High Energy Density Polymer Film Capacitors for ICDs

用于 ICD 的高能量密度聚合物薄膜电容器

• 批准号: 9201398
• 负责人: Henry Angelo Sodano
• 金额: $ 15万
• 依托单位: HARP ENGINEERING, LLC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9201398
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Aging; Aluminum; Automobile Driving; Boston; Cessation of life; Chest; Child; Childhood; Development; Devices; Drops; Electric Capacitance; Electric Countershock; Electrolytes; Engineering; Ensure; Failure; Film; Future; Heart; Heart Arrest; Implant; Implantable Defibrillators; Intravenous; Lead; Liquid substance; Malignant neoplasm of lung; Medical; Methods; Military Personnel; Nature; Operative Surgical Procedures; Patients; Phase; Physiologic pulse; Polyethylenes; Polymers; Polypropylenes; Process; Production; Prunella vulgaris; Quality of life; Reporting; Resistance; Risk; Safety; Saint Jude Children' s Research Hospital; Series; Shock; Skin; Small Business Innovation Research Grant; Sudden Death; Technology; Testing; Thick; Time; United States; Ventricular Fibrillation; Ventricular Tachycardia; boson; design; energy density; heart rhythm; implantable device; implantation; improved; malignant breast neoplasm; meetings; prototype; research and development; solid state; subcutaneous; sudden cardiac death; voltage

Project Summary: An implantable cardioverter defibrillator (ICD) is a small battery powered electric pulse generator about the size of a stopwatch that is implanted into the chest of patients who are at risk of sudden cardiac death due to ventricular fibrillation and ventricular tachycardia. The ICD uses a capacitor to deliver a shock (defibrillation) to the heart, which stops the abnormal rhythm. Without this therapy, the dangerously rapid rhythm could lead to sudden cardiac arrest and sudden cardiac death within minutes. Sudden death due to cardiac arrest affects 330,000 people each year in the United States alone (meaning that almost 1,000 people die from it each day). ICDs have been shown to effectively stop 95% or more of these dangerously fast heart rhythms. ICDs place unique requirements on the capacitor used to generate the electrical pulse, requiring a combination of high voltage, high capacitance, and small case size. While metalized polymer film capacitors are used AEDs, the energy density of current materials is too low to be used in implantable devices. Without the availability of high energy density polymer films, ICDs have been limited to aluminum electrolytic capacitors, which are undesirable for many reasons resulting from the use of a liquid electrolyte. Polymer film capacitors are solid state and thus require no volatile compounds that would pose safety risks once implanted. Existing polymer film capacitors, such as those produced from polypropylene or polyethylene, have a low volumetric capacitance and low energy density (~1.2J/cc) making them unsuitable for ICDs. HARP Engineering recently developed a new composition for thin film capacitors that provides the highest energy density ever reported. This technology is would allow a 7.7 times smaller capacitor than the aluminum electrolytic capacitors used in current implantable cardioverter defibrillators (ICDs) and a 28.7% reduction in total device volume. Since ICDs are implanted, the package size is critical to the patient's quality of life after surgery, especially in pediatric cases and the reduction of late complications, such as skin erosion, which is highly impacted by the size of the device and reported to occur in 0.9% of cases. Furthermore, the more recent development of subcutaneous ICDs which eliminate complications from intravenous leads require roughly three times greater energy to achieve defibrillation thus producing even greater need for smaller capacitors. Under this SBIR, HARP Engineering proposes to collaborate with St. Jude Medical and Boston Scientific to manufacture, test and demonstrate ultra high energy density capacitors for use in ICDs.

项目概要： 植入式心律转复除颤器（ICD）是一种小型电池供电的电脉冲 一个大约秒表大小的发生器，被植入病人的胸部， 由于室颤和室性心动过速导致的心源性猝死风险。的ICD 使用电容器向心脏提供电击（除颤），从而停止异常心律。 如果没有这种治疗，危险的快速心律可能导致心脏骤停， 几分钟内心脏性猝死因心脏骤停而猝死影响33万人 仅在美国，每年就有1,000人死于这种疾病（这意味着每年有近1,000人死于这种疾病）。 天）。ICD已被证明可以有效地阻止95%或更多的这些危险的快速心脏 节奏 ICD对用于产生电脉冲的电容器提出了独特的要求， 高电压、高电容和小外壳尺寸的组合。虽然金属化聚合物 薄膜电容器用于AED，当前材料的能量密度太低而不能用于AED。 植入式装置在没有高能量密度聚合物膜的情况下，ICD具有 由于许多原因，铝电解电容器是不理想的 这是由于使用了液体电解质。聚合物薄膜电容器是固态的，因此 不需要挥发性化合物，这些化合物一旦植入就会造成安全风险。现有聚合物 薄膜电容器，例如由聚丙烯或聚乙烯生产的那些，具有低的 体积电容和低能量密度（~1.2J/cc）使其不适合ICD。 HARP Engineering最近开发了一种用于薄膜电容器的新组合物， 有史以来最高的能量密度这项技术将使一个比现有技术小7.7倍 电容器比在当前植入式心律转复器中使用的铝电解电容器 植入式心脏复律除颤器（ICD）和总器械体积减少28.7%。由于植入了ICD， 包装尺寸对患者术后的生活质量至关重要，尤其是在儿科中 病例和减少晚期并发症，如皮肤糜烂，这是高度影响 器械尺寸，报告发生率为0.9%。此外，最近 开发皮下ICD，消除静脉电极导线的并发症 需要大约三倍的能量来实现除颤， 需要更小的电容器。根据该SBIR，HARP工程公司建议与 圣Jude Medical和Boston Scientific将生产、测试和演示超高能量 用于ICD的高密度电容器。