Core Laboratory for Advanced PET and MRI image analysis

先进PET和MRI图像分析核心实验室

• 批准号: 9421244
• 负责人: Mark Muzi
• 金额: $ 24.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9421244
• 关键词: American College of Radiology Imaging Network; Avidity; Biochemical Pathway; Biochemistry; Brain Neoplasms; Clinical Oncology; Clinical Trials; Collaborations; Communities; Data; Data Analyses; Dose; Eastern Cooperative Oncology Group; European Organization for Research and Treatment of Cancer; Foundations; Funding; Glioma; Goals; Grant; Head and neck structure; Human; Image; Image Analysis; International; Journals; Kinetics; Laboratories; Magnetic Resonance Imaging; Malignant Neoplasms; Manuscripts; Medical; Medical Imaging; Metadata; Methods; Modeling; PET/CT scan; Patients; Positron-Emission Tomography; Protocols documentation; Provider; Public Health; Publishing; Radiation; Radiology Specialty; Research; Research Personnel; Science; Services; Tilia; Tracer; United States National Institutes of Health; Universities; Wages; Washington; Work; animal imaging; cancer imaging; career; cost; data management; design; experimental study; human imaging; imaging program; imaging study; innovation; meetings; member; models and simulation; novel strategies; oncology; programs; quantitative imaging; radiotracer; reconstruction; simulation; working group

ABSTRACT: The goal of this proposal is to provide technically-advanced support for the specific aims of NCI- funded projects for medical imaging affiliated with the University of Washington, the NCI Quantitative Imaging Network (QIN), and the NCTN ECOG-ACRIN cooperative group. My medical imaging career began at UW in 1985, where I was fortunate to work with Drs. Michael Graham and Alex Spence, who laid the foundation for quantitative analysis and clinical oncology, respectively. My early work in PET imaging revolved around managing animal imaging projects, a full biochemistry lab and a nascent human PET glioma imaging program. As PET imaging developed under the PET Program Project (P01-CA042045, KA Krohn, PI), we transitioned to human imaging and clinical trials research, probing different biochemical pathways using numerous PET radiotracers. I developed an avidity for compartmental modeling analysis of kinetic image data, initially with guidance from Drs. James Bassingwaithe, Michael Graham and Finbarr O'Sullivan, and later in collaboration with Drs. Tony Shields, David Mankoff, Janet Eary, Hannah Linden and Paul Kinahan, all of them funded by NCI grants. I am currently Director of the Imaging Core lab and a member of Paul Kinahan's U01 grant. I have responsibility for participating in the image analysis working groups of the QIN, extended planning of PET imaging projects, imaging protocols and designing data analysis methods for new experiments. I am a senior contributor to our overall program as well as a provider of novel approaches to data management, quantitative image analysis and data simulations for numerous cancer projects in Radiology and Oncology. Due to the cost of imaging, the radiation dose and other issues, my personal ambition is to extract as much quantitative information as possible from well-designed and executed cancer imaging studies using PET radiotracers and advanced MR methods. My career goal is to provide independent, but collaborative, support for the specific aims of NCI grants for medical imaging projects at with UW, the QIN and ECOG-ACRIN. Additionally, I have national recognition as manager of the ACRIN-UW PET Core Lab, member of the ECOG-ACRIN Head and Neck, Experimental Imaging Sciences and Brain Tumor Committees, and a key member of the NIH-Cancer Imaging Program's QIN Working Groups. The innovative protocols I developed for dynamic imaging are a substantial improvement for extracting quantitative information from dynamic PET, and are now a national clinical trials standard. I routinely present my advanced PET imaging results at national and international scientific meetings (EORTC, SNMMI, WMIC, ACRIN and QIN/NCI) and publish/review manuscripts annually in medical journals. In summary, I have developed a nationally recognized advanced lab for PET image analysis, funded entirely through NCI grants for 30 years. The overall benefit NCI receives for sharing my labor across NCI funded projects will have an impact on current and new investigators, providing them with quantitative methods of analysis for PET/CT and MRI image data using robust, repeatable and validated methods.

摘要：本提案的目的是为NCI的具体目标提供先进的技术支持- 资助项目的医学成像附属于华盛顿大学，国家癌症研究所定量成像 网络（QIN）和NCTN ECOG-ACRIN合作组。我的医学成像生涯始于年在华盛顿大学 1985年，我有幸与迈克尔·格雷厄姆博士和亚历克斯·斯宾塞博士一起工作，他们为 定量分析和临床肿瘤学。我在PET成像方面的早期工作围绕着 管理动物成像项目，一个完整的生物化学实验室和一个新生的人类PET胶质瘤成像计划。 由于PET成像是在PET程序项目（P01-CA 042045，KA克罗恩，PI）下开发的，我们过渡到 人体成像和临床试验研究，使用多种PET探测不同的生化途径 放射性示踪剂我开发了一种对动力学图像数据的房室建模分析的热情，最初使用 James Bassingwaithe、Michael Graham和Finbarr O 'Sullivan博士的指导，以及后来的合作 托尼·希尔兹、大卫·曼考夫、珍妮特·埃里、汉娜·林登和保罗·基纳汉博士，他们都是由 国家癌症研究所赠款。我目前是成像核心实验室的主任，也是Paul Kinahan U 01基金的成员。我有 负责参与QIN的图像分析工作组，PET的扩展计划 成像项目，成像协议和设计新实验的数据分析方法。我是高级 贡献者，我们的整体计划，以及提供新的方法来数据管理，定量 为放射学和肿瘤学中的众多癌症项目提供图像分析和数据模拟。由于成本 成像，辐射剂量和其他问题，我个人的目标是提取尽可能多的定量 使用PET放射性示踪剂，尽可能从精心设计和执行的癌症成像研究中获得信息， 先进的MR技术。我的职业目标是提供独立的，但协作，支持的具体 NCI赠款医学成像项目的目的是与UW，QIN和ECOG-ACRIN合作。另外，我有 作为ACRIN-UW PET核心实验室的经理，ECOG-ACRIN负责人的成员， Neck，实验成像科学和脑肿瘤委员会，以及NIH癌症的主要成员 图像程序的QIN工作组。我为动态成像开发的创新协议是 从动态PET中提取定量信息的实质性改进，现在是国家 临床试验标准。我定期在国家和国际会议上展示我的先进PET成像结果， 科学会议（EORTC、SNMMI、WMIC、ACRIN和QIN/NCI），并每年在 医学期刊综上所述，我已经建立了一个全国公认的先进的PET图像分析实验室， 30年来完全由NCI赠款资助。NCI因分享我的劳动而获得的整体收益 NCI资助的项目将对现有和新的研究人员产生影响，为他们提供定量的 PET/CT和MRI图像数据的分析方法，使用稳健、可重复和经验证的方法。