Pathogenesis of Borrelia mayonii infection
Pathogenesis of Borrelia mayonii infection
批准号:
9263401
负责人:
Brian Stevenson
金额:
$24.83万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-07-24 至 2019-06-30
关键词:
AddressAffinityAmino AcidsAntigensBacteremiaBacterial AdhesinsBlood VesselsBorreliaBorrelia burgdorferiChromosomes, Human, 4-5ClinicalComplementDevelopmentDiagnosisDiffuseDiseaseEmployee StrikesEventExanthemaExhibitsGenesGeneticGeographyGoalsHospitalizationHumanInbred MouseInfectionLyme DiseaseMembrane ProteinsMidwestern United StatesModelingMolecularMusMyalgiaNeurologic SignsOrthologous GeneOspC proteinPathogenesisPathogenicityPathologicPathologyPatientsPropertyProteinsProteomicsPublic HealthReportingSurface AntigensSymptomsTick-Borne DiseasesTicksTissuesVirulence Factorsinsightmaculamouse modelnovelouter surface lipoproteinpathogentool
中文摘要
摘要
梅氏疏螺旋体是一种新发现的壁虱传播疾病的病原体。最早在上边报道
中西部2016年2月,这一新兴公共卫生威胁的地理范围尚不清楚。
尽管马约氏杆菌与典型的莱姆病病原体伯氏疏螺旋体有亲缘关系,但这两个物种表现出
巨大的遗传差异。我们假设,这些差异是导致这些不同特征的原因
感染马约氏巴氏杆菌。这两种疾病之间的一个显著区别是高螺旋体血症
仅在感染马约氏杆菌的患者中观察到。感染马约氏巴氏杆菌的其他症状包括黄斑
全身出现皮疹、肌肉疼痛和神经体征,一些患者需要住院治疗。三
我们的研究正在解决有关马约氏杆菌及其相关疾病的关键问题:(1)什么
未经治疗的哺乳动物B.螺旋体血症的程度、组织病理学和其他感染性特征。
马约氏杆菌感染?(2)在马约氏杆菌感染期间发生的高水平螺旋体血症是什么原因?
感染,但不是在伯氏杆菌感染期间?(3)B期产生了哪些抗原蛋白。
而不是在伯氏杆菌感染期间,这可用于诊断这种新出现的疾病
疾病?我们的研究结果将为了解马约氏杆菌的致病特性和
为诊断和治疗奠定重要基础。
英文摘要
ABSTRACT
Borrelia mayonii is the causative agent of a newly-recognized tick-borne disease. First reported in the upper
Midwest during February, 2016, the geographic range of this emerging public health threat is not yet known.
Although B. mayonii is related to the classic Lyme disease agent, Borrelia burgdorferi, the two species exhibit
substantial genetic differences. We hypothesize that those differences are responsible for the distinct features
of B. mayonii infection. A striking difference between the two diseases is the high spirochetemia that has been
observed only in patients infected with B. mayonii. Other symptoms of B. mayonii infection include macular
rashes across the body, myalgia, and neurological signs, with some patients requiring hospitalization. Three
critical questions about B. mayonii and its associated disease are being addressed by our studies: (1) What
are the extents of spirochetemia, tissue pathology, and other infectious qualities in untreated mammalian B.
mayonii infection? (2) What is responsible for the high-level spirochetemia that occurs during B. mayonii
infection, but not during B. burgdorferi infection? and (3) What antigenic proteins are produced during B.
mayonii infection, but not during B. burgdorferi infection, that can be used for diagnosis of this emerging
disease? Results from our studies will provide valuable insight on the pathogenic properties of B. mayonii and
lay important groundwork for diagnosis and treatment.
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财政年份:2020
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SpoVG and PlzA Regulation of Lyme Disease Spirochete Infection Processes
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依托单位:
Borrelia miyamotoi: mechanisms of tick colonization and transmission
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Bpur, a critical regulator of Borrelia burgdorferi infectivity
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批准号:9220718
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资助金额:$18.53万
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财政年份:2016
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负责人:Brian Stevenson
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依托单位:
Borrelia miyamotoi: mechanisms of tick colonization and transmission
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批准号:9196769
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项目类别:
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资助金额:$23.95万
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财政年份:2016
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负责人:Brian Stevenson
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依托单位:
The Borrelia burgdorferi transcriptional regulome
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批准号:8771024
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依托单位:
Borrelia burdorferi Ebfc regulon
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批准号:8675800
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资助金额:$18.75万
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财政年份:2013
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负责人:Brian Stevenson
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依托单位:
Borrelia burdorferi Ebfc regulon
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批准号:8598380
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资助金额:$15.53万
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财政年份:2013
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依托单位:
CRASP-2 proteins of Lyme disease Borrelia
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负责人:Brian Stevenson
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依托单位:
CRASP-2 proteins of Lyme disease Borrelia
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批准号:7842617
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项目类别:
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资助金额:$18.31万
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财政年份:2009
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Leptospira interrogans Len adhesins
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资助金额:$21.98万
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负责人:Brian Stevenson
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依托单位:
Leptospira interrogans Len adhesins
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批准号:7641104
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资助金额:$18.31万
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财政年份:2008
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负责人:Brian Stevenson
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Borrelia burgdorferi LuxS-mediated quorum sensing
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依托单位:
Borrelia burgdorferi LuxS-mediated quorum sensing
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海外基金