Lipid metabolism in the hypothalamus: implications for obesity and diabetes development

下丘脑的脂质代谢：对肥胖和糖尿病发展的影响

• 批准号: nhmrc : GNT1079233
• 负责人: Prof David Spanswick
• 金额: $ 38.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lipid-metabolism-hypothalamus-diabetes-development/1345267
• 关键词: Lipid; metabolism; hypothalamus; implications; obesity

Obesity is defined by excessive fat storage and defective lipid metabolism, not only in adipose tissue, but also in most tissues throughout the body. Obesity-induced changes in lipid metabolism extends to the brain and is associated with impaired cognitive function. This work aims to determine how obesity affects neurons in the key feeding centres of the brain, and whether excessive lipid storage in neurons induces changes in body weight regulation and metabolism.

肥胖症的定义是脂肪储存过多和脂质代谢缺陷，不仅在脂肪组织中，而且在整个身体的大多数组织中。肥胖引起的脂质代谢变化延伸到大脑，并与认知功能受损有关。这项工作旨在确定肥胖如何影响大脑关键摄食中心的神经元，以及神经元中过量的脂质储存是否会引起体重调节和代谢的变化。