A real-time, cost-effective, accurate UV measurement and sun protection system to prevent and reduce the incidence of sunburn in high-risk consumers.

项目总结/摘要 美国外科医生报告说，皮肤癌是美国最常见的癌症类型。的数量 据估计，在过去30年中的某个时候患皮肤癌的美国人超过了所有其他人。 癌症综合每年有超过75，000例新的黑色素瘤病例， 一万人死亡报告表明，近90%的皮肤癌是由紫外线照射引起的，尽管如此 许多美国人继续遭受有害水平的紫外线，部分原因是它是负担 来准确评估一个人的紫外线剂量此外，晒伤甚至黑色素瘤的经历往往不会 提供足够的动力来改变太阳的行为。可穿戴紫外线监测器提供了潜在的补救措施，但现有的 这些装置昂贵、突兀，并且常常与水上娱乐不相容。它们的内在运作模式 由于间歇性测量和推断剂量的插值算法而导致不准确。这些 缺点导致不采用、不当使用或停用，限制了它们防止过度使用的能力， 晒伤和皮肤癌。一个关键的未满足的需求是低成本、不显眼的防晒系统， 将精确的剂量测定与能够影响健康行为的用户响应式软件界面相结合。 拟议的工作解决了需要一个突破性的传感器技术和创新的用户 界面，使知情的防晒行为。传感器是豌豆大小的无电池“贴纸”， 从根本上区分使用模式、成本结构和准确性。不间断电荷积累 提供连续的UV-A和UV-B测量能力，比任何替代方案都具有更高的准确性。的 其结果是个人剂量计具有非常小的干扰性和相应的小成本， “赠品”分销策略。由用户特定暴露触发的实时消息将促进健康 一般人群和高危人群的阳光行为，包括那些药物诱导的光， 增加对太阳敏感性的疾病。 第一阶段的活动将通过系统地比较传感器（非传感器）， 可穿戴）实验室仪器，并生成具有基于UV的双向通信的移动的应用程序 特定于用户皮肤类型的公差。焦点小组将评估系统的可用性及其可能性 来影响防晒行为。第二阶段的活动将优化设计，以降低成本，提高可靠性 条件下，目标是每台设备<2美元，在水上运动和大量出汗期间/之后运行可靠。 这些任务的成功完成将有助于在前瞻性队列研究中评估该技术， 18-49岁的黑色素瘤幸存者的高风险人群。100人的扩展（90天）行为研究 将确定合规性（目标>85%）和用户满意度（目标>70%），以确认广泛的可接受性， 影响健康阳光行为的功效。

PROJECT SUMMARY/ABSTRACT The US Surgeon General reports that skin cancer is the most common type of cancer in the US. The number of Americans who have had skin cancer at some point over the last three decades is estimated to exceed all other cancers combined. There are more than 75,000 new cases of melanoma each year, resulting in more than 10,000 deaths. Reports indicate that nearly 90% of skin cancers are caused by UV exposure, and despite the risks many Americans continue to subject themselves to harmful levels of UV partly because it is burdensome to accurately assess one's UV dose. Furthermore, the experience of sunburn or even melanoma often do not provide sufficient motivation to change sun behavior. Wearable UV monitors offer potential remedy, but existing devices are expensive, obtrusive, and often incompatible with water recreation. Their intrinsic operational mode has inaccuracy derived from intermittent measurements and interpolative algorithms to infer dose. These shortcomings cause non-adoption, improper use or discontinuation, limiting their ability to prevent overexposure, sunburn, and skin cancer. A critical unmet need is for a low cost, unobtrusive sun protection system that combines accurate dosimetry with user-responsive software interfaces capable of influencing healthy behavior. The proposed work addresses the need with a breakthrough sensor technology and an innovative user interface that enables informed sun-protection behavior. The sensors are pea-sized battery-free “stickers” with fundamentally differentiated modes of use, cost structures, and accuracy. Uninterrupted charge accumulation imparts continuous UV-A and UV-B measurement capability with greater accuracy than any alternative. The result is a personal dosimeter with vanishingly small obtrusiveness and correspondingly small cost, allowing “giveaway” distribution strategies. Real-time messages triggered by user-specific exposure will promote healthy sun behavior in the general population and at-risk segments, including those with medicine-induced photo- sensitivities or diseases that increase sensitivity to the sun. Activities in Phase I will establish the accuracy of the sensors through systematic comparisons to (non- wearable) laboratory instrumentation and produce a mobile app with bi-directional communications based on UV tolerances specific to the user's skin type. Focus groups will assess the usability of the system and its likelihood to influence sun-protection behavior. Phase 2 activities will optimize designs for cost and reliability in real-world conditions, with targets of <$2 per device and robust operation during/after watersports and heavy sweating. Successful completion of these tasks will enable assessment of the technology in prospective cohort studies in high-risk populations of melanoma survivors aged 18-49. Extended (90 day) behavior studies of 100 individuals will determine compliance (target >85%) and user-satisfaction (target >70%) to confirm broad acceptability and efficacy in influencing healthy sun behavior.