Unified high performance analysis of imaging biomarkers for Alzheimer's disease

阿尔茨海默病成像生物标志物的统一高性能分析

• 批准号: 9108816
• 负责人: Ronald Pierson
• 金额: $ 60万
• 依托单位: PIERSON BRAIN IMAGE ANALYSIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9108816
• 关键词: Adverse effects; Affect; Alzheimer' s Disease; Amyloid; Area; Atrophic; Biological Markers; Biological Neural Networks; Brain; Brain imaging; Cerebrum; Cessation of life; Clinic; Clinical; Clinical Trials; Complex; Computer software; Data; Data Set; Databases; Dementia; Dentate nucleus; Diagnosis; Diagnostic; Diagnostic Imaging; Disease Progression; Ensure; Failure; Goals; Health; Hippocampus (Brain); Image; Image Analysis; Impaired cognition; Impairment; Individual; Injury; Intervention; Licensing; Light; Lobe; Magnetic Resonance Imaging; Measurement; Measures; Memory; Methods; Modality; Monitor; Monitoring Clinical Trials; Morphologic artifacts; Morphology; Myelin; National Institute on Aging; Neurodegenerative Disorders; Parietal Lobe; Pathology; Performance; Perfusion; Pharmaceutical Preparations; Phase; Positron-Emission Tomography; Process; Production; Protocols documentation; Quality Control; Reporting; Research; Research Personnel; Sensitivity and Specificity; Spin Labels; Structure; Temporal Lobe; Testing; Thick; Time; Validation; Vascular Diseases; White Matter Hyperintensity; Work; base; beta-site APP cleaving enzyme 1; clinical application; cognitive function; design; fluorodeoxyglucose positron emission tomography; glucose metabolism; high throughput analysis; hypoperfusion; imaging biomarker; interest; morphometry; potential biomarker; skills; study population; white matter

DESCRIPTION (provided by applicant): Alzheimer's disease is a neurodegenerative disease of the brain causing impairments to memory and cognitive functions, eventually leading to death. The causes of Alzheimer's disease and mechanisms of disease progression are not fully understood, but an enormous amount of effort is being focused on the issues in research and pharmacologic interventions. Brain Image Analysis, LLC has developed NeuroAnalytica to provide high quality brain morphometry measures for biomarkers in Alzheimer's disease. This Phase II project will expand the basic measures to include a wide range of modalities and measures that research has shown to be useful in as potential biomarkers in Alzheimer's disease.

描述（由申请人提供）：阿尔茨海默病是一种大脑神经退行性疾病，导致记忆和认知功能受损，最终导致死亡。阿尔茨海默病的病因和疾病进展的机制尚未完全了解，但大量的努力正在集中在研究和药物干预的问题上。Brain Image Analysis，LLC开发了NeuroAnalytica，为阿尔茨海默病的生物标志物提供高质量的脑形态测量。这个第二阶段项目将扩大基本措施，包括广泛的模式和措施，研究表明，在阿尔茨海默病的潜在生物标志物是有用的。