Bioinformatics Core

生物信息学核心

• 批准号: 9233747
• 负责人: Manuel Garber
• 金额: $ 9.04万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9233747
• 关键词: Animals; Back; Bioinformatics; Collaborations; Data; Data Set; Databases; Development; Ensure; Fostering; Genes; Genome; Genomics; Genotype; Germ Cells; Grant; Imagery; Laboratories; Libraries; Maintenance; Massachusetts; Metadata; Methods; Mus; Ontology; Process; Quality Control; RNA Interference; RNA Processing; Research; Resource Informatics; Sampling; Services; Small RNA; Standardization; Transcript; Universities; Work; chromatin immunoprecipitation; computerized data processing; data acquisition; data format; data integration; data management; data visualization; differential expression; high throughput analysis; medical schools; member; piRNA; quality assurance; relational database; tool; transcriptome sequencing

Core Summary The bioinformatics core will serve as a data clearinghouse, offering standardized quality assurance, sequence data handling and visualization to all four projects of this grant. By doing so it will ensure compatible and consistent data formats, parameter optimization and centralized storage. Existing UMMS bioinformatics pipelines will be optimized to provide and standardize read alignment, alignment processing (peak calling, transcript assembly, small RNA mapping, etc., enrichment analysis (Gene Ontology enrichments, etc.), and dataset integration (e.g. differential expression of piRNAs in different conditions). The centralized storage, processing and analysis of project data will thus significantly enhance integration between all four project components. Relevance The services provided by the Bioinformatics Core (Core C) are essential to research proposed by all four Projects. The core will provide storage, quality control, and preliminary analysis of high-throughput data from the three experimental projects (I-III), and make this data available to the computational project for in depth study (Project IV).

核心摘要