Michigan Center on Lifestage Environmental Exposures and Disease

 描述（由申请人提供） 这是密歇根大学环境健康科学 (EHS) 核心中心的第一份竞争性更新申请，于最初四年的最后一年提交。 NIEHS 支持。 该中心围绕“环境暴露易感性关键窗口作为疾病的重要决定因素”这一主题进行组织，形成了密歇根生命阶段环境暴露和疾病中心 (M-LEEaD)。 如本申请中所使用的，生命阶段是指与生命的孕前、产前、婴儿、儿童、青少年、育龄成人和老年阶段相关的临床认可的发育阶段、中年阶段和衰老阶段。 该中心建立在密歇根大学在环境公共卫生这一新兴领域的研究活动和支持的坚实基础上，16 项 NIEHS 赠款将进入下一个资助期，其中包括儿童环境健康和疾病预防研究中心以及参与超级基金研究计划中心。 M-LEEaD 的使命是加速研究，确定生命脆弱阶段环境暴露的影响，并促进这些研究结果的转化，以改善医疗和公共卫生干预措施，以缓解慢性病。该中心通过为现有的和新的研究人员提供基础设施支持来履行其使命，他们应用新颖的跨学科方法，增进对环境暴露针对生命脆弱阶段的机制的理解。通过综合中心计划提供研究支持，其中包括试点项目计划、三个设施核心和三个研究团队，以创造协同效应来刺激创新研究。设施核心是： 1) 综合健康科学核心 (IHSC)； 2）暴露评估核心（EAC）； 3) 组学和生物信息学核心（OBIC）。研究团队围绕疾病的关键机制途径组织起来：1）炎症和氧化应激； 2）基因组学和表观基因组学；以及，3) 内分泌和代谢紊乱。 研究与利益相关者社区通过社区外展和参与核心 (COEC) 的参与相结合，并通过中心职业发展计划对未来 EHS 领导者进行培训。该中心的运作由行政核心监督。 M-LEEaD 努力通过以下具体目标来完成其使命： 1) 整合和建立现有的机构计划和设施，提供结构和资源，加速对环境暴露、人类生物学和疾病之间复杂关系的理解； 2) 促进跨传统学科界限的研究人员之间的整合、协调和合作，以开展高质量的研究，从而转化为预防环境引起的疾病的改进策略； 3) 通过支持处于关键职业阶段的科学家，特别是处于职业生涯早期和中期阶段的科学家，建设规划和科学能力，以从事解决环境健康中关键的、新出现的问题的研究； 4) 以双向方式与受影响社区互动，以确定社区环境健康问题并将研究结果转化为社区参与机会。

 DESCRIPTION (provided by applicant) This is the first competing renewal application for the Environmental Health Sciences (EHS) Core Center at the University of Michigan, submitted in the final year of the initial four years of NIEHS support. The Center is organized around the theme of critical windows of susceptibility to environmental exposures as important determinants of disease, forming the Michigan Center of Lifestage Environmental Exposures and Disease (M- LEEaD). Lifestage, as used in this application, refers to clinically-recognized stages of development, mid-life, and aging that pertain to the preconception, prenatal, infant, child, adolescent, reproductive age adult, and aging adult periods of life. The Center builds on a strong foundation of research activity and support at the University of Michigan in this emergent arena of environmental public health, with 16 NIEHS grants moving into the next funding period that includes a Children's Environmental Health and Disease Prevention Research Center and participation in a Superfund Research Program Center. The mission of M-LEEaD is to accelerate research that defines impacts of environmental exposures during vulnerable stages of life, and to promote translation of these findings to improve medical and public health interventions for the mitigation of chronic disease. The Center implements its mission through infrastructural support of established and new investigators applying novel transdisciplinary approaches that increase understanding of mechanisms by which environmental exposures target vulnerable stages of life. Support for research is provided through integrated Center programs that include a Pilot Project Program, three Facility Cores, and three Research Teams to create synergy for stimulation of innovative research. The Facility Cores are: 1) Integrated Health Sciences Core (IHSC); 2) Exposure Assessment Core (EAC); and 3) Omics and Bioinformatics Core (OBIC). Research Teams are organized around key mechanistic pathways of disease: 1) Inflammation & Oxidative Stress; 2) Genomics & Epigenomics; and, 3) Endocrine & Metabolic Disruption. Research is coupled with the engagement of stakeholder communities through the Community Outreach and Engagement Core (COEC) and training of future leaders in EHS through the Center Career Development Program. The functioning of the Center is overseen by an Administrative Core. M-LEEaD strives to accomplish its mission through the following specific aims: 1) Integrate and build upon existing institutional programs and facilities to provide structure and resources that accelerate understanding of the complex relationships among environmental exposures, human biology, and disease; 2) Foster integration, coordination, and cooperation among investigators across traditional disciplinary boundaries to conduct high-quality research that translates to improved strategies towards preventing environmentally-induced disorders; 3) Build programmatic and scientific capacity through support for scientists at critical career stages, but especially those at early- and mid-career stages, to engage in research that addresses critical, emerging questions in environmental health; and, 4) Interact with affected communities in a bidirectional manner to identify community environmental health concerns and to translate research findings into community engagement opportunities.