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Plant-based compounds as Radionuclide Decorporation Agents AND Mechanisms Involved in Radiation Sensitivity

植物基化合物作为放射性核素脱色剂和涉及辐射敏感性的机制

批准号：

9574591

负责人：

金额：

$13.03万

依托单位：

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/9574591

关键词：

Binding Biological Models Curcumin Genistein Inflammation Insulin-Like Growth Factor I Lentinula edodes Metals Miniature Swine Mus Oxidative Stress Pathway interactions Plants Quercetin Radiation Radiation Tolerance Radioisotopes aqueous base beta-Glucans cytotoxicity endothelial dysfunction in vitro Model irradiation metal chelator

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英文摘要

This IAA will be composed of 2 projects. Project 1 will examine if plant-based compounds (such as genistein, quercetin, and curcumin, as well as lentinan, a β-glucan compound derived from shiitake mushrooms), can be used as non-toxic radiation decorporation agents. Project 2 will examine the positive association between activity of the IGF-1/Akt/eNOS pathway and survival in two minipig strains (Gottingen and Sinclair MP) with different sensitivity to irradiation, and extend the generalizability of the finding to a different species (mice).

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