International Research Training on TB and Other Pulmonary Complications of HIV

描述（由申请人提供）：拟议的培训计划建立在20多年来在艾滋病毒/艾滋病相关研究和培训方面的合作基础上，针对的是在MAKCHS、穆拉戈国家转诊医院或附属非政府组织工作的初级研究人员，他们渴望从事以患者为导向的研究工作。目前的建议寻求增加转化研究的机会，乌干达和美国的研究人员已经确定这是一个严重的未被充分代表的需求。通过在多学科环境中提供定制的教学培训和实践研究经验，该计划将培养来自不同专业背景的个人为翻译研究团队做出贡献；这种团队建设代表了一种有效的、潜在的变革性方法，可以推进HIV感染肺部并发症这一重要的、研究不足的、固有的跨学科内容领域的研究。受训人员将被选读现有的硕士学位课程，或者在特定情况下，被选读伦敦卫生和热带医学学院（UCSF）授予学位的远程学习课程或个人课程。被选中的学员将在美国的一个参与机构度过有限的时间，在那里他们将学习在MAKCHS没有的高级课程和强化实验室经验；接受指导，为他们争取独立拨款资金做好准备；在数据分析阶段获得分析、解释和准备摘要和手稿方面的协助；并从其他类型的职业发展和教师指导活动中受益。所有受训者将在接受教学训练的同时进行纵向的国内研究项目。只要有可能，这些研究项目将利用目前由美国国立卫生研究院资助的乌干达艾滋病毒/艾滋病相关研究项目收集的数据和标本，或以这些项目的现有研究基础设施为基础。学员将有资格为他们的研究项目竞争并获得适度的资助。将优先考虑培训和研究

DESCRIPTION (provided by applicant): The proposed training program, which builds on a > 20 year history of collaboration in HIV/AIDS-related research and training, will target junior investigators who are based at MAKCHS, Mulago National Referral Hospital, or affiliated non-governmental organizations and aspire to careers in patient-oriented research. The current proposal seeks to enhance opportunities in translational research, which has been identified by Ugandan and U.S. investigators as a critical under-represented need. By offering customized didactic training and practical research experiences in a multi-disciplinary environment, the program will prepare individuals from diverse professional backgrounds to contribute to translational research teams; this team-building represents an efficient and potentially transformative approach to advancing research in the important, under-studied, and inherently inter-disciplinary content area of pulmonary complications of HIV infection. Trainees will be enrolled either in existing masters degree programs at MAKCHS or, in selected circumstances, in degree-conferring distance-learning programs or individual courses at the London School of Hygiene and Tropical Medicine or UCSF. Selected trainees will spend limited blocks of time in the U.S. at one of the participating U.S. institutions, where they will undertake advanced courses and intensive laboratory experiences not available at MAKCHS; receive mentoring to prepare them to compete for independent grant funding; obtain assistance with analysis, interpretation, and preparation of abstracts and manuscripts at the data analysis stage; and benefit from other types of career development and faculty mentoring activities. All trainees will pursue longitudinal in-country research projects alongside their didactic training. These research projects will, whenever possible, take advantage of data and specimens being collected through current collaborative NIH-funded HIV/AIDS-related research projects in Uganda, or build on the existing research infrastructure of these projects. Trainees will be eligible to compete for and receive modest funding for their research projects. Priority will be given to training and research proposals that focus on the acquisition and application of translational research methods and that promise to strengthen multi- disciplinary research teams. The result of the training program will be an increase in the number of MAKCHS faculty conducting high quality, locally relevant research on TB and other pulmonary complications of HIV, which will in turn help improve HIV/AIDS outcomes in Uganda and other high-burden countries.