Analysis of age-associated changes in beta cell function and metabolism through live single-cell imaging

通过活体单细胞成像分析与年龄相关的 β 细胞功能和代谢变化

• 批准号: 9324108
• 负责人: Dudley William Lamming
• 金额: $ 19.13万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9324108
• 关键词: Adult; Age; Aging; American; Beta Cell; Bioenergetics; Biological Models; Biological Preservation; Caloric Restriction; Calories; Cell Aging; Cell physiology; Cells; Cellular Metabolic Process; Data; Defect; Development; Diabetes Mellitus; Diet; Dietary Proteins; Disease; Elderly; Electrophysiology (science); Energy Intake; Functional disorder; Genetic; Glucose; Glucose Metabolism Disorders; Goals; Gold; Health; Healthcare Systems; Human; Impairment; Individual; Insulin; Insulin Resistance; Intervention; Islets of Langerhans; Lead; Longevity; Macronutrients Nutrition; Measurement; Metabolic; Methods; Mitochondria; Morbidity - disease rate; Mus; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Pathway interactions; Play; Population; Preparation; Prevention approach; Production; Research; Resolution; Resveratrol; Risk; Risk Factors; Rodent; Role; Site; Supplementation; Testing; Work; age effect; age group; aged; blood glucose regulation; cell age; cell type; cellular imaging; diabetes risk; glycemic control; imaging modality; impaired glucose tolerance; improved; in vivo; insight; insulin secretion; islet; metabolic imaging; mitochondrial metabolism; mortality; mouse model; nonhuman primate; novel; novel strategies; optical imaging; prevent; public health relevance; response

 DESCRIPTION (provided by applicant): Advancing age is associated with an increased risk of impaired glucose tolerance and the development of type 2 diabetes. Because these disorders are themselves risk factors for diseases associated with significant morbidity and mortality, new approaches to maintain glucose homeostasis in the aged are urgently needed. Although beta cell dysfunction has been implicated as a contributing factor to disordered glucose homeostasis in the aged, the nature of the beta cell defects that emerge in older individuals has not been carefully studied. Thus, the objective of the proposed study is to identify the precise nature of the beta cell defects that emerge with age and obesity, and gain insight as to whether these defects can be mitigated by known interventions that extend healthspan.