A web-based platform for cross-linguistic research in dysarthric speech

描述（由申请人提供）：据我们估计，全球93%的构音障碍患者，或4300万人，要么不会说英语，要么是双语或多语。然而，构音障碍对英语以外语言的交际功能的影响几乎是未知的。这是因为我们描述和治疗构音障碍的机制是以英语为中心的，也就是说，基于英语的节奏和语音。然而，其他语言的不同节奏模式和语音清楚地表明，其他语言中的构音障碍（例如，西班牙语）将导致非常不同的生产后果的人与构音障碍，和非常不同的感知挑战，他们的沟通伙伴。尽管如此，目前还没有系统的研究跨语言运动言语障碍的后果，也没有机制来描述或解决，构音障碍在英语以外的语言。这在美国提出了一个重要的医疗保健问题，估计有300万患有构音障碍的人中有50多万人是双语或非英语发言者。我们可以解决这个问题。这项提案的总体目标是建立并免费提供一个构音障碍言语的跨语言视听数据库。该数据库将由来自讲英语和/或西班牙语的构音障碍患者的语音样本组成，所有数据都将标记有传记特征、时间对齐的正射转录以及与节奏模式、发音完整性和可懂度声学指标中的语音退化模式相关的量化声学数据。这个数据库将很容易搜索，数据将很容易导出。我们的国际合作具有独特的优势，可以实现这一目标。我们有现有的基础设施和资源，可以利用来建立数据库;我们已经开发了一个工作模型，通过它来探索构音障碍的跨语言交流功能;我们已经开发和测试了一系列自动声学指标，这些指标可以捕获语音节奏，发音完整性以及来源和过滤器特征;我们将开发一个 通用的语音刺激模板，从跨语言研究通信功能。该提案将这些组件结合在一起，并作为随后的R 01提案的基础，该提案旨在对英语和西班牙语中的构音障碍、语言和交际功能进行假设驱动的调查。该研究平台的开发为科学知识的快速发展提供了机会，这些知识可以直接转化为临床实践。

DESCRIPTION (provided by applicant): By our estimation 93% of people with dysarthria worldwide, or 43 million people, either do not speak English or are bi- or multi-lingual. However, the consequences of dysarthria on communicative function in languages other than English are virtually unknown. This is because our mechanisms for describing and treating dysarthria are English-language centric-that is, based on the rhythm and phonology of the English language. However, the differing rhythm patterns and speech sounds of other languages make it patently clear that dysarthria in other languages (e.g., Spanish) will result in very different production consequences for people with dysarthria, and very different perceptual challenges for their communicative partners. While that is the case, there has been no systematic research on the consequences of motor speech disorders across languages and there is no mechanism to describe, or address, dysarthria in languages other than English. This presents a significant health-care issue here in the US, in which over 500,000 of the estimated three million people with dysarthria are either bilingual, or non-English speakers. We can address this issue. The overall goal of this proposal is to build, and make freely available, a cross-linguistic audio-visul database of dysarthric speech. The database will be comprised of speech samples from people with dysarthria who speak English and/or Spanish and all data will be tagged with biographical characteristics, time-aligned orthographic transcription, and quantified acoustic data related to patterns of speech degradation in rhythm patterns, articulatory integrity, and intelligibility acoustic metrics. This database will be easy to search, and data will be easy to export. Our international collaboration is uniquely placed to make this happen. We have existing infrastructure and resources that can be leveraged to build the database; we have developed a working model through which to explore cross-linguistic communication function in dysarthria; we have developed and tested battery of automated acoustic metrics that capture aspects of speech rhythm, articulatory integrity, and source and filter characteristics; and we will develop a universal speech stimuli template from which to study communication function cross-linguistically. This proposal brings these components together, and serves as the foundation for a subsequent R01 proposal aimed at hypothesis driven investigations of dysarthria, language, and communicative function in English and Spanish. The development of this research platform offers the opportunity for rapid advances in scientific knowledge, which can be directly translated to clinical practice.