Pathogenesis of Borrelia mayonii infection

马氏疏螺旋体感染的发病机制

• 批准号: 9263401
• 负责人: Brian Stevenson
• 金额: $ 24.83万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-24 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9263401
• 关键词: Address; Affinity; Amino Acids; Antigens; Bacteremia; Bacterial Adhesins; Blood Vessels; Borrelia; Borrelia burgdorferi; Chromosomes, Human, 4-5; Clinical; Complement; Development; Diagnosis; Diffuse; Disease; Employee Strikes; Event; Exanthema; Exhibits; Genes; Genetic; Geography; Goals; Hospitalization; Human; Inbred Mouse; Infection; Lyme Disease; Membrane Proteins; Midwestern United States; Modeling; Molecular; Mus; Myalgia; Neurologic Signs; Orthologous Gene; OspC protein; Pathogenesis; Pathogenicity; Pathologic; Pathology; Patients; Property; Proteins; Proteomics; Public Health; Reporting; Surface Antigens; Symptoms; Tick-Borne Diseases; Ticks; Tissues; Virulence Factors; insight; macula; mouse model; novel; outer surface lipoprotein; pathogen; tool

ABSTRACT Borrelia mayonii is the causative agent of a newly-recognized tick-borne disease. First reported in the upper Midwest during February, 2016, the geographic range of this emerging public health threat is not yet known. Although B. mayonii is related to the classic Lyme disease agent, Borrelia burgdorferi, the two species exhibit substantial genetic differences. We hypothesize that those differences are responsible for the distinct features of B. mayonii infection. A striking difference between the two diseases is the high spirochetemia that has been observed only in patients infected with B. mayonii. Other symptoms of B. mayonii infection include macular rashes across the body, myalgia, and neurological signs, with some patients requiring hospitalization. Three critical questions about B. mayonii and its associated disease are being addressed by our studies: (1) What are the extents of spirochetemia, tissue pathology, and other infectious qualities in untreated mammalian B. mayonii infection? (2) What is responsible for the high-level spirochetemia that occurs during B. mayonii infection, but not during B. burgdorferi infection? and (3) What antigenic proteins are produced during B. mayonii infection, but not during B. burgdorferi infection, that can be used for diagnosis of this emerging disease? Results from our studies will provide valuable insight on the pathogenic properties of B. mayonii and lay important groundwork for diagnosis and treatment.

抽象的 马约氏疏螺旋体是一种新发现的蜱传疾病的病原体。最先报道于上层 2016 年 2 月期间，中西部地区这一新兴公共卫生威胁的地理范围尚不清楚。 尽管马约氏疏螺旋体与经典的莱姆病病原体伯氏疏螺旋体 (Borrelia burgdorferi) 有亲缘关系，但这两个物种表现出 显着的遗传差异。我们假设这些差异导致了不同的特征 马约尼芽孢杆菌感染。这两种疾病之间的一个显着区别是高螺旋体血症 仅在感染马约尼芽孢杆菌的患者中观察到。马约尼芽孢杆菌感染的其他症状包括黄斑 全身出现皮疹、肌痛和神经系统症状，一些患者需要住院治疗。三 我们的研究正在解决有关马约伯伯氏菌及其相关疾病的关键问题：（1）什么 是未经治疗的哺乳动物B.螺旋体血症、组织病理学和其他传染性的程度。 马约尼感染？ (2) 是什么原因导致 B. mayonii 期间发生高水平螺旋体血症 感染，但不是在伯氏疏螺旋体感染期间？ (3) B.过程中产生了哪些抗原蛋白。 mayonii 感染，但不在伯氏疏螺旋体感染期间，可用于诊断这种新出现的疾病 疾病？我们的研究结果将为了解 B. mayonii 的致病特性和 为诊断和治疗奠定重要基础。