International Research Training on TB and Other Pulmonary Complications of HIV

描述(由申请人提供)：拟议的培训计划，建立在艾滋病毒/艾滋病相关研究和培训的20年合作历史的基础上，将针对在MAKCHS、穆拉戈国家转诊医院或附属非政府组织工作并渴望从事以患者为导向的研究的初级研究人员。目前的提案寻求增加翻译研究的机会，乌干达和美国的调查人员认为这是一个严重的未得到充分代表的需求。通过在多学科环境中提供定制的教学培训和实践研究经验，该计划将培养来自不同专业背景的个人，为翻译研究团队做出贡献；这种团队建设代表着一种有效且具有潜在变革性的方法，以推进艾滋病毒感染肺部并发症这一重要、未被研究和固有的跨学科内容领域的研究。学员将参加MAKCHS现有的硕士学位课程，或在特定情况下，参加授予学位的远程学习项目，或伦敦卫生与热带医学院或加州大学旧金山分校的个别课程。被选中的学员将在美国的一所参与机构度过有限的时间，在那里他们将参加MAKCHS没有的高级课程和密集的实验室经验；接受指导，为他们竞争独立资助做好准备；在数据分析阶段获得分析、口译和准备摘要和手稿方面的帮助；以及从其他类型的职业发展和教师指导活动中受益。所有受训人员将在接受教学培训的同时进行纵向国内研究项目。这些研究项目将尽可能利用目前由美国国立卫生研究院资助的乌干达艾滋病毒/艾滋病相关研究项目收集的数据和标本，或建立这些项目的现有研究基础设施。学员将有资格参加竞争，并获得适当的研究项目资金。将优先考虑培训和研究 侧重于获取和应用翻译研究方法，并承诺加强多学科研究团队的建议。培训计划的结果将是增加MAKCHS教职员工的数量，他们对结核病和艾滋病毒的其他肺部并发症进行高质量的、与当地相关的研究，这反过来将有助于改善乌干达和其他高负担国家的艾滋病毒/艾滋病结果。

DESCRIPTION (provided by applicant): The proposed training program, which builds on a > 20 year history of collaboration in HIV/AIDS-related research and training, will target junior investigators who are based at MAKCHS, Mulago National Referral Hospital, or affiliated non-governmental organizations and aspire to careers in patient-oriented research. The current proposal seeks to enhance opportunities in translational research, which has been identified by Ugandan and U.S. investigators as a critical under-represented need. By offering customized didactic training and practical research experiences in a multi-disciplinary environment, the program will prepare individuals from diverse professional backgrounds to contribute to translational research teams; this team-building represents an efficient and potentially transformative approach to advancing research in the important, under-studied, and inherently inter-disciplinary content area of pulmonary complications of HIV infection. Trainees will be enrolled either in existing masters degree programs at MAKCHS or, in selected circumstances, in degree-conferring distance-learning programs or individual courses at the London School of Hygiene and Tropical Medicine or UCSF. Selected trainees will spend limited blocks of time in the U.S. at one of the participating U.S. institutions, where they will undertake advanced courses and intensive laboratory experiences not available at MAKCHS; receive mentoring to prepare them to compete for independent grant funding; obtain assistance with analysis, interpretation, and preparation of abstracts and manuscripts at the data analysis stage; and benefit from other types of career development and faculty mentoring activities. All trainees will pursue longitudinal in-country research projects alongside their didactic training. These research projects will, whenever possible, take advantage of data and specimens being collected through current collaborative NIH-funded HIV/AIDS-related research projects in Uganda, or build on the existing research infrastructure of these projects. Trainees will be eligible to compete for and receive modest funding for their research projects. Priority will be given to training and research proposals that focus on the acquisition and application of translational research methods and that promise to strengthen multi- disciplinary research teams. The result of the training program will be an increase in the number of MAKCHS faculty conducting high quality, locally relevant research on TB and other pulmonary complications of HIV, which will in turn help improve HIV/AIDS outcomes in Uganda and other high-burden countries.