
鼠疫耶尔森菌释放细胞外囊泡
  • 批准号:
    10552010
  • 财政年份:
    2022
  • 资助金额:
    $ 18.84万
  • 项目类别:
Extracellular vesicles released in response to Yersinia pestis
鼠疫耶尔森菌释放细胞外囊泡
  • 批准号:
    10439253
  • 财政年份:
    2022
  • 资助金额:
    $ 18.84万
  • 项目类别:
Iron independent role for yersiniabactin in Yersinia pestis
耶尔森菌素在鼠疫耶尔森氏菌中的铁独立作用
  • 批准号:
    10418805
  • 财政年份:
    2021
  • 资助金额:
    $ 18.84万
  • 项目类别:
Iron independent role for yersiniabactin in Yersinia pestis
耶尔森菌素在鼠疫耶尔森氏菌中的铁独立作用
  • 批准号:
    10682967
  • 财政年份:
    2021
  • 资助金额:
    $ 18.84万
  • 项目类别:
Iron independent role for yersiniabactin in Yersinia pestis
耶尔森菌素在鼠疫耶尔森氏菌中的铁独立作用
  • 批准号:
    10789295
  • 财政年份:
    2021
  • 资助金额:
    $ 18.84万
  • 项目类别:
Iron independent role for yersiniabactin in Yersinia pestis
耶尔森菌素在鼠疫耶尔森氏菌中的铁独立作用
  • 批准号:
    10806304
  • 财政年份:
    2021
  • 资助金额:
    $ 18.84万
  • 项目类别:
Iron independent role for yersiniabactin in Yersinia pestis
耶尔森菌素在鼠疫耶尔森氏菌中的铁独立作用
  • 批准号:
    10620708
  • 财政年份:
    2021
  • 资助金额:
    $ 18.84万
  • 项目类别:
Iron independent role for yersiniabactin in Yersinia pestis
耶尔森菌素在鼠疫耶尔森氏菌中的铁独立作用
  • 批准号:
    10296752
  • 财政年份:
    2021
  • 资助金额:
    $ 18.84万
  • 项目类别:
Elucidating the Biogenesis of the Yersinia pestis Containing Vacuole
阐明含有液泡的鼠疫耶尔森氏菌的生物发生
  • 批准号:
    9110476
  • 财政年份:
    2016
  • 资助金额:
    $ 18.84万
  • 项目类别:

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