Advanced Confocal Microscope in a multi-user facility
Advanced Confocal Microscope in a multi-user facility
批准号:
9274630
负责人:
Nicholas E Baker
金额:
$59.04万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-04-01 至 2018-03-31
关键词:
AgingApoptosisAutophagocytosisBiomedical ResearchBrainConfocal MicroscopyContract ServicesDevelopmental BiologyDiabetes MellitusDrosophila genusEnhancement TechnologyFundingGap JunctionsGrantHippocampus (Brain)HumanImageInflammatoryInterdisciplinary StudyInvestigationLasersMedicineMessenger RNAMicroscopeMicroscopyMinorMitochondriaNeoplasm MetastasisNeuronsRegulationResearch PersonnelResolutionScanningSpeedTechnologyThree-Dimensional ImagingTissuesUnited States National Institutes of HealthUpdateVendorbonecollegedesigndetectordevelopmental geneticsexperimental studyflexibilityfluorophoreinnovationinstrumentinstrumentationlive cell imagingrepaired
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
This application is a shared instrumentation grant from the Analytical Imaging Facility (AIF) at
the Albert Einstein College of Medicine to acquire a new, advanced point-scanning confocal
microscope. The AIF supports NIH-funded investigators by giving them access to state-of-the-
art microscopy technologies that enhance cutting edge, collaborative, and multidisciplinary
research. Currently, the AIF has several confocal microscopes available: two point-scanning
confocals, a spinning disk confocal and a line scanning confocal. However, three out of the four
existing confocal microscopes are reaching their end of usage due to aging, discontinuation of
service contracts by the vendors, and difficulties obtaining parts needed for repair. The one
remaining point-scanning confocal microscope will not be able to support the 70+ labs currently
using confocal technology at Einstein. In order to continue to support the ongoing NIH funded
biomedical research that relies on confocal microscopy, we need to replace the failing
instruments with one new confocal microscope that can offer all the functions of our current
microscopes, including regular multi-channel high resolution 3D imaging, live-cell imaging at fast
frame rates, and flexibility in channel set-up to enable use of many different fluorophores. In
addition, since the acquisition of our last confocal in 2007, there have been some major
innovations in the field of confocal microscopy with regard to detectors, laser design and
acquisition speed, and we believe that an update in technology will enable some of our NIH-
funded researchers to conduct experiments that have previously been challenging to conduct.
Overall, acquisition of this advanced instrument will have a high impact on the NIH-funded
biomedical research at Einstein, including the following major user projects: studies of the
developmental biology and genetics of Drosophila (Dr. Baker), studies of central inflammatory
regulation of systemic aging in humans (Dr. Cai), studies of cancer metastasis, invasion and
intravasation (Dr. Condeelis), mitochondrial function and mitophagy (Dr. Kitsis), the regulation of
autophagy and programmed cell death in the context of diabetes (Dr. Pessin), mechanisms of
mRNA regulation in primary hippocampal neurons and tissues (Dr. Singer) and investigation of
gap junction structural dynamics in the brain and bone (Dr. Spray). There are also additional
minor user projects and 70+ labs currently using confocal microscopy here at Einstein that will
benefit from this technology.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Cell competition, aneuploidy, and aging
-
批准号:10648670
-
项目类别:
-
资助金额:$26.06万
-
财政年份:2023
-
负责人:Nicholas E Baker
-
依托单位:
Identifying mechanisms that detect and eliminate aneuploid cells
-
批准号:10320458
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项目类别:
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资助金额:$24.03万
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财政年份:2021
-
负责人:Nicholas E Baker
-
依托单位:
Molecular Genetics of Eye Development
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批准号:10318099
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项目类别:
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资助金额:$32.4万
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财政年份:2019
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负责人:Nicholas E Baker
-
依托单位:
Ribosomes and Growth Regulation
-
批准号:9160502
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项目类别:
-
资助金额:$30.9万
-
财政年份:2016
-
负责人:Nicholas E Baker
-
依托单位:
Ribosomes and growth regulation.
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批准号:10661417
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项目类别:
-
资助金额:$33.6万
-
财政年份:2016
-
负责人:Nicholas E Baker
-
依托单位:
Mechanism of Cell Competition
-
批准号:9360551
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2016
-
负责人:Nicholas E Baker
-
依托单位:
Mechanism of Cell Competition
-
批准号:9092446
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2016
-
负责人:Nicholas E Baker
-
依托单位:
Cell Competition in Development and Homeostasis
-
批准号:10389459
-
项目类别:
-
资助金额:$3.61万
-
财政年份:2013
-
负责人:Nicholas E Baker
-
依托单位:
Cell Competition in Development and Homeostasis
-
批准号:8898115
-
项目类别:
-
资助金额:$2.64万
-
财政年份:2013
-
负责人:Nicholas E Baker
-
依托单位:
Cell Competition in Development and Homeostasis
-
批准号:8421990
-
项目类别:
-
资助金额:$31.73万
-
财政年份:2013
-
负责人:Nicholas E Baker
-
依托单位:
Cell competition in development and homeostasis
-
批准号:10250426
-
项目类别:
-
资助金额:$33.6万
-
财政年份:2013
-
负责人:Nicholas E Baker
-
依托单位:
Cell Competition in Development and Homeostasis
-
批准号:9196810
-
项目类别:
-
资助金额:$29.09万
-
财政年份:2013
-
负责人:Nicholas E Baker
-
依托单位:
Cell Competition in Development and Homeostasis
-
批准号:8737295
-
项目类别:
-
资助金额:$31.73万
-
财政年份:2013
-
负责人:Nicholas E Baker
-
依托单位:
Cell competition in development and homeostasis
-
批准号:10016338
-
项目类别:
-
资助金额:$33.38万
-
财政年份:2013
-
负责人:Nicholas E Baker
-
依托单位:
Neuronal Cell Cycle and Survival
-
批准号:8238855
-
项目类别:
-
资助金额:$37.44万
-
财政年份:2011
-
负责人:Nicholas E Baker
-
依托单位:
Neuronal Cell Cycle and Survival
-
批准号:8585071
-
项目类别:
-
资助金额:$36.82万
-
财政年份:2011
-
负责人:Nicholas E Baker
-
依托单位:
Neuronal Cell Cycle and Survival
-
批准号:8387997
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项目类别:
-
资助金额:$35.7万
-
财政年份:2011
-
负责人:Nicholas E Baker
-
依托单位:
Developmental Regulation of Growth, Size and Shape
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批准号:7919690
-
项目类别:
-
资助金额:$32.15万
-
财政年份:2009
-
负责人:Nicholas E Baker
-
依托单位:
Cell Competition: Genes That Drive Tissue Replacement
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批准号:8001038
-
项目类别:
-
资助金额:$11.46万
-
财政年份:2008
-
负责人:Nicholas E Baker
-
依托单位:
Cell Competition: Genes That Drive Tissue Replacement
-
批准号:7599007
-
项目类别:
-
资助金额:$20.75万
-
财政年份:2008
-
负责人:Nicholas E Baker
-
依托单位:
国内基金
海外基金
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