Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

基于可塑性的自适应认知疗法治疗阿尔茨海默病

• 批准号: 8715467
• 负责人: Hyun Kyu Lee
• 金额: $ 22.15万
• 依托单位: BRAIN PLASTICITY, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8715467
• 关键词: Adult; Age-associated memory impairment; Aging; Alzheimer disease prevention; Alzheimer' s Disease; American; Americas; Area; Brain; Characteristics; Cognition; Cognitive; Cognitive remediation; Collaborations; Complex; Computer software; Computers; Data; Data Set; Development; Diet; Elderly; Enrollment; Ensure; Evaluation; Exercise; Feasibility Studies; Feedback; Focus Groups; Generations; Goals; Health; Health Status; Hour; Impaired cognition; Individual; Individual Differences; Internet; Investigation; Iowa; Life Style; Link; Measures; Methods; Modeling; Moods; Neurologic; Neuronal Plasticity; Onset of illness; Outcome; Outcome Measure; Participant; Pathology; Patient Self-Report; Performance; Phase; Phase II Clinical Trials; Play; Population; Prevention; Process; Program Acceptability; Quality of life; Questionnaires; Randomized Controlled Trials; Readiness; Reporting; Research; Rest; Risk; Scientist; Secure; Self Efficacy; Series; Sleep; Software Design; Support System; System; Target Populations; Training; Training Programs; Universities; aged; arm; artist; base; cognitive control; cognitive function; cognitive training; cohort; computerized; design; efficacy trial; experience; feeding; field study; functional restoration; high risk; improved; indexing; information processing; normal aging; novel; novel therapeutics; open label; operation; phase 2 study; prevent; programs; public health relevance; resilience; skills training; social; software development; tool; training project; willingness

DESCRIPTION (provided by applicant): The primary objective of the current project is to develop and evaluate the efficacy of on-line brain plasticity-based computerized assessment tool and training program for the prevention and delay of the onset of Alzheimer's disease (AD). This novel therapeutic strategy is designed to re-connect and reinvigorate Default Network (DN) brain areas by 1) increasing feed-forward power in brain systems in ways that are designed to reactivate them, and by 2) directly exercising highest-level neurological (DN) processes. Computerized assessments will be embedded in the exercise suite to further document the status of 1) DN levels of operation in the brain, 2) the complex systems that support them, and 3) important near- and far-transfer targets for training. Also, brief self-report of lifestyle stats and change provided via weekly self-rated evaluations related to health status, physical exercise, social activities, diet, sleep, mood, and self-efficacy shall provide data useful both fo evaluating real-world outcomes and product model acceptability. In the first specific aim, we will organize a series of small focus groups composed of normally aged adults to discuss and play various computer games and cognitive training programs. Based on questionnaires from and discussions with these focus groups, we will define a set of enhancements to make the user experience and the game play sufficient to motivate the forty hours of program. We will then employ established methods of software design and development and iteratively refine the implemented design to complete the development of the enhanced program for a feasibility trial conducted locally, in collaboration with the research team at the University of Iowa. Given the ease of access of online-based assessment and training, this project should result in the development of a new, powerful tool to assess and prevent the risk of onset of AD, and to provide effective adjunctive therapy those results in far greater resilience against cognitive impairment in a substantially greater pre-AD population.

项目描述（申请人提供）：本项目的主要目的是开发和评估基于脑可塑性的在线计算机化评估工具和培训程序对预防和延迟阿尔茨海默病（AD）发作的有效性。这种新的治疗策略旨在通过以下方式重新连接和重振默认网络（DN）大脑区域：1）以旨在重新激活它们的方式增加大脑系统中的前馈功率，以及2）直接行使最高级别的神经（DN）过程。计算机化评估将嵌入到练习套件中，以进一步记录1）大脑中DN操作水平的状态，2）支持它们的复杂系统，以及3）重要的近距离和远距离转移目标。此外，通过与健康状况、体育锻炼、社会活动、饮食、睡眠、情绪和自我效能相关的每周自我评价提供的生活方式统计和变化的简要自我报告应提供对评价现实世界结局和产品模型可接受性有用的数据。在第一个具体目标中，我们将组织一系列由正常年龄的成年人组成的小型焦点小组，讨论和玩各种电脑游戏和认知训练计划。根据这些焦点小组的问卷调查和讨论，我们将定义一组增强功能，以使用户体验和游戏玩法足以激励40小时的计划。然后，我们将采用已建立的软件设计和开发方法，并与爱荷华州大学的研究团队合作，反复完善已实施的设计，以完成本地可行性试验的增强程序的开发。鉴于在线评估和培训的便利性，该项目应导致开发一种新的，强大的工具来评估和预防AD发作的风险，并提供有效的预防性治疗，从而在更大的AD前人群中对认知障碍产生更大的恢复力。