Systems Biology Bioinformatics Core

项目总结/摘要 生物信息学是为中心提出的整个系统生物学计划的关键要素， 转化儿科研究（CTPR），是研究项目提出的重要组成部分， COBRE项目负责人系统生物学生物信息学核心将是一个新的核心，以满足 COBRE中心的研究需求。一个由五名生物信息学家组成的小组将被召集起来， 在CTPR涵盖的所有研究领域的广泛专业知识。系统生物学生物信息学核心将 与CTPR蛋白质组学和基因组学核心密切合作，提供独一无二的系统生物学 儿科疾病研究的方法。这种协调的核心结构将使生物信息学能够 集成到一个跨学科的框架，能够支持整个范围的技术， 临床和基础研究的有效系统生物学方法所需的专业知识。密切互动 系统生物学生物信息学核心和COBRE中心项目领导人之间的合作也将导致新的 研究创新，将有利于未来的COBRE调查人员以及更广泛的校园研究 社区核心主任将提供系统生物学和生物信息学方面的机会和培训 致CTPR成员、校园和阿肯色州的研究人员。

PROJECT SUMMARY/ABSTRACT Bioinformatics is a key element of the overall systems biology program proposed for the Center for Translational Pediatric Research (CTPR) and is an essential component of the Research Projects proposed by the COBRE Project Leaders. The Systems Biology Bioinformatics Core will be a new core created to meet the research needs of the proposed COBRE Center. A team of five bioinformaticians will be assembled that have broad expertise in all research areas covered by the CTPR. The Systems Biology Bioinformatics Core will coordinate closely with the CTPR Proteomics and Genomics Cores to provide a one-of-a-kind systems biology approach for pediatric disease research. This coordinated core structure will allow bioinformatics to be integrated into a cross-disciplinary framework capable of supporting the entire range of technologies and expertise needed for an effective systems biology approach for clinical and basic research. Close interaction between the Systems Biology Bioinformatics Core and COBRE Center Project Leaders will also lead to new innovations in research that will benefit future COBRE investigators as well as the broader campus research community. Opportunities and training in systems biology bioinformatics will be provided by the Core Directors to CTPR members, the campus and researchers in Arkansas.