Race/Ethnicity and Mammographic Density: Genetic and Lifestyle Factors

种族/民族和乳房X光密度：遗传和生活方式因素

• 批准号: 9318476
• 负责人: Erica T Warner
• 金额: $ 12.95万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-07 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9318476
• 关键词: Adolescent; Adult; Affect; Age; Age at Menarche; Architecture; Area; Award; Biological Markers; Body Size; Body fat; Body mass index; Boston; Breast; Breast Cancer Risk Factor; Childhood; Cohort Studies; Collection; Computer software; DNA; Data; Development; Enrollment; Estrogen Antagonists; Ethnic Origin; Ethnic group; European; Exposure to; First Births; Future; Genes; Genetic; Genetic Markers; Genetic Risk; Genotype; Goals; Hispanics; Hospitals; Incidence; K-Series Research Career Programs; Life; Mammographic Density; Mammography; Measurement; Measures; Menopausal Status; Mentors; Mexican; Modification; Molecular Epidemiology; Not Hispanic or Latino; Patients; Pattern; Population; Population Density; Population Genetics; Postmenopause; Premenopause; Questionnaires; Race; Research; Research Personnel; Risk; Risk Marker; Saliva; Scientist; Single Nucleotide Polymorphism; Smoking; Statistical Methods; Surrogate Endpoint; Surrogate Markers; Time; Tissues; Training; Update; Woman; cancer biomarkers; cancer health disparity; cancer risk; cohort; density; digital; early life exposure; ethnic difference; follow-up; genetic epidemiology; genetic risk factor; genome wide association study; insight; lifestyle factors; malignant breast neoplasm; mortality; novel; programs; public health relevance; racial and ethnic; racial and ethnic disparities; risk variant; skill acquisition; study population

DESCRIPTION (provided by applicant): The primary goal of this mentored career development award is to provide the candidate with training and skills development needed to transition to an independent investigator. Mentored training will be obtained in the following areas: 1) surrogate and intermediate markers of cancer risk; 2) molecular and genetic epidemiology and statistical methods for population genetics; 3) biospecimen collection and use. The anticipated result of this mentored training and research program is the submission of an R01 application in year four of the award period. Mammographic density (MD) is a strong risk factor for breast cancer, yet it remains unclear the extent to which it differs between black, Hispanic and white women, how density changes over time and whether this trajectory differs by race/ethnicity, and what genes contribute to mammographic density in black and Hispanic women. We propose to examine the racial/ethnic patterns of mammographic density and change in density, explore early-life and adult predictors of MD and change in density, and investigate whether SNPs associated with percent density in white women are similarly associated among black and Hispanic women. Our study population is the Boston Mammography Cohort Study (BMCS). BMCS is a study of mammographic density among women obtaining mammograms at Brigham and Women's Hospital (BWH) in Boston, MA. Over 2500 women have been enrolled since 2007 and enrollment is ongoing. We anticipate that an additional ~500 women will be enrolled prior to the start of the study period. Women completed a questionnaire on breast cancer risk factors at enrollment and as a part of this study we will request that they complete a follow-up questionnaire to update their exposures. For each woman, we have collected, or will collect, all digital mammograms received as a patient at BWH. MD is assessed using VolparaTM software that calculates automated volumetric measures of percent density, absolute dense volume and absolute non-dense volume. We will attempt to collect saliva from all self-identified black (n=295) and Hispanic (n=340) women in the cohort. DNA extracted from collected saliva will be genotyped. We expect that the proposed area of research will provide: important insight into racial patterns of mammographic density, novel information about changes in density over time across racial/ethnic groups, and multiethnic data on novel measures of MD, and targets for future fine mapping of MD risk alleles in black and Hispanic women.

描述(由申请者提供)：这个辅导式职业发展奖的主要目标是为候选人提供过渡到独立调查人员所需的培训和技能发展。将在以下领域获得指导培训：1)癌症风险的替代和中间标记；2)分子和遗传流行病学以及群体遗传学的统计方法；3)生物样本的收集和使用。这一指导培训和研究计划的预期结果是在获奖期的第四年提交一份R01申请。乳房X光检查密度(MD)是乳腺癌的一个重要风险因素，但目前尚不清楚黑人、西班牙裔和白人女性的乳房X光检查密度差异有多大，密度如何随时间变化，这一轨迹是否因种族/民族而不同，以及黑人和西班牙裔女性的乳房X光检查密度有哪些基因影响。我们建议研究乳房X光检查密度和密度变化的种族/民族模式，探索早期和成人预测MD和密度变化的因素，并调查白人女性中与百分比密度相关的SNPs是否与黑人和西班牙裔女性相似。我们的研究人群是波士顿乳房摄影队列研究(BMCS)。BMCS是对在马萨诸塞州波士顿的布里格姆妇女医院(BWH)进行乳房X光检查的女性的乳房X光密度的研究。自2007年以来，已有2500多名妇女注册，注册工作正在进行中。我们预计，在研究开始之前，还将有大约500名妇女参加。女性在登记时完成了一份关于乳腺癌危险因素的问卷，作为这项研究的一部分，我们将要求她们完成一份后续问卷，以更新她们的暴露情况。对于每一位女性，我们已经收集或将收集作为BWH患者收到的所有数字乳房X光照片。使用VolparTM软件评估MD，该软件计算百分比密度、绝对密度体积和绝对非密度体积的自动体积测量。我们将尝试收集队列中所有自我认同的黑人(n=295)和西班牙裔(n=340)女性的唾液。从采集的唾液中提取的DNA将进行基因分型。我们期望拟议的研究领域将提供：对乳房X光检查密度的种族模式的重要洞察，关于不同种族/民族群体密度随时间变化的新信息，以及关于MD新测量的多民族数据，以及未来在黑人和西班牙裔妇女中精细绘制MD风险等位基因的目标。

项目成果

Evaluation of existing patient educational materials and development of a brochure for women with dense breasts.

评估现有患者教育材料并为致密乳房女性制作手册。

• DOI: 10.1016/j.breast.2020.02.001
• 发表时间: 2020
• 期刊: Breast (Edinburgh, Scotland)
• 作者: Warner,EricaT;Kennedy,Mark;Maschke,Ariel;Hopkins,MargaretF;Wernli,Karen;Gunn,ChristineM
• 通讯作者: Gunn,ChristineM