Core Grant for Vision Research

视觉研究核心资助

• 批准号: 9355329
• 负责人: JERRY NIEDERKORN
• 金额: $ 35.02万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355329
• 关键词: Advocate; Applications Grants; Award; Cancer Grant Supplements (P30); Center Core Grants; Collaborations; Communities; Core Grant; Developmental Biology; Faculty; Fostering; Funding; Future; Gene Transfer; Grant; Growth; Health; Hybridomas; Image; Individual; Institution; Instruction; Intramural Research; Journals; Laboratories; Mediating; Medical center; Monoclonal Antibody R24; Neurosciences; Ophthalmology; Outcome; Peer Review; Physiology; Postdoctoral Fellow; Production; Protein Biochemistry; Psychiatry; Publications; Recombinant Proteins; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Scientist; Series; Technology; Texas; Universities; Virus; Vision; Vision research; career; graduate student; hybridoma production; medical schools; member; ocular surface; ranpirnase; recombinant virus; tissue culture; vector; vision science

DESCRIPTION (provided by applicant): A Core Center Grant is proposed to support vision research at the University of Texas Southwestern Medical Center. Investigators in the Department of Ophthalmology recently completed a 5-year infrastructure grant (R24) that supported ocular surface research on our campus. The infrastructure grant was enormously successful and fostered new collaborations and culminated in 69 publications in peer-review journals. We recently received a one-year P30 Core Grant through the ARRA. This unique one-year award has fostered further collaborations among vision researchers from the Departments of Ophthalmology, Psychiatry, Physiology, Neuroscience, and the Center for Developmental Biology at the University of Texas Southwestern Medical Center. We have also initiated a number of vision-related projects and seminar series that have enriched vision research activities on this campus. This, along with the acquisition of additional NEl-supported research, prompted us to submit a 5-year P30 Core Grant application to enhance and expand research efforts that rely on three common technologies: 1) tissue culture/hybridoma; 2) imaging; and 3) protein biochemistry and virus-mediated gene transfer. Significant institutional support in the form of additional laboratory space, endowed scholars' awards, and intramural research awards has provided a fertile ground for expansion and enhancement of vision research on our campus. The proposed Core Grant for Vision Research will further this effort and enhance vision research at the University of Texas Southwestern Medical Center.

描述（由申请人提供）：一项核心中心拨款被提议用于支持德克萨斯大学西南医学中心的视觉研究。眼科的研究人员最近完成了一项为期5年的基础设施拨款（R24），以支持我们校园的眼表研究。基础设施拨款取得了巨大成功，促进了新的合作，最终在同行评议期刊上发表了69篇论文。我们最近通过ARRA获得了为期一年的P30核心补助金。这个独一无二的为期一年的奖项促进了来自眼科、精神病学、

项目成果

Evidence of Alternative Cystatin C Signal Sequence Cleavage Which Is Influenced by the A25T Polymorphism.

受 A25T 多态性影响的替代胱抑素 C 信号序列切割的证据。

• DOI: 10.1371/journal.pone.0147684
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Nguyen,Annie;Hulleman,JohnD
• 通讯作者: Hulleman,JohnD

Investigational Rho Kinase Inhibitors for the Treatment of Glaucoma.

• DOI: 10.2147/jep.s259297
• 发表时间: 2021
• 期刊: Journal of experimental pharmacology
• 作者: Al-Humimat G;Marashdeh I;Daradkeh D;Kooner K
• 通讯作者: Kooner K

NKT cells act through third party bone marrow-derived cells to suppress NK cell activity in the liver and exacerbate hepatic melanoma metastases.

• DOI: 10.1002/ijc.29480
• 发表时间: 2015-09-01
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: Sadegh L;Chen PW;Brown JR;Han Z;Niederkorn JY
• 通讯作者: Niederkorn JY

Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye.

• DOI: 10.1016/j.ghir.2018.02.001
• 发表时间: 2018-06
• 期刊: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
• 作者: Patel R;Zhu M;Robertson DM
• 通讯作者: Robertson DM

NKT cell exacerbation of liver metastases arising from melanomas transplanted into either the eyes or spleens of mice.

• DOI: 10.1167/iovs.10-7067
• 发表时间: 2011-05
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Wanhua Yang;Haochuan Li;E. Mayhew;J. Mellon;Peter W. Chen;J. Niederkorn