Annual International Primary CNS Lymphoma Collaborative Group Meeting

项目摘要 原发性中枢神经系统淋巴瘤(PCNSL)是非霍奇金淋巴瘤(NHL)的结外变异型 这仅限于神经系统。PCNSL的诊断和治疗方法不同 与那些适用于其他形式的非霍奇金淋巴瘤或其他脑癌的药物不同。国际小学中心 神经系统淋巴瘤协作小组(IPCG)由来自多个国家和地区的专家组成 致力于研究PCNSL的学科。IPCG在美国举行年度科学会议 血液学学会会议，讨论与PCNSL相关的各种研究课题。一个 每年由一个执行委员会选出正在讨论的主题的国际专家担任主席 科学会议。这些会议导致了多个合作项目，并产生了积极的影响 这一领域的研究成果已发表在同行评议文献中。IPCG年度会议是一个至关重要的 为这种独特的脑癌和淋巴瘤产生新的想法和方法的论坛。2016年 会议主题是老年PCNSL患者的管理。确诊为PCNSL的中位年龄为 65但许多临床试验排除了老年患者的参与。合并症和增加的风险 神经毒性限制了大剂量化疗和全脑放射等激进疗法的应用 这群人。专门针对老年人PCNSL的临床试验有限，这代表着一种未得到满足的医学 需要。关于这一问题的一次会议是政府间气候变化框架小组的高度优先事项。

Project Summary Primary central nervous system lymphoma (PCNSL) is an extranodal variant of non-Hodgkin lymphoma (NHL) that is confined to the nervous system. The diagnostic and therapeutic approaches to PCNSL are different from those that are applied to other forms of NHL or to other brain cancers. The International Primary Central Nervous System Lymphoma Collaborative Group (IPCG) consists of specialists from multiple countries and disciplines dedicated to the study of PCNSL. The IPCG holds an annual scientific conference at the American Society of Hematology meeting in which various research topics related to PCNSL are discussed. An international expert on the topic under discussion is selected each year by an executive committee to chair the scientific conference. These meetings have led to multiple collaborative projects that have positively impacted the field and that have been published in the peer-reviewed literature. The annual IPCG meeting is a critical forum for generating new ideas and approaches to this unique form of brain cancer and lymphoma. The 2016 conference topic is Management of Elderly Patients with PCNSL. The median age at diagnosis of PCNSL is 65 but many clinical trials exclude elderly patients from participation. Co-morbidities and increased risk of neurotoxicity limit application of aggressive therapies like high-dose chemotherapy and whole brain radiation in this population. Clinical trials specifically for elderly PCNSL are limited and this represents an unmet medical need. A conference focused on this problem is of high priority for the IPCG.