Pathogenesis of Borrelia mayonii infection
马氏疏螺旋体感染的发病机制
基本信息
- 批准号:9263401
- 负责人:
- 金额:$ 24.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-24 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffinityAmino AcidsAntigensBacteremiaBacterial AdhesinsBlood VesselsBorreliaBorrelia burgdorferiChromosomes, Human, 4-5ClinicalComplementDevelopmentDiagnosisDiffuseDiseaseEmployee StrikesEventExanthemaExhibitsGenesGeneticGeographyGoalsHospitalizationHumanInbred MouseInfectionLyme DiseaseMembrane ProteinsMidwestern United StatesModelingMolecularMusMyalgiaNeurologic SignsOrthologous GeneOspC proteinPathogenesisPathogenicityPathologicPathologyPatientsPropertyProteinsProteomicsPublic HealthReportingSurface AntigensSymptomsTick-Borne DiseasesTicksTissuesVirulence Factorsinsightmaculamouse modelnovelouter surface lipoproteinpathogentool
项目摘要
ABSTRACT
Borrelia mayonii is the causative agent of a newly-recognized tick-borne disease. First reported in the upper
Midwest during February, 2016, the geographic range of this emerging public health threat is not yet known.
Although B. mayonii is related to the classic Lyme disease agent, Borrelia burgdorferi, the two species exhibit
substantial genetic differences. We hypothesize that those differences are responsible for the distinct features
of B. mayonii infection. A striking difference between the two diseases is the high spirochetemia that has been
observed only in patients infected with B. mayonii. Other symptoms of B. mayonii infection include macular
rashes across the body, myalgia, and neurological signs, with some patients requiring hospitalization. Three
critical questions about B. mayonii and its associated disease are being addressed by our studies: (1) What
are the extents of spirochetemia, tissue pathology, and other infectious qualities in untreated mammalian B.
mayonii infection? (2) What is responsible for the high-level spirochetemia that occurs during B. mayonii
infection, but not during B. burgdorferi infection? and (3) What antigenic proteins are produced during B.
mayonii infection, but not during B. burgdorferi infection, that can be used for diagnosis of this emerging
disease? Results from our studies will provide valuable insight on the pathogenic properties of B. mayonii and
lay important groundwork for diagnosis and treatment.
抽象的
马约氏疏螺旋体是一种新发现的蜱传疾病的病原体。最先报道于上层
2016 年 2 月期间,中西部地区这一新兴公共卫生威胁的地理范围尚不清楚。
尽管马约氏疏螺旋体与经典的莱姆病病原体伯氏疏螺旋体 (Borrelia burgdorferi) 有亲缘关系,但这两个物种表现出
显着的遗传差异。我们假设这些差异导致了不同的特征
马约尼芽孢杆菌感染。这两种疾病之间的一个显着区别是高螺旋体血症
仅在感染马约尼芽孢杆菌的患者中观察到。马约尼芽孢杆菌感染的其他症状包括黄斑
全身出现皮疹、肌痛和神经系统症状,一些患者需要住院治疗。三
我们的研究正在解决有关马约伯伯氏菌及其相关疾病的关键问题:(1)什么
是未经治疗的哺乳动物B.螺旋体血症、组织病理学和其他传染性的程度。
马约尼感染? (2) 是什么原因导致 B. mayonii 期间发生高水平螺旋体血症
感染,但不是在伯氏疏螺旋体感染期间? (3) B.过程中产生了哪些抗原蛋白。
mayonii 感染,但不在伯氏疏螺旋体感染期间,可用于诊断这种新出现的疾病
疾病?我们的研究结果将为了解 B. mayonii 的致病特性和
为诊断和治疗奠定重要基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brian Stevenson其他文献
Brian Stevenson的其他文献
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{{ truncateString('Brian Stevenson', 18)}}的其他基金
Improving Vocational Outcomes of Veterans with Psychiatric Disorders: Career Counseling & Development
改善患有精神疾病的退伍军人的职业成果:职业咨询
- 批准号:
10604333 - 财政年份:2021
- 资助金额:
$ 24.83万 - 项目类别:
Improving Vocational Outcomes of Veterans with Psychiatric Disorders: Career Counseling & Development
改善患有精神疾病的退伍军人的职业成果:职业咨询
- 批准号:
10187223 - 财政年份:2021
- 资助金额:
$ 24.83万 - 项目类别:
Improving Vocational Outcomes of Veterans with Psychiatric Disorders: Career Counseling & Development
改善患有精神疾病的退伍军人的职业成果:职业咨询
- 批准号:
10391341 - 财政年份:2021
- 资助金额:
$ 24.83万 - 项目类别:
SpoVG and PlzA Regulation of Lyme Disease Spirochete Infection Processes
SpoVG 和 PlzA 对莱姆病螺旋体感染过程的调节
- 批准号:
10597629 - 财政年份:2020
- 资助金额:
$ 24.83万 - 项目类别:
SpoVG and PlzA Regulation of Lyme Disease Spirochete Infection Processes
SpoVG 和 PlzA 对莱姆病螺旋体感染过程的调节
- 批准号:
9885360 - 财政年份:2020
- 资助金额:
$ 24.83万 - 项目类别:
SpoVG and PlzA Regulation of Lyme Disease Spirochete Infection Processes
SpoVG 和 PlzA 对莱姆病螺旋体感染过程的调节
- 批准号:
10682908 - 财政年份:2020
- 资助金额:
$ 24.83万 - 项目类别:
SpoVG and PlzA Regulation of Lyme Disease Spirochete Infection Processes
SpoVG 和 PlzA 对莱姆病螺旋体感染过程的调节
- 批准号:
10372949 - 财政年份:2020
- 资助金额:
$ 24.83万 - 项目类别:
Borrelia burgdorferi responses to antibiotic stresses
伯氏疏螺旋体对抗生素应激的反应
- 批准号:
9374989 - 财政年份:2017
- 资助金额:
$ 24.83万 - 项目类别:
Borrelia miyamotoi: mechanisms of tick colonization and transmission
宫本伯氏疏螺旋体:蜱的定植和传播机制
- 批准号:
9297214 - 财政年份:2016
- 资助金额:
$ 24.83万 - 项目类别:
Bpur, a critical regulator of Borrelia burgdorferi infectivity
Bpur,伯氏疏螺旋体感染性的关键调节因子
- 批准号:
9220718 - 财政年份:2016
- 资助金额:
$ 24.83万 - 项目类别:
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