Delivering instructional microstimulation in frontal and parietal cortical areas
在额叶和顶叶皮质区域提供指导性微刺激
基本信息
- 批准号:9302328
- 负责人:
- 金额:$ 5.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-01 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAnteriorApraxiasAreaBehavioralBody partBrainBypassClinicalCognitiveDataDorsalEsthesiaImpairmentIndividualInstructionJoystickLawsLearningLocationMediatingMethodsMonkeysMotorMotor CortexMovementNervous System TraumaNervous system structureNeural PathwaysParietalParietal LobeRehabilitation therapyRoleSomatosensory CortexStructureTechniquesTechnologyTestingTherapeuticVisualWorkbasefunctional restorationgraspindividual patientmicrostimulationmotor disordermotor impairmentnervous system disorderneural circuitneural modelneuroprosthesisnovelrelating to nervous systemresponserestorationsuccessvisual informationvisual motor
项目摘要
Abstract: For individuals with apraxia, damage to cortical areas involved in prehension, or the connections
between these areas, results in an inability to perform a specific action associated with a particular object or
instruction. Neuroprosthetic technology could bypass the damaged neural connections by delivering artificial
instructions to specific cortical areas. One method of delivering artificial instructions is intracortical
microstimulation (ICMS). Previous studies have demonstrated ICMS in primary somatosensory cortex can
deliver instructions about how to perform behavioral tasks. Stimulating primary somatosensory cortex elicits
sensations at different parts of the body. These different sensations are then associated with specific motor
responses in order to perform the task. The proposed studies will examine the ability to use ICMS to deliver
instructions in cortical areas associated with prehension. Prehension is the act of reaching and grasping,
elaborated through two parallel neural pathways whereby visual information propagates from parietal cortex to
motor cortex by way of premotor cortex. To our knowledge, no one has studied how ICMS could deliver
instructions in other cortical areas. It is important to understand if other cortical areas can be instructed with
ICMS equally well in order to develop methods for restoring damaged cortico-cortical connections. Preliminary
data from this application suggest ICMS instructions can be successfully delivered to ventral premotor cortex,
an area involved in planning grasps. Based on these successful preliminary results, other frontal and parietal
areas involved in prehension will be tested to determine how well ICMS instructions can be delivered.
Understanding which cortical areas can most readily be stimulated to deliver instructions, and how the
underlying cortico-cortical connectivity affects the neural processing of these artificial instructions, will enable
neuroprosthetic technology to bypass damaged cortico-cortical connections and become a clinically viable
method for restoring lost cognitive motor function.
翻译后摘要:对于失用症的个人,损害涉及的大脑皮层区域,或连接
在这些区域之间,导致无法执行与特定对象相关的特定动作,或
指导。神经修复技术可以通过人工神经连接绕过受损的神经连接,
特定皮层区域的指令。传递人工指令的一种方法是皮层内的
微刺激(ICMS)。先前的研究表明,初级躯体感觉皮层的ICMS可以
提供关于如何执行行为任务的指导。刺激初级躯体感觉皮层
身体不同部位的感觉。这些不同的感觉与特定的运动有关。
响应,以执行任务。拟议的研究将审查使用ICMS提供
大脑皮层区域的指令。执着是一种伸手去拿的行为,
通过两条平行的神经通路,视觉信息从顶叶皮层传播到
运动前皮层的运动皮层。据我们所知,还没有人研究过ICMS如何提供
其他皮层区域的指令。重要的是要了解其他皮层区域是否可以指示与
ICMS同样很好,以开发恢复受损皮质-皮质连接的方法。初步
来自该应用的数据表明ICMS指令可以成功地传递到腹侧前运动皮层,
一个涉及规划的领域。基于这些成功的初步结果,其他额叶和顶叶
将测试涉及到的领域,以确定如何以及ICMS指令可以交付。
了解哪些皮层区域最容易被刺激来传递指令,以及
潜在的皮质-皮质连接会影响这些人工指令的神经处理,
神经假体技术绕过受损的皮质-皮质连接,成为临床上可行的
用于恢复丧失的认知运动功能的方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kevin Andrew Mazurek其他文献
Kevin Andrew Mazurek的其他文献
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{{ truncateString('Kevin Andrew Mazurek', 18)}}的其他基金
Delivering instructional microstimulation in frontal and parietal cortical areas
在额叶和顶叶皮质区域提供指导性微刺激
- 批准号:
9190587 - 财政年份:2016
- 资助金额:
$ 5.95万 - 项目类别:
A Neural Prosthesis for the Restoration of Locomotion after Spinal Cord Injury
用于恢复脊髓损伤后运动的神经假体
- 批准号:
8538836 - 财政年份:2012
- 资助金额:
$ 5.95万 - 项目类别:
A Neural Prosthesis for the Restoration of Locomotion after Spinal Cord Injury
用于恢复脊髓损伤后运动的神经假体
- 批准号:
8398291 - 财政年份:2012
- 资助金额:
$ 5.95万 - 项目类别:
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