Michigan Center on Lifestage Environmental Exposures and Disease

 描述(由申请人提供) 这是密歇根大学环境健康科学(EHS)核心中心在最初四年的最后一年提交的第一份竞争性续签申请 NIEHS支持。该中心围绕作为疾病重要决定因素的环境暴露易感性的关键窗口这一主题而组织，形成了密歇根生命环境暴露和疾病中心(M-LEEAD)。本申请中使用的生命阶段是指临床公认的发育、中年和衰老阶段，涉及生命的先孕、产前、婴儿、儿童、青少年、生育年龄成人和老年成人阶段。该中心建立在密歇根大学在环境公共卫生这一新兴领域的研究活动和支持的坚实基础上，16笔NIEHS赠款进入下一个资助期，其中包括儿童环境健康和疾病预防研究中心以及参与超级基金研究计划中心。M-LEEAD的使命是加速研究，确定生命脆弱阶段环境暴露的影响，并促进将这些发现转化为改善医疗和公共卫生干预措施，以减轻慢性病。该中心通过采用新的跨学科方法对现有和新的研究人员提供基础设施支持来执行其使命，这些方法增加了对环境暴露针对生命脆弱阶段的机制的了解。对研究的支持是通过综合中心计划提供的，其中包括一个试点项目计划、三个设施核心和三个研究团队，以创造协同效应来刺激创新研究。设施的核心是：1)综合健康科学核心(IHSC)；2)暴露评估核心(EAC)；以及3)OMICS和生物信息学核心(OBIC)。研究团队围绕疾病的关键机制途径组成：1)炎症和氧化应激；2)基因组学和表观基因组学；以及3)内分泌和新陈代谢中断。研究与利益相关者社区的参与相结合，通过社区外联和参与核心(COEC)，并通过中心职业发展计划培训未来的EHS领导者。该中心的运作由一个行政核心监督。M-LEEAD通过以下具体目标努力完成其使命：1)整合和建立现有的机构方案和设施，以提供结构和资源，促进对环境暴露、人类生物学和疾病之间复杂关系的理解；2)促进跨传统学科边界的研究人员之间的整合、协调和合作，以开展高质量的研究，从而改进预防环境诱发疾病的战略；3)通过支持处于关键职业阶段的科学家，特别是处于职业生涯早期和中期的科学家，建立方案和科学能力，参与解决环境健康中关键的、新出现的问题的研究；4)与受影响的社区进行双向互动，以确定社区环境健康问题，并将研究成果转化为社区参与机会。

 DESCRIPTION (provided by applicant) This is the first competing renewal application for the Environmental Health Sciences (EHS) Core Center at the University of Michigan, submitted in the final year of the initial four years of NIEHS support. The Center is organized around the theme of critical windows of susceptibility to environmental exposures as important determinants of disease, forming the Michigan Center of Lifestage Environmental Exposures and Disease (M- LEEaD). Lifestage, as used in this application, refers to clinically-recognized stages of development, mid-life, and aging that pertain to the preconception, prenatal, infant, child, adolescent, reproductive age adult, and aging adult periods of life. The Center builds on a strong foundation of research activity and support at the University of Michigan in this emergent arena of environmental public health, with 16 NIEHS grants moving into the next funding period that includes a Children's Environmental Health and Disease Prevention Research Center and participation in a Superfund Research Program Center. The mission of M-LEEaD is to accelerate research that defines impacts of environmental exposures during vulnerable stages of life, and to promote translation of these findings to improve medical and public health interventions for the mitigation of chronic disease. The Center implements its mission through infrastructural support of established and new investigators applying novel transdisciplinary approaches that increase understanding of mechanisms by which environmental exposures target vulnerable stages of life. Support for research is provided through integrated Center programs that include a Pilot Project Program, three Facility Cores, and three Research Teams to create synergy for stimulation of innovative research. The Facility Cores are: 1) Integrated Health Sciences Core (IHSC); 2) Exposure Assessment Core (EAC); and 3) Omics and Bioinformatics Core (OBIC). Research Teams are organized around key mechanistic pathways of disease: 1) Inflammation & Oxidative Stress; 2) Genomics & Epigenomics; and, 3) Endocrine & Metabolic Disruption. Research is coupled with the engagement of stakeholder communities through the Community Outreach and Engagement Core (COEC) and training of future leaders in EHS through the Center Career Development Program. The functioning of the Center is overseen by an Administrative Core. M-LEEaD strives to accomplish its mission through the following specific aims: 1) Integrate and build upon existing institutional programs and facilities to provide structure and resources that accelerate understanding of the complex relationships among environmental exposures, human biology, and disease; 2) Foster integration, coordination, and cooperation among investigators across traditional disciplinary boundaries to conduct high-quality research that translates to improved strategies towards preventing environmentally-induced disorders; 3) Build programmatic and scientific capacity through support for scientists at critical career stages, but especially those at early- and mid-career stages, to engage in research that addresses critical, emerging questions in environmental health; and, 4) Interact with affected communities in a bidirectional manner to identify community environmental health concerns and to translate research findings into community engagement opportunities.