Mobile cognitive control training for the treatment of Alcohol Use Disorder and Post Traumatic Stress Disorder

用于治疗酒精使用障碍和创伤后应激障碍的移动认知控制训练

• 批准号: 9409534
• 负责人: Hyun Kyu Lee
• 金额: $ 22.47万
• 依托单位: POSIT SCIENCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9409534
• 关键词: Activities of Daily Living; Address; Alcohol consumption; Alcohols; Area; Attention; Chronic; Clinic; Clinical; Cognitive; Cognitive deficits; Collaborations; Complex; Computer Systems; Computer software; Cues; Data; Development; Disease; Economic Burden; Ensure; Exercise; Feasibility Studies; Feedback; Focus Groups; General Population; Goals; Healthcare Systems; Home environment; Impairment; Impulsivity; Individual; Informal Social Control; Instruction; Intervention; Measures; Mediating; Memory; Methods; Modeling; Monitor; Neurocognitive; Neuropsychological Tests; Outcome; Outcome Measure; Patient Self-Report; Patients; Performance; Phase; Pilot Projects; Play; Population; Post-Traumatic Stress Disorders; Problem Solving; Process; Program Acceptability; Psyche structure; Psychiatric Diagnosis; Psychopathology; Quality of life; Questionnaires; Readiness; Recovery; Research; Research Personnel; Rewards; Role; Schedule; Science; Scientist; Self Management; Short-Term Memory; Software Design; Stigmatization; Stimulus; Substance Use Disorder; Symptoms; Target Populations; Training; Training Programs; Treatment outcome; alcohol abuse therapy; alcohol comorbidity; alcohol monitoring; alcohol seeking behavior; alcohol use disorder; alternative treatment; attentional bias; base; brain health; cloud based; cognitive ability; cognitive control; cognitive enhancement; cognitive function; cognitive system; cognitive training; compliance behavior; cost; design; efficacy trial; evidence base; executive function; experience; flexibility; functional outcomes; improved; indexing; innovation; mobile application; novel; novel therapeutics; phase 2 study; phase II trial; programs; remediation; restoration; skills; social; social stigma; software development; stress disorder; tool; treatment program; usability; web site

Project Summary Abstract The primary objective of the current project is to develop and evaluate the feasibility of mobile cognitive- control training program for the treatment of those who are suffering from co-morbid Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD). Unlike previous AUD interventions that may overlook the role of co-occurring psychopathology, those that target “trans-disease” cognitive deficits for remediation represent an innovative, evidence-based, and potentially high-yield approach for optimizing recovery outcomes and reducing chronic impairment among vulnerable individuals with co-occurring AUD and PTSD. This novel therapeutic strategy is designed to (1) broadly assess cognitive and functional abilities, then (2) train cognitive abilities with the specific goal of strengthening cognitive systems that mediate core deficits in AUD and PTSD, and (3) continuously inform clinicians about patient compliance and treatment progress via a Cloud-based patient-to-clinic portal. Also, brief self-report of daily alcohol use and PTSD status shall provide data useful for both evaluating real-world outcomes and product model acceptability. In the first specific aim, we will define a set of enhancements to make the user experience and the game play sufficient to motivate the continued use of the program. We will then employ established methods of software design and development and iteratively refine the implemented design to complete the development of the enhanced program for a feasibility trial (specific aim 2) conducted locally, in collaboration with the research team at the Palo Alto VA Health Care System. Given the ease of access of mobile-based training and online monitoring of AUD-PTSD status, this project should result in the development of a new, powerful tool to provide effective adjunctive therapy that results in far greater treatment outcome among individuals with co-occurring AUD and PTSD.

项目摘要 本项目的主要目标是开发和评估移动的认知- 为治疗患有酒精使用障碍共病的人而制定的控制培训计划 (AUD)和创伤后应激障碍（PTSD）。与之前的澳元干预不同， 共同发生的精神病理学的作用，那些针对“跨疾病”认知缺陷的补救措施 代表了一种创新的、以证据为基础的、潜在的高产方法，用于优化恢复结果 减少合并AUD和PTSD的脆弱个体的慢性损伤。这本小说 治疗策略旨在（1）广泛评估认知和功能能力，然后（2）训练认知能力， 能力，具体目标是加强介导AUD和PTSD核心缺陷的认知系统， 以及（3）通过基于云的 病人到诊所的门户。此外，每日饮酒和PTSD状态的简短自我报告应提供有用的数据， 评估真实世界的结果和产品模型的可接受性。在第一个具体目标中，我们将定义一个 一组增强功能，使用户体验和游戏玩法足以激励继续使用 程序的一部分。然后，我们将采用已建立的软件设计和开发方法， 完善已实施的设计，以完成可行性试验的改进方案的开发 （具体目标2）与帕洛阿尔托弗吉尼亚州卫生保健研究小组合作，在当地进行 系统考虑到基于移动的培训和AUD-PTSD状态的在线监测的方便性， 该项目应导致开发一种新的，强大的工具，以提供有效的连续治疗， 在合并有AUD和PTSD的个体中，治疗效果更好。