NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCI
NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCI
批准号:
9622527
负责人:
Christopher Martens
金额:
$12.73万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-07-15 至 2022-03-31
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
CANDIDATE: Christopher R. Martens, Ph.D., is a postdoctoral fellow in Integrative Physiology at the University
of Colorado Boulder. In this K01 application, Dr. Martens aims to study the efficacy of a novel NAD+ boosting
and calorie restriction-mimetic compound, nicotinamide riboside (NR), for improving memory and
cerebrovascular function in older adults with amnestic mild cognitive impairment (aMCI). His immediate goal is
to acquire the research training and professional skills necessary to transition from a postdoctoral fellow to an
independent academic investigator. His long-term goal is to establish his own extramurally funded research
program, with a primary focus on identifying therapeutic strategies for treating cerebrovascular dysfunction,
improving cognitive function and reducing the risk Alzheimer's disease (AD) in older adults. CAREER
DEVELOPMENT PLAN: Dr. Martens proposes to enhance his career development by: 1) acquiring new
experimental skills in the assessment of cognitive and cerebrovascular function to support his proposed
research plan; 2) receiving further training in MCI and AD pathophysiology, geriatrics and biostatistics; and 3)
refining his professional skills development including formal course work, attendance and presentations at
weekly journal clubs, university seminars, national scientific meetings, and Neurology and Geriatric Grand
Round Series, and through regular interactions with his mentoring team. ENVIRONMENT: Dr. Martens will train
in an outstanding environment supported by a multi-disciplinary team of mentors who will provide him with
research and career development training. The principal mentor, Dr. Seals, is an internationally recognized and
NIA-funded scientist with a strong record of successful mentoring in biomedical research pertaining to aging and
vascular dysfunction. Co-Mentor Dr. Hughson is a leading expert in the assessment of cerebrovascular
function and brain aging, and Dr. Bettcher is has extensive experience assessing cognitive function in patients
with MCI. Dr. McQueen is director of biostatistics at the CU-Boulder Clinical and Translational Research Center
(CTRC) and has extensive experience providing mentoring and consulting to trainees and faculty members
conducting clinical trials. Co-mentors Dr. Potter and Dr. Schwartz are senior NIA investigators with expertise in
Alzheimer's disease and geriatric medicine, respectively, and will provide mentorship to complement the
research training & objectives. The mentorship team will provide specific expertise in key areas of the proposed
research project and overall training plan. RESEARCH: aMCI is the earliest symptomatic stage in the
development of AD, which is among the fastest growing causes of death in the US. aMCI is associated with
impaired cerebrovascular function, which likely contributes to cognitive impairment and leads to increased risk
of AD-related dementia. The proposed research seeks to test the efficacy a novel CR-mimicking dietary
supplement, NR, for improving memory and cerebrovascular function in older adults with aMCI. Results from
this study will provide insight into the efficacy of a potential beneficial therapy for preventing or delaying AD.
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NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCI
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批准号:10298562
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项目类别:
-
资助金额:$5.76万
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财政年份:2017
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负责人:Christopher Martens
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依托单位:
NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCI
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批准号:9895601
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项目类别:
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资助金额:$13.31万
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财政年份:2017
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负责人:Christopher Martens
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依托单位:
NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCI
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批准号:10117160
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项目类别:
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资助金额:$13.31万
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财政年份:2017
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负责人:Christopher Martens
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依托单位:
The effects of added sugar intake on brain blood flow and hippocampal function in midlife adults
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批准号:10271700
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项目类别:
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资助金额:$34.5万
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财政年份:2016
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负责人:Christopher Martens
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依托单位:
The effects of added sugar intake on brain blood flow and hippocampal function in midlife adults
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批准号:10640265
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项目类别:
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资助金额:$33.26万
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财政年份:2016
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负责人:Christopher Martens
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依托单位:
The effects of added sugar intake on brain blood flow and hippocampal function in midlife adults
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批准号:10475090
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项目类别:
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资助金额:$34.15万
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财政年份:2016
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负责人:Christopher Martens
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依托单位:
海外基金