A web-based platform for cross-linguistic research in dysarthric speech

描述（由申请人提供）：据我们估计，全球93%的构音障碍患者，即4300万人，要么不会说英语，要么会说两种或多种语言。然而，构音障碍对英语以外语言交际功能的影响几乎是未知的。这是因为我们描述和治疗构音障碍的机制是以英语为中心的，也就是说，基于英语语言的节奏和音韵。然而，其他语言不同的节奏模式和语音清楚地表明，其他语言（如西班牙语）的构音障碍会给患有构音障碍的人带来非常不同的生产后果，也会给他们的交际伙伴带来非常不同的感知挑战。尽管如此，目前还没有关于运动语言障碍的跨语言后果的系统研究，也没有机制来描述或解决除英语以外的语言中的构音障碍。这在美国提出了一个重大的卫生保健问题，在美国，估计有300万患有构音障碍的人中，有50多万人要么是双语者，要么是非英语者。我们可以解决这个问题。本提案的总体目标是建立并免费提供一个跨语言的困难言语视听数据库。该数据库将由说英语和/或西班牙语的构音障碍患者的语音样本组成，所有数据将被标记为传记特征，时间对齐的正字法转录，以及与节奏模式，发音完整性和可理解性声学指标中的语音退化模式相关的量化声学数据。这个数据库将很容易搜索，数据将很容易导出。我们的国际合作是实现这一目标的独特条件。我们现有的基础设施和资源可以用来建立数据库；我们开发了一个工作模型，通过它来探索构音障碍的跨语言交际功能；我们已经开发和测试了一组自动声学指标，可捕获语音节奏，发音完整性以及源和滤波器特性的各个方面；我们将开发一个

DESCRIPTION (provided by applicant): By our estimation 93% of people with dysarthria worldwide, or 43 million people, either do not speak English or are bi- or multi-lingual. However, the consequences of dysarthria on communicative function in languages other than English are virtually unknown. This is because our mechanisms for describing and treating dysarthria are English-language centric-that is, based on the rhythm and phonology of the English language. However, the differing rhythm patterns and speech sounds of other languages make it patently clear that dysarthria in other languages (e.g., Spanish) will result in very different production consequences for people with dysarthria, and very different perceptual challenges for their communicative partners. While that is the case, there has been no systematic research on the consequences of motor speech disorders across languages and there is no mechanism to describe, or address, dysarthria in languages other than English. This presents a significant health-care issue here in the US, in which over 500,000 of the estimated three million people with dysarthria are either bilingual, or non-English speakers. We can address this issue. The overall goal of this proposal is to build, and make freely available, a cross-linguistic audio-visul database of dysarthric speech. The database will be comprised of speech samples from people with dysarthria who speak English and/or Spanish and all data will be tagged with biographical characteristics, time-aligned orthographic transcription, and quantified acoustic data related to patterns of speech degradation in rhythm patterns, articulatory integrity, and intelligibility acoustic metrics. This database will be easy to search, and data will be easy to export. Our international collaboration is uniquely placed to make this happen. We have existing infrastructure and resources that can be leveraged to build the database; we have developed a working model through which to explore cross-linguistic communication function in dysarthria; we have developed and tested battery of automated acoustic metrics that capture aspects of speech rhythm, articulatory integrity, and source and filter characteristics; and we will develop a universal speech stimuli template from which to study communication function cross-linguistically. This proposal brings these components together, and serves as the foundation for a subsequent R01 proposal aimed at hypothesis driven investigations of dysarthria, language, and communicative function in English and Spanish. The development of this research platform offers the opportunity for rapid advances in scientific knowledge, which can be directly translated to clinical practice.