Gonococcal Vaccine Evaluation in a Humanized Mouse Model
人源化小鼠模型中的淋球菌疫苗评估
基本信息
- 批准号:9389653
- 负责人:
- 金额:$ 72.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-17 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAnimal ModelAntibiotic ResistanceAntibioticsAntigensBacterial AdhesinsBacterial InfectionsBiologicalCEACAM1CEACAM5 geneCeftriaxoneCell modelCervicalDataDefectDevelopmentDiestrusDiseaseEctopic PregnancyEpitheliumEstradiolEstrusEthicsEventExposure toFemaleFibrosisFutureGenesGeneticGenitourinary systemGoalsGonorrheaGrantGray unit of radiation doseHIVHumanImmuneImmune responseImmunityImmunological ModelsIncidenceInfectionInfertilityInflammationInflammatory ResponseInvestigationLaboratoriesLifeModelingMolecular ModelsMusNatural ImmunityNeisseria gonorrhoeaeNeisseria meningitidisPan GenusPatternPelvic Inflammatory DiseasePhasePredispositionPublic HealthPublishingQuinolonesReceptor CellResearchRoleSisterSolidSpecificitySymbiosisTimeTransgenic MiceTubeVDAC1 geneVaccinationVaccine DesignVaccinesVaginaVirulence FactorsVirus SheddingWorkacquired immunitycytokinefitnessgonococcal porinhuman datahumanized mousein vivoinsightmicrobialmolecular modelingmouse modelneutrophilnonhuman primatepathogenreproductivereproductive tractresponsesuccesstooltranscriptome sequencingtranscriptomicstransmission processvaccine candidatevaccine developmentvaccine evaluation
项目摘要
PROJECT SUMMARY
Efforts to develop a gonococcal vaccine have continued for over three decades without notable progress.
While the significant sequelae of infection in females and solid evidence that concurrent gonococcal (GC)
infection can enhance HIV transmission have spurred these investigations, this goal has become more urgent
given the recent increase in GC antibiotic resistance, especially to ceftriaxone. Two major issues associated
with this absence of success have been 1) the lack of an animal model that appreciates the human specificity
of gonococcal adhesins and other virulence factors, and 2) the lack of correlates of immunity that can inform
vaccine design. The overall objective of this proposal is to evaluate potential gonococcal vaccine candidates in
a recently developed GC both transcervical induced upper genital tract (UGT) and intravaginal induced lower
genital tract (LGT) infection models utilizing humanized transgenic mice expressing CEACAM 1 or CEACAM5
respectively. The aims of this grant are to 1) Evaluate the ability of high priority gonococcal vaccine candidates
(porin, OMV and LOS derived mimotopes) to protect humanized TG mice from LGT or UGT GC infection, 2)
Determine which immune defects may allow for enhanced infection in WT mice (to aid in discerning potential
correlates of immunity) and 3) Examine pattern of in vivo expressed GC genes by RNAseq transcriptomics and
Compare to similar data from humans. If the aims are fulfilled, a new model for gonococcal vaccine evaluation
will be established and validated by comparison to human infection, correlates of gonococcal immunity will be
discerned, and the relative utility of gonococcal vaccine candidates will be determined in order to prioritize and
guide their future development towards their ultimate use in humans.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LEE Mark WETZLER其他文献
LEE Mark WETZLER的其他文献
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{{ truncateString('LEE Mark WETZLER', 18)}}的其他基金
Gonococcal Vaccine Evaluation in a Humanized Mouse Model
人源化小鼠模型中的淋球菌疫苗评估
- 批准号:
8584887 - 财政年份:2013
- 资助金额:
$ 72.82万 - 项目类别:
Gonococcal Vaccine Evaluation in a Humanized Mouse Model
人源化小鼠模型中的淋球菌疫苗评估
- 批准号:
8868920 - 财政年份:2013
- 资助金额:
$ 72.82万 - 项目类别:
Gonococcal Vaccine Evaluation in a Humanized Mouse Model
人源化小鼠模型中的淋球菌疫苗评估
- 批准号:
8702079 - 财政年份:2013
- 资助金额:
$ 72.82万 - 项目类别:
Boston University Inflammatory Disorders Training Grant
波士顿大学炎症性疾病培训补助金
- 批准号:
8860100 - 财政年份:2011
- 资助金额:
$ 72.82万 - 项目类别:
Effect of Neisserial Porin in Immune Cell Apoptosis
奈瑟氏球菌孔蛋白对免疫细胞凋亡的影响
- 批准号:
6758513 - 财政年份:2002
- 资助金额:
$ 72.82万 - 项目类别:
Effect of Neisserial Porin in Immune Cell Apoptosis
奈瑟氏球菌孔蛋白对免疫细胞凋亡的影响
- 批准号:
6913540 - 财政年份:2002
- 资助金额:
$ 72.82万 - 项目类别:
Effect of Neisserial Porin in Immune Cell Apoptosis
奈瑟氏球菌孔蛋白对免疫细胞凋亡的影响
- 批准号:
6544274 - 财政年份:2002
- 资助金额:
$ 72.82万 - 项目类别:
Effect of Neisserial Porin in Immune Cell Apoptosis
奈瑟氏球菌孔蛋白对免疫细胞凋亡的影响
- 批准号:
6645684 - 财政年份:2002
- 资助金额:
$ 72.82万 - 项目类别:
Effect of Neisserial Porin in Immune Cell Apoptosis
奈瑟氏球菌孔蛋白对免疫细胞凋亡的影响
- 批准号:
7080405 - 财政年份:2002
- 资助金额:
$ 72.82万 - 项目类别:
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