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Using mixed metal clusters in the reductive synthesis of doped ZnO nanocrystals

使用混合金属簇还原合成掺杂 ZnO 纳米晶

基本信息

批准号：
9388897
负责人：
Emily Tsui
金额：
$ 0.04万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-21 至 2017-05-20
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9388897
关键词：
Acids Address Adsorption Affect Anions Behavior Biological Biological Assay Biosensing Techniques Biotechnology Blinking Cations Chemicals Complex Crystallization Detection Development Diagnosis Diagnostic Disease Effectiveness Elements Environment Event Fluorescence Foundations Goals Growth Health Care Costs Image In Situ Investigation Ions Lanthanoid Series Elements Ligands Light Location Magnetism Malignant Neoplasms Metals Methodology Methods Molecular Morphology Nanostructures Optics Preparation Property Public Health Quantum Dots Research Research Proposals Route Salts Semiconductors Site Solvents Source Statistical Distributions Structure Surface Techniques Technology Temperature Testing Therapeutic Universities Washington Work Zinc Zinc Cluster Zinc Oxide absorption base bioimaging carboxylate density design electric field fluorescence imaging human disease improved luminescence magnetic field metal complex nanocrystal nanoscale novel novel strategies physical property pressure public health relevance segregation small molecule spectroscopic survey tool

项目摘要

DESCRIPTION (provided by applicant): The development of new tools for early disease detection and diagnosis is essential to improving public health and lowering healthcare costs. Semiconductor nanocrystals, also known as quantum dots, display optical properties that give them enormous potential in the fields of fluorescence imaging, biosensing, and diagnostics. To advance the effectiveness of nanocrystals in these applications, however, the range of their physical properties must be broadened to include: 1) tuning of fluorescence emission and increased lifetimes 2) sensitivity to electric or magnetic fields and 3) suppression of blinking. One current approach has been the incorporation of metal impurities in the crystal lattice, or doping. Doped nanocrystals comprise a relatively unexplored field, although in recent years nanocrystals with Mn2+, Cu2+, and lanthanide dopants have been studied for their unique optical and magnetic properties. Controlling the amount and location of dopant incorporation within the nanocrystal is important for controlling these new physical properties. Unfortunately, this level o synthetic control has been challenging to achieve, and the mechanisms of dopant incorporation in nanocrystals are still not completely understood. The overall objective of the proposed research is to develop new synthetic methods for doped zinc oxide (ZnO) nanocrystals with improved control over dopant density and distribution. Specifically, this proposal describes the design and synthesis of mixed metal carboxylate-supported multinuclear zinc clusters with coordinated oxometallate ligands as soluble single-source precursors of doped ZnO nanocrystals. The synthesis of these clusters affords the opportunity to study solution-state cluster degradation and aggregation of multinuclear zinc complexes that may serve as intermediates for nucleation clusters. A second aspect of this research plan is to develop a novel approach for the synthesis of doped nanocrystals based upon in situ reduction of oxometallate anions during ZnO lattice growth. With this approach, different nucleation and growth dynamics will be observed that may afford novel and spectroscopically unique nanostructures. These results will allow the design of different types of doped nanocrystals that target specific optical and magnetic properties. The broad, long-term goal of the proposed project is to provide access to these materials to expand the chemical toolkit available for biomedical applications.

描述（由申请人提供）：开发用于早期疾病检测和诊断的新工具对于改善公共卫生和降低医疗成本至关重要。半导体纳米晶体，也称为量子点，显示出的光学特性使其在荧光成像、生物传感和诊断领域具有巨大的潜力。然而，为了提高纳米晶体在这些应用中的有效性，必须扩大其物理特性的范围，包括：1）荧光发射的调节和延长的寿命2）对电场或磁场的敏感性以及3）抑制眨眼。目前的一种方法是在晶格中掺入金属杂质或掺杂。掺杂纳米晶体是一个相对未开发的领域，尽管近年来人们已经研究了具有 Mn2+、Cu2+ 和镧系元素掺杂剂的纳米晶体，因为它们具有独特的光学和磁性能。控制纳米晶体内掺杂剂掺入的量和位置对于控制这些新的物理性质非常重要。不幸的是，这种合成控制水平很难实现，并且纳米晶体中掺杂剂掺入的机制仍未完全了解。该研究的总体目标是开发掺杂氧化锌（ZnO）纳米晶体的新合成方法，并改进对掺杂剂密度和分布的控制。具体来说，该提案描述了混合金属羧酸盐支撑的多核锌簇的设计和合成，其具有配位的金属氧酸盐配体作为掺杂ZnO纳米晶体的可溶性单源前体。这些簇的合成提供了研究溶液态簇降解和多核锌配合物聚集的机会，多核锌配合物可以作为成核簇的中间体。该研究计划的第二个方面是开发一种基于 ZnO 晶格生长过程中金属氧酸根阴离子原位还原的掺杂纳米晶体合成新方法。通过这种方法，将观察到不同的成核和生长动力学，这可能提供新颖且光谱上独特的纳米结构。这些结果将允许设计针对特定光学和磁性特性的不同类型的掺杂纳米晶体。该项目的广泛、长期目标是提供这些材料，以扩展可用于生物医学应用的化学工具包。