Role of prenatal environment in psychopathology risk in preschool aged children of Mexican descent

产前环境在墨西哥裔学龄前儿童精神病理学风险中的作用

• 批准号: 9232543
• 负责人: Kimberly Lynn D'Anna-Hernandez
• 金额: $ 44.7万
• 依托单位: CALIFORNIA STATE UNIVERSITY SAN MARCOS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9232543
• 关键词: 5 year old; Acute; Address; Adrenal Glands; Affect; Age; Attitude; Behavior; Behavioral; Biological Assay; Biological Factors; Birth; California; Child; Child Behavior Checklist; Child Mental Health; Childhood; Chronic; Chronic stress; Collection; Communities; Data; Development; Discrimination; Early identification; Emotional; Environment; Exposure to; Family; Foundations; Funding; Future; General Population; Goals; Grant; Hair; Hydrocortisone; Hypothalamic structure; Immigrant; Infant; Intervention; Laboratories; Language; Lead; Life; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental Health; Mental disorders; Mexican; Mexican Americans; Mexico; Mission; Mood Disorders; Moods; Mothers; National Institute of Mental Health; Neonatal; Neurosecretory Systems; Nursery Schools; Outcome; Participant; Performance; Perinatal; Physiological; Physiology; Pituitary Gland; Play; Population; Positioning Attribute; Pregnancy; Preschool Child; Problem behavior; Psychology; Psychopathology; Public Health; Recruitment Activity; Reporting; Research; Risk; Role; Saliva; Salivary; Sampling; Strategic Planning; Stress; Students; Symptoms; Temperament; Testing; Time; Translational Research; Underserved Population; Universities; Woman; aged; antepartum depression; career; cohort; depressive symptoms; design; disorder risk; early childhood; emotional symptom; experience; fetal; health disparity; high risk; hypothalamic-pituitary-adrenal axis; in utero; infancy; insight; maternal depression; maternal stress; minority student; novel; offspring; postnatal; pregnant; prenatal; prenatal exposure; prenatal stress; professor; programs; prospective; racial and ethnic; social; stressor

Project Summary The PI is currently an Assistant Professor in the Department of Psychology at California State University San Marcos. Her long-term goal is to sustain an independent research career examining mechanisms between socio-cultural factors, maternal affect and child outcomes related to mood dysregulation in the perinatal period. The aim of the proposed research is to examine the associations between prenatal exposure to maternal stressors related to cultural adaptation and maternal mental health and subsequent risk of presence of mood dysregulation in preschool aged children as measured by physiological stress vulnerability, emotional reactivity and depressive symptoms in the vulnerable US Mexican population. Prenatal factors have already been collected with a previous AREA grant R15 MH099-498-01A1 (maternal stress, depression and fetal and infant hypothalamic pituitary adrenal [HPA] axis activity). This proposal will follow the same participants and include 2 postnatal assessments of preschool children aged 3-5 years old. Three hypotheses will be tested: 1) greater prenatal exposure to maternal cultural stress and depression will be associated with greater increased negative emotionality and depressive-like symptoms in young children; 2) increased prenatal exposure to maternal cultural stress and depression will be related to increased child hypothalamic pituitary adrenal (HPA) axis as measured by hair cortisol, a non-invasive chronic stress measure, and blunted acute salivary cortisol; 3) cortisol levels that increase over childhood from infancy to preschool aged will be associated with greater negative emotionality and depressive symptoms. With information gained and prenatal information previously collected, we will also determine if fetal cortisol levels moderate or mediate the relationship between maternal variables and child risk/presence of mood dysregulation. The proposed research will follow 126 women of Mexican descent and their children previously recruited during pregnancy. This research has direct consequences for public health as the Mexican-American population is the most rapidly growing group in the US and Mexican-American children are exposed to high levels of stressors beginning in utero, which places them at increased risk for mood dysregulation. Socio-cultural variables may play a role in this increased risk, specifically stress related to cultural adaptation (acculturative stress, discrimination). However, if and the mechanism by which this occurs is unknown. Students will be directly involved at all levels of the project including recruitment and retention of participants, saliva and hair collection, child temperament and symptom assessment, sample management and performance of cortisol assays. The project will provide critical translational research experience for students, with an emphasis on encouraging racial/ethnic minority students, in line with the missions of AREA. This study directly addresses the role of environment and health disparities, two crossing cutting them in the NIMH strategic plan, in risk for mental health disorders in a vulnerable underserved population and provides a foundation that can lead to prenatal and preschool interventions directed toward socio-cultural factors in the high-risk Mexican-American population.

项目摘要 PI目前是加州州立大学旧金山分校心理学系的助理教授。 马科斯她的长期目标是维持一个独立的研究生涯，研究 社会文化因素，母亲的影响和儿童的结果与围产期情绪失调。 这项研究的目的是检查产前暴露与母体暴露之间的关系。 与文化适应和母亲心理健康相关的压力源以及随后出现情绪的风险 通过生理应激脆弱性、情绪反应性、 和抑郁症状的研究产前因素已经被 收集与以前的区域赠款R15 MH 099 -498- 01 A1（产妇压力，抑郁症和胎儿和婴儿 下丘脑垂体肾上腺[HPA]轴活动）。该提案将遵循相同的参与者，包括2 对3-5岁学龄前儿童进行产后评估。将检验三个假设：1） 产前暴露于母亲的文化压力和抑郁症将与更大的增加 幼儿的负面情绪和抑郁样症状; 2）产前暴露增加 母亲的文化压力和抑郁将与儿童下丘脑垂体肾上腺（HPA）增加有关 通过毛发皮质醇（一种非侵入性慢性压力测量方法）和钝化的急性唾液皮质醇测量轴; 3)皮质醇水平从婴儿期到学龄前儿童期的增加将与更大的 消极情绪和抑郁症状。根据之前获得的信息和产前信息 收集，我们还将确定胎儿皮质醇水平是否适度或介导母体皮质醇水平之间的关系。 变量和儿童风险/情绪失调的存在。这项研究将跟踪126名女性， 墨西哥裔及其在怀孕期间曾被招募的子女。这项研究直接 墨西哥裔美国人是美国人口增长最快的群体， 美国和墨西哥裔美国儿童从子宫内开始就暴露在高水平的压力源中， 他们情绪失调的风险增加。社会文化变量可能在这种风险增加中发挥作用， 特别是与文化适应有关压力（文化适应压力、歧视）。然而，如果和 这种情况发生的机制尚不清楚。学生将直接参与项目的各个层面 包括招募和保留参与者、唾液和毛发收集、儿童气质和症状 皮质醇测定的评估、样品管理和性能。该项目将提供关键的 学生的翻译研究经验，重点是鼓励种族/少数民族 学生们，在符合地区的使命。这项研究直接涉及环境和健康的作用 差异，两个交叉切割他们在NIMH战略计划，在精神健康障碍的风险， 弱势群体，并提供了一个基础，可以导致产前和学前教育 针对高危墨西哥裔美国人人群的社会文化因素进行干预。