Pilot and feasibility study of a mobile health tool to measure respiratory distress in infants

用于测量婴儿呼吸窘迫的移动健康工具的试点和可行性研究

• 批准号: 9375142
• 负责人: Larissa Stanberry
• 金额: $ 7.5万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9375142
• 关键词: 5 year old; Abdomen; Adopted; Age-Months; Breathing; Bronchiolitis; Caring; Cause of Death; Cellular Phone; Cessation of life; Chest; Chest wall structure; Child; Child Mortality; Clinical; Clinical Data; Clinical Investigator; Computers; Data; Detection; Development; Diagnosis; Distress; Engineering; Equipment; Family; Feasibility Studies; Goals; Gold; Hospitals; Image; Infant; Lasers; Lung diseases; Measurement; Measures; Medical Device; Motion; Motivation; Movement; Nipples; Pattern; Pilot Projects; Plethysmography; Pneumonia; Positioning Attribute; Prospective Studies; Provider; Reproducibility; Research; Resources; Respiratory Failure; Respiratory distress; Robotics; Severities; Signal Transduction; System; Techniques; Technology; Time; Training; Transducers; Visual; base; computer framework; cost; experience; low and middle-income countries; mHealth; mortality; multidisciplinary; prevent; respiratory; rib bone structure; sensor; skills; tool

Project Summary Respiratory failure due to pneumonia is the leading cause of death in infants and children under 5 years of age in low and middle-income countries. These deaths could be prevented if warning signs of respiratory distress were detected early. Clinical parameters of respiratory distress in infants include increased respiratory rate (RR), marked xiphoid retractions (XR), and thoracoabdominal asynchrony (TAA). In practice, only RR is measured routinely, whereas TAA and XR are assessed subjectively from visual observation of infants' breathing. Remarkably, the only clinical tools that exist to evaluate respiratory distress are scoring systems that rely on subjective visual assessment of an infant, so the results are poorly reproducible and dependent on clinicians' training and experience. Our over-arching goal is to develop a mobile health tool to objectively measure respiratory distress in infants. Such a low-cost, accurate, easy-to-use, and readily-available tool could have a significant impact on decreasing child mortality in resource-poor settings, where respiratory diseases continue to be the main cause of death. This study will collect pilot data and validate the feasibility of measuring clinical parameters of respiratory distress (TAA, RR, and XA) from video. The novelty of the proposed study is that it will use the video capture functionality of a commodity smartphone to quantify major signs of respiratory distress objectively, noninvasively, and without the need for any specialized hardware. The accuracy of video-based parameters will be determined by comparing them with the current gold standards. The results of this study will be critical for conducting a larger prospective study on infants in distress that will provide the basis for building a mobile health tool to determine the presence and severity of respiratory distress.

项目摘要 肺炎引起的呼吸衰竭是婴儿和5岁以下儿童死亡的主要原因 在低收入和中等收入国家。如果警告呼吸窘迫的警告迹象，可以预防这些死亡 提早检测到。 婴儿呼吸窘迫的临床参数包括呼吸率提高（RR），标记为Xiphoid 回缩（XR）和胸腔异步（TAA）。实际上，只经常测量RR， 而TAA和XR是通过对婴儿呼吸的视觉观察来主观评估的。值得注意的是 只有评估呼吸窘迫的临床工具是依靠主观视觉的评分系统 对婴儿的评估，因此结果可再现不佳，并且取决于临床医生的培训和 经验。 我们的整理目标是开发一种移动健康工具，以客观地衡量婴儿的呼吸窘迫。 如此低成本，准确，易于使用且易于使用的工具可能会对 在资源贫乏的环境中，儿童死亡率降低，呼吸道疾病继续是主要原因 死亡。 这项研究将收集飞行员数据，并验证测量呼吸的临床参数的可行性 视频中的遇险（TAA，RR和XA）。拟议的研究的新颖性是它将使用视频捕获 商品智能手机的功能性以客观地量化呼吸遇险的主要迹象， 无创，无需任何专业硬件。基于视频的参数的准确性 将通过将它们与当前的黄金标准进行比较来确定。这项研究的结果至关重要 为了对遇险婴儿的婴儿进行更大的前瞻性研究，这将为建造移动设备提供基础 确定呼吸窘迫的存在和严重性的健康工具。