权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Pediatric Asthma Disparities: The Role of Sleep and Immune Balance

小儿哮喘差异：睡眠和免疫平衡的作用

基本信息

批准号：
9207483
负责人：
Daphne Koinis Mitchell
金额：
$ 10.15万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-02-01 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9207483
关键词：
10 year old Address Adherence Adult Affect Age Area Asthma Beds Behavior Behavior Therapy Behavior assessment Biological Biological Markers Caregivers Child Childhood Childhood Asthma Chronic Clinical Clinical Immunology Crowding Data Development Disease Drowsiness Eligibility Determination Equilibrium Ethics Evaluation Experimental Designs Extrinsic asthma Faculty Fellowship Program Funding Goals Grant Growth and Development function Home environment Human Immune Immunologic Markers Inflammation Inflammatory Interferon-alpha Interleukin-13 Interleukin-4 Interleukin-5 Interleukin-6 Interleukins Intervention Intervention Studies Investigation K-Series Research Career Programs Knowledge Link Longitudinal Studies Mentors Mentorship Methods Minority Nocturnal Asthma Outcome Performance Physiology Plasma Polysomnography Postdoctoral Fellow Process Protocols documentation Psychiatry Pulmonary Function Test/Forced Expiratory Volume 1 Recording of previous events Recruitment Activity Reporting Research Research Design Research Infrastructure Research Project Grants Resources Respiratory physiology Risk Role Schedule Schools Sleep Sleep Fragmentations Sleep disturbances Spirometry Symptoms Testing Time Training Training Activity Universities Work actigraphy base career cytokine elementary school ethnic diversity health disparity improved innovation interest medical schools mid-career faculty minority children patient oriented research phenomenological models primary caregiver programs public health relevance statistics training opportunity treatment response urban children urban poverty vigilance

项目摘要

DESCRIPTION (provided by applicant): This K24 application proposes a mentorship program in patient-oriented research in multi-level contributors to pediatric asthma health disparities, wih a focus on sleep and immune balance. The K24 Candidate is an Associate Professor (Research) in the Department of Psychiatry and Human Behavior of the Warren Alpert Medical School at Brown University, with a history of funding in behavioral interventions and longitudinal research aimed at improving asthma outcomes in urban children and addressing health disparities in pediatric asthma. Training Plan: The candidate will obtain additional training in asthma clinical immunology and sleep physiology, including state-of the art methods to assess immune biomarkers relevant to asthma and sleep, and in-lab methods to assess sleep phenomenology through experimental approaches. Research Plan: The research proposed involves an innovative investigation of the effects of experimental sleep disruption on immune balance (Th1/Th2 cytokine ratio-Th1/Th2R; plasma IL-6 -pIL-6), and associated changes in asthma- related lung function (FEV1 by spirometry) and daytime performance in urban children with persistent asthma (8-10 years old). Forty children and their primary caregiver will each participate in a within-subjects protocol, with two experimental sleep conditions: baseline sleep (1 overnight, in-lab polysomnographic (PSG) sleep study), followed by sleep fragmentation (1 overnight, in-lab PSG). Prior to each condition, children will follow a 6-day sleep stabilization schedule at home. We will monitor sleep and lung function (FEV1 by spirometry) daily to confirm eligibility and adherence to sleep criteria, and assess asthma status. We include assessments of immune biomarkers and daytime performance following each condition. Results from this study ultimately will support the development of asthma and sleep interventions for urban and ethnically diverse children. Our data will elucidate how immune biomarkers relevant to asthma and sleep operate in relation to sleep disruption, and clinical indicators of worsening asthma (lung function), to identify those most at risk, prioritize intervention targets, and improve treatment response. Mentoring Plan: The proposed mentoring plan offers opportunities for mentorship of postdoctoral fellows, residents and junior faculty with interests in POR. Mentees will be involved in ongoing longitudinal and intervention studies on pediatric asthma disparities, including the proposed research, which will focus on biological-based processes that contribute to asthma and sleep in urban children. A strong emphasis is placed on the recruitment and selection of minority mentees. This overall plan capitalizes on the rich resources and training opportunities available to postdoctoral fellows, residents and junior faculty at Brown Medical School, including several T32 fellowship programs, numerous junior faculty with K awards and small grants, a commitment to diversity in training, seminars in research design, ethics, and statistics, and an established infrastructure for evaluation.