Core Laboratory for Advanced Cancer Image Analysis

先进癌症图像分析核心实验室

• 批准号: 10515931
• 负责人: Mark Muzi
• 金额: $ 28.28万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10515931
• 关键词: Advanced Malignant Neoplasm; American College of Radiology Imaging Network; Avidity; Biochemical Pathway; Biochemistry; Brain Neoplasms; Clinical Trials; Collaborations; Communities; Consultations; Data; Data Analyses; Data Reporting; Development; Eastern Cooperative Oncology Group; Ensure; European Organization for Research and Treatment of Cancer; Foundations; Funding; Goals; Grant; Head and neck structure; Human; Image; Image Analysis; Information Management; International; Laboratories; Magnetic Resonance Imaging; Malignant Neoplasms; Manuscripts; Medical Imaging; Metadata; Methodology; Methods; Oncology; PET/CT scan; Patient imaging; Patients; Peer Review; Pennsylvania; Positron-Emission Tomography; Procedures; Protocols documentation; Provider; Publications; Publishing; Radiation Dose Unit; Research; Research Personnel; Structure; Tilia; Tracer; Universities; Washington; Work; animal imaging; cancer imaging; career; cost; design; human imaging; image processing; imaging program; imaging study; innovation; kinetic model; meetings; member; models and simulation; novel; programs; quantitative imaging; radiomics; reconstruction; simulation; symposium; technical writing; working group

1 ABSTRACT: The goal of this proposal is to provide technically-advanced support for the specific aims of 2 selected NCI-funded projects for medical imaging affiliated with the University of Washington (UW), The 3 University of Pennsylvania, the NCI Quantitative Imaging Network (QIN), and the NCTN ECOG-ACRIN 4 cooperative group. My medical imaging career began at UW in 1985, where I was fortunate to work with Drs. 5 Michael Graham and Alex Spence, who laid the foundation for quantitative analysis in oncology. My early work 6 in PET imaging revolved around managing animal imaging projects, a full biochemistry lab and a nascent 7 human PET imaging program. As PET imaging developed under NCI grant P01-CA042045 (PI; Krohn, KA), 8 we transitioned to human imaging and clinical trials research, probing various biochemical pathways using 9 many PET tracers. I developed avidity for kinetic modeling of dynamic PET image data, initially with Drs. 10 James Bassingwaithe and Michael Graham, and later in collaboration with Drs. Tony Shields, David Mankoff, 11 Janet Eary, Hannah Linden and Paul Kinahan, all of them funded by NCI grants. As an NCI R50 recipient 12 (R50-CA270211), I am currently Director of a Core Laboratory for Advanced image analysis and a member of 13 Dr. Kinahan’s U24 (U24-CA264044) CIRP team. I have responsibility for participating in working groups of the 14 QIN, CIRP, planning PET imaging projects, imaging protocols and designing novel data analysis methods. I 15 am a senior contributor to our UW program as well as a provider of innovative approaches to quantitative 16 image analysis and data simulations for numerous cancer imaging projects. Due to the cost of imaging, 17 radiation dose and other issues, my personal ambition is to extract as much quantitative information as 18 possible from well-designed and executed cancer imaging studies. My career goal is to provide independent, 19 but collaborative, support for the specific aims of NCI grants for medical imaging projects at UW, UPenn, the 20 QIN, CIRP and ECOG-ACRIN. Additionally, I have national recognition as manager of the ECOG-ACRIN-UW 21 PET Core Lab, a member of the ECOG-ACRIN Head & Neck, Experimental Imaging, Radiomics, Quantitative 22 Imaging and Brain Tumor Committees, and a key member of the NCI/CIP QIN Working Groups. The innovative 23 protocols I developed for dynamic imaging are a substantial improvement for extracting quantitative information 24 from dynamic PET, and are now a national clinical trials standard. I routinely present my advanced PET 25 imaging results at national and international scientific meetings (EORTC, SNMMI, WMIC, EMIM, IEEE, ECOG- 26 ACRIN and QIN/NCI) and publish/review manuscripts annually. Over the last R50 period I had 26 publications, 27 6 data reports and 40 presentations. In summary, I have developed a nationally recognized advanced lab for 28 image analysis, funded entirely through NCI grants for 35 years. The overall benefit NCI receives for sharing 29 my labor across NCI projects will have an impact on current and new investigators, providing them with 30 quantitative methods for PET/CT and MRI cancer image data using robust, repeatable and validated methods.

1摘要：本提案的目的是为以下具体目标提供技术先进的支持 2个选定的NCI资助的附属于华盛顿大学的医学成像项目， 3宾夕法尼亚大学、NCI定量成像网络(QIN)和NCTN ECOG-ACRIN 4合作组。我的医学成像生涯始于1985年在威斯康星大学，在那里我有幸与Dr。 5迈克尔·格雷厄姆和亚历克斯·斯宾塞，他们为肿瘤学的定量分析奠定了基础。我的早期作品 6在PET成像方面，围绕着管理动物成像项目，一个完整的生化实验室和一个新成立的 7人体正电子发射计算机断层显像程序。根据NCI授权P01-CA042045(PI；Krohn，KA)开发的PET成像， 8我们过渡到人体成像和临床试验研究，使用 9多种PET示踪剂。一开始，我与Dr。 10詹姆斯·巴辛瓦特和迈克尔·格雷厄姆，后来与托尼·希尔兹博士，大卫·曼科夫合作， 11珍妮特·埃里、汉娜·林登和保罗·基纳汉，他们都是由NCI拨款资助的。作为NCI R50收件人 12(R50-CA270211)，我目前是高级图像分析核心实验室的主任和 13基纳汉博士的U24(U24-CA264044)CIRP团队。我有责任参加国际货币基金组织 14秦，CIRP，规划PET成像项目，成像协议和设计新的数据分析方法。我 15 AM是我们UW计划的高级贡献者，也是量化的创新方法的提供者 16个用于众多癌症成像项目的图像分析和数据模拟。由于成像的成本， 17辐射剂量和其他问题，我个人的抱负是提取尽可能多的定量信息 18个可能来自精心设计和执行的癌症成像研究。我的职业目标是提供独立、 19但协作，支持NCI赠款的特定目标，用于UW，UPenn，the 20秦、CIRP和ECOG-ACRIN。此外，作为ECOG-ACRIN-UW的经理，我得到了全国的认可 21 PET核心实验室，ECOG-ACRIN Head&Neck成员，实验成像，放射组学，定量 22个影像和脑肿瘤委员会，以及NCI/CIP Qin工作组的关键成员。创新的 我为动态成像开发的23个协议在提取定量信息方面有了实质性的改进 24来自动态正电子发射计算机断层扫描，现已成为国家临床试验标准。我经常展示我的高级PET 在国家和国际科学会议(EORTC、SNMMI、WMIC、EMIM、IEEE、ECOG- 26 ACRIN和QIN/NCI)，每年出版/审稿。在过去的R50期间，我有26种出版物， 27 6份数据报告和40份演示文稿。总之，我开发了一个国家认可的先进实验室，用于 28图像分析，完全由NCI赠款资助，为期35年。NCI因共享而获得的总体收益 29我在NCI项目中的劳动力将对现有和新的调查人员产生影响，为他们提供 使用稳健、可重复和经过验证的方法对PET/CT和MRI癌症图像数据进行30种定量方法。