Fatigue and the Gut Microbiome of Patients Receiving Chemoradiotherapy for Rectal Cancer
接受直肠癌放化疗的患者的疲劳和肠道微生物组
基本信息
- 批准号:9327348
- 负责人:
- 金额:$ 5.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-05-01 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAdverse effectsAffectAnimalsApplications GrantsAreaAttenuatedBacteriaBacteroidesBacteroides thetaiotaomicronBehavioral SymptomsBifidobacteriumBiologicalBiomassBlood CirculationBrainCancer PatientClinical DataClinical ResearchClostridiumCollaborationsCollectionCommunitiesDataData CollectionDevelopmentDiarrheaDistressDoseEmploymentEpithelialEtiologyFatigueFecesFoundationsFutureGoalsHaptoglobinsHealthHospitalizationImmune responseImmune systemIndividual DifferencesInflammatoryInflammatory ResponseInflammatory disease of the intestineInterleukin-6InterruptionInterventionIntestinesInvestigationJournalsKnowledgeLeadLinkLipopolysaccharidesLiteratureMalignant Female Reproductive System NeoplasmMalignant NeoplasmsMediatingMentorshipMetagenomicsMethodsMicrobeMissionModelingMucous MembraneNF-kappa BNational Research Service AwardsNursesPathogenicityPatientsPeer ReviewPelvisPermeabilityPhenotypePopulationPredispositionProcessPublishingQuality of lifeRadiation therapyReactionRectal CancerReportingResearchResearch TrainingRibosomal RNARiskSamplingScienceScientistShotgunsSymbiosisSymptomsTechniquesTimeTraineeshipTrainingWritingbench to bedsidebiobehaviorcareerchemoradiationchemotherapycytokinedesignexperienceexperimental studygastrointestinal epitheliumgastrointestinal symptomgut microbiomegut microbiotahigh dimensionalityimmune activationimprovedindexinginflammatory markerinnovationlaboratory experiencemicrobialmicrobiomemicroorganismnon-compliancenovel therapeuticspatient orientedpredictive toolsprophylacticresearch data disseminationskillssymptom managementtargeted treatment
项目摘要
Abstract/Project Summary
Fatigue is one of the most distressing and commonly reported side effects of chemo-radiation (CRT), with up to
78% of rectal cancer patients complaining of severe fatigue during CRT. While the etiology and associated
mechanism of the cancer-related fatigue during CRT treatment remain elusive, it has been suggested that
dysbiosis (an imbalance in the intestinal microbiota in the gut) may contribute to worsening of fatigue during a
patients’ pelvic CRT. This study will contribute to address the knowledge gap in symptom research and the
health literature by providing initial evidence of the biologic/gut microbial processes related to the relationship
among CRT, dysbiosis, and fatigue in the rectal cancer population, so that more innovative and individualized
interventions can be developed. The proposed research is guided by a model of chemotherapy-related side
effects. The training plan was designed to allow the applicant to expand her theoretical knowledge and skills in
symptom phenotyping and conducting bio-behavioral and microbiome research in order to meet the NRSA
traineeship goals and launch a career as an independent nurse scientists. An experienced team of scientists
will lead the research training plan as related to the following objectives: (1) to enhance her understanding of
the science related to the proposed mechanism linking CRT-induced gut microbiome dysbiosis and fatigue; (2)
to increase her understanding of the characterization of CRT-related fatigue phenotypes with patient biological
and clinical data, and microbiome data collection techniques and analysis through a bedside-to-bench
approach; (3) to obtain comprehensive training and knowledge in microbiome research including stool
collection and processing, bacterial 16S rRNA amplicon sequencing, shotgun metagenomics analysis and
interpretation of microbiome-derived metagenomics data; and (4) to improve scientific writing skills and building
collaborations with experts in the field of bio-behavioral/symptom management/microbiome research to
successfully publish in high-impact, peer-reviewed journals, and submit competitive grant applications. The
training plan is for twenty four months and includes six core areas: didactic; interdisciplinary seminars;
mentorship; laboratory training; research; and dissemination. The specific aims of the proposed study are to:
Aim 1: Examine the temporal changes in diversity of the gut microbiome over the course of CRT of adults with
localized rectal cancers. Aim 1a: To investigate whether the intensity of fatigue during CRT is associated with
the gut microbial diversity changes during the course of treatment. Aim 2: Examine the temporal changes on
the abundances of specific gut microbes of adults with localized rectal cancers over the course of CRT. Aim
2a: To investigate the associations between changes in the gut microbial abundance with changes in fatigue
scores during the course of CRT. By focusing on the innovative investigation of the relationship between gut
microbial changes and fatigue symptoms during CRT, this study aligns with the mission of NINR calling for
studies on patient-centered bio-behavioral research that promote health and enhanced quality of life.
抽象/项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Velda Janet Gonzalez-Mercado其他文献
Velda Janet Gonzalez-Mercado的其他文献
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{{ truncateString('Velda Janet Gonzalez-Mercado', 18)}}的其他基金
Multi-omic Evaluation of the mTOR pathway in Radiotherapy-Related Fatigue
mTOR 通路在放射治疗相关疲劳中的多组学评估
- 批准号:
10487526 - 财政年份:2021
- 资助金额:
$ 5.9万 - 项目类别:
Multi-omic Evaluation of the mTOR pathway in Radiotherapy-Related Fatigue
mTOR 通路在放射治疗相关疲劳中的多组学评估
- 批准号:
10282354 - 财政年份:2021
- 资助金额:
$ 5.9万 - 项目类别:
Multi-omic Evaluation of the mTOR pathway in Radiotherapy-Related Fatigue
mTOR 通路在放射治疗相关疲劳中的多组学评估
- 批准号:
10665092 - 财政年份:2021
- 资助金额:
$ 5.9万 - 项目类别:
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