RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULE

摘要 分子信息学模块 分子信息学模块将提供蛋白质组学和基因组学研究 战略和技术，以参与这项P30核心赠款的研究人员， 视觉研究。培养蛋白质组学和基因组学专业知识所需的时间 技术往往会给有能力的调查人员和其他研究人员造成研究障碍。 专业技能。具体而言，该模块将提供实验设计咨询， 为正常人的整体和靶向蛋白质定量提供技术支持和数据分析 和患病的眼部组织/细胞系统;为蛋白质组学提供集中的资源 蛋白质视觉科学研究的研究策略及技术支援 鉴定、蛋白质-蛋白质相互作用和翻译后修饰;提供 实验设计咨询和技术支持，为正常和 患病的眼部组织和细胞系统;并为以下方面提供集中资源： 基因组研究战略和视觉科学研究的技术支持， 基因分型、基因突变/多态性分析和多标记酶标仪 分析（细胞分析、免疫分析、动力学和结合分析、药物筛选）。 访问此核心模块将支持NEI R 01资助的研究人员， 招募的研究人员获得NEI R 01赠款提交的数据，促进合作 RO 1资助的调查员和新招聘的调查员之间的互动， 其他部门的研究人员对视觉系统的研究，并成为一个有价值的 部门资源，吸引更多的视觉科学家到我们的计划，因为我们 扩大我们的研究人员。

Abstract Molecular Informatics Module The Molecular Informatics Module will provide proteomic and genomic research strategies and technologies to the investigators involved in this P30 Core Grant for Vision Research. The time required to develop expertise in proteomic and genomic technologies often generates research roadblocks to capable investigators with other specialized skills. Specifically the module will provide experimental design consultation, technical support and data analysis for global and targeted protein quantitation in normal and diseased ocular tissues/cell systems; provide a centralized resource for proteomic research strategy and technical support for vision science studies involving protein identification, protein-protein interactions and posttranslational modifications; provide experimental design consultation and technical support for gene profiling in normal and diseased ocular tissues and cell systems; and provide a centralized resource for genomic research strategy and technical support for vision science studies requiring genotyping, genetic mutation/polymorphism analyses, and multi-label plate reader assays (cellular assays, immunoassays, kinetic and binding assays, drug screens). Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.