Dexterous BMIs for tetraplegic humans utilizing somatosensory cortex stimulation
Dexterous BMIs for tetraplegic humans utilizing somatosensory cortex stimulation
批准号:
9357398
负责人:
RICHARD A ANDERSEN
金额:
$77.03万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-30 至 2019-08-31
关键词:
Activities of Daily LivingAdvanced DevelopmentAlgorithmsAnteriorAreaBehaviorBrodmann&aposs areaCerebral cortexClinical TrialsCognitiveCuesDetectionDevelopmentDiscriminationEsthesiaFeedbackFrequenciesFutureGoalsHandHumanImplantInstitutional Review BoardsLearningLimb structureLocationMethodsMorphologic artifactsMotorMotor outputMovementMovement DisordersNeckNeurodegenerative DisordersNeuronsParalysedParietal LobePathway interactionsPatientsPerceptionPerformancePositioning AttributePrimatesProcessPropertyProprioceptionProsthesisQuadriplegiaReportingRoboticsScientific Advances and AccomplishmentsShapesSomatosensory CortexSpinal Cord LesionsSpinal cord injuryStimulusStrokeTactileTechniquesTestingTimeUser-Computer InterfaceVisionVisualbasebrain machine interfacedesigndisabilityfinger movementgraspimplantationmicrostimulationmind controlmulti-electrode arraysneuroprosthesisneurotransmissionnonhuman primateperformance testsrelating to nervous systemrobot controlsomatosensorysomesthesisstatistical centersuccessvisual feedback
中文摘要
项目摘要/摘要
将在四肢瘫痪的人类身上研究伸手抓住和手操作,神经记录来自于
体感皮层的多电极阵列(MEAs)和皮质内微刺激(ICMS)。录音
将在皮质抓握环路内进行,并在两个抓握相关区域植入MEA,腹侧
运动前皮质(PMV)和后顶叶皮质的前顶内区(AIP)。ICM将
被传递到躯体感觉皮质的Brodmann区1(BA1)。目标1将比较来自PMV的录音
和AIP来确定这两个区域如何处理抓取。我们将检验AIP是
更关注高水平的目标,PMV更关注运动轨迹。这些结果将是重要的
用于为未来的神经假体开发选择植入区域。目标2将检查触觉
ICMS可以提供的提示。我们假设对刺激的检测、辨别和定位
通过改变ICMS的频率、幅度和位置参数来感知。这些发现将是
用于为脑机接口(BMI)应用提供刺激诱导的触觉反馈。在AIM 3中
我们将使用三项任务,将解码来自AIP和PMV的神经信号与ICMS结合用于躯体感觉
双向BMI的反馈。这些任务将用于测试BMI性能(1)的频率和
无视觉反馈的ICMS的幅度辨别(手袋任务),(2)基于学习的
本体感觉,以及(3)实施力反馈以调整抓取的机械手任务。我们
假设患者将成功完成这些任务,表明双向BMI
可行的,可以传递触觉和本体感觉的信息,用于抓取和手操作。我们有
已经开发了人工排斥技术,并演示了它们在非人灵长类动物中的应用
(NHP)双向BMI任务。我们还获得了这些研究的所有监管批准,并已经
在使用PPC记录的四肢瘫痪患者中成功地应用了BMI。因此,前景对
在3年内成功完成这些目标。这些目标的结果将推动科学
大脑皮层GRAP加工的理解和双向加工的发展与实现
BMI用于帮助有运动障碍的患者。
英文摘要
Project summary/abstract
Reach-to-grasp and hand manipulation will be studied in tetraplegic humans with neural recordings from
multielectrode arrays (MEAs) and intracortical microstimulation (ICMS) of somatosensory cortex. Recordings
will be performed within the cortical grasp circuit with MEAs implanted in two grasp-related areas, the ventral
premotor cortex (PMv) and the anterior intraparietal area (AIP) of the posterior parietal cortex (PPC). ICMS will
be delivered to Brodmann's area 1 (BA1) of somatosensory cortex. Aim 1 will compare recordings from PMv
and AIP to determine how grasping is processed by these two areas. We will test the hypothesis that AIP is
more concerned with high-level goals and PMv more with motor trajectories. These results will be important
for selecting areas for implantation for future neurosprosthetics development. Aim 2 will examine the tactile
cues that can be provided by ICMS. We hypothesize that detection, discrimination, and location of stimuli will
be perceived by varying parameters of frequency, amplitude and location of the ICMS. These findings will be
used for providing stimulation induced tactile feedback for brain-machine interface (BMI) applications. In aim 3
we will use three tasks that combine decoding neural signals from AIP and PMv with ICMS for somesthetic
feedback for a bidirectional BMI. The tasks will be used to test BMI performance (1) for frequency and
amplitude discrimination of ICMS without visual feedback (“handbag task”), (2) for learning-based
proprioception, and (3) a manipulandum task that implements force feedback for adjusting grasp. We
hypothesize that the patients will successfully perform these tasks, indicating that bidirectional BMIs are
feasible and can deliver tactile and proprioceptive information for grasp and hand manipulation. We have
already developed artifact rejection techniques and demonstrated their application in a non-human primate
(NHP) bidirectional BMI task. We also have all of the regulatory approvals for these studies and already have
had success with BMI applications in tetraplegic patients using PPC recordings. Thus the outlook is good for
successful completion of these aims within 3 years. The results of these aims will advance both the scientific
understanding of grasp processing in human cortex and the development and implementation of bidirectional
BMIs to assist patients with movement disorders.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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