International Research Training on TB and Other Pulmonary Complications of HIV

描述（由申请人提供）：拟议的培训计划建立在艾滋病毒/艾滋病相关研究和培训合作的20年历史基础上，将针对MAKCHS，Mulago国家转诊医院或附属非政府组织的初级研究人员，并渴望从事以患者为导向的研究。目前的提案旨在增加转化研究的机会，乌干达和美国的调查人员已将其确定为一个关键的代表性不足的需求。通过在多学科环境中提供定制的教学培训和实践研究经验，该计划将为来自不同专业背景的个人做好准备，为翻译研究团队做出贡献;这种团队建设代表了一种有效且具有潜在变革性的方法，以推进艾滋病毒感染肺部并发症的重要，研究不足和固有的跨学科内容领域的研究。学员将在MAKCHS现有的硕士学位课程或在选定的情况下，在学位授予远程学习课程或个人课程在卫生和热带医学或加州大学旧金山分校的伦敦学校注册。被选中的学员将在美国的一个参与美国机构度过有限的时间，在那里他们将参加MAKCHS没有的高级课程和密集的实验室经验;接受指导，为他们竞争独立的赠款资金做好准备;在数据分析阶段获得分析，解释和编写摘要和手稿的帮助;并受益于其他类型的职业发展和教师指导活动。所有受训人员将在进行教学培训的同时进行国内纵向研究项目。这些研究项目将尽可能利用目前由美国国立卫生研究院资助的乌干达艾滋病毒/艾滋病相关研究项目收集的数据和标本，或利用这些项目现有的研究基础设施。学员将有资格竞争并获得适度的研究项目资金。将优先考虑培训和研究 建议书的重点是转化研究方法的获得和应用，并承诺加强多学科的研究团队。培训计划的结果将是，MAKCHS教师的数量将增加，他们将对结核病和艾滋病毒的其他肺部并发症进行高质量的、与当地相关的研究，这反过来将有助于改善乌干达和其他高负担国家的艾滋病毒/艾滋病成果。

DESCRIPTION (provided by applicant): The proposed training program, which builds on a > 20 year history of collaboration in HIV/AIDS-related research and training, will target junior investigators who are based at MAKCHS, Mulago National Referral Hospital, or affiliated non-governmental organizations and aspire to careers in patient-oriented research. The current proposal seeks to enhance opportunities in translational research, which has been identified by Ugandan and U.S. investigators as a critical under-represented need. By offering customized didactic training and practical research experiences in a multi-disciplinary environment, the program will prepare individuals from diverse professional backgrounds to contribute to translational research teams; this team-building represents an efficient and potentially transformative approach to advancing research in the important, under-studied, and inherently inter-disciplinary content area of pulmonary complications of HIV infection. Trainees will be enrolled either in existing masters degree programs at MAKCHS or, in selected circumstances, in degree-conferring distance-learning programs or individual courses at the London School of Hygiene and Tropical Medicine or UCSF. Selected trainees will spend limited blocks of time in the U.S. at one of the participating U.S. institutions, where they will undertake advanced courses and intensive laboratory experiences not available at MAKCHS; receive mentoring to prepare them to compete for independent grant funding; obtain assistance with analysis, interpretation, and preparation of abstracts and manuscripts at the data analysis stage; and benefit from other types of career development and faculty mentoring activities. All trainees will pursue longitudinal in-country research projects alongside their didactic training. These research projects will, whenever possible, take advantage of data and specimens being collected through current collaborative NIH-funded HIV/AIDS-related research projects in Uganda, or build on the existing research infrastructure of these projects. Trainees will be eligible to compete for and receive modest funding for their research projects. Priority will be given to training and research proposals that focus on the acquisition and application of translational research methods and that promise to strengthen multi- disciplinary research teams. The result of the training program will be an increase in the number of MAKCHS faculty conducting high quality, locally relevant research on TB and other pulmonary complications of HIV, which will in turn help improve HIV/AIDS outcomes in Uganda and other high-burden countries.