Midcareer Investigator Award in Patient-Oriented Research in Human Hypertension

人类高血压以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 9207780
• 负责人: DAICHI SHIMBO
• 金额: $ 11.48万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9207780
• 关键词: Acute; Adult; Affect; Ambulatory Blood Pressure Monitoring; Anger; Angiotensin II; Antihypertensive Agents; Area; Behavior; Behavioral; Biological; Biological Process; Blood Pressure; Cardiovascular Diseases; Clinical; Communities; Competence; Data; Development; Discipline; Eating; Ecological momentary assessment; Enrollment; Ensure; Environment; Equilibrium; Evaluation; Event; Excretory function; Exposure to; Feasibility Studies; Future; Goals; Grant; Home Blood Pressure Monitoring; Hostility; Hour; Human; Hypertension; Impairment; Individual; Intake; International; Intervention; K-Series Research Career Programs; Kidney; Knowledge; Laboratories; Lead; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Monitor; Natriuresis; Needs Assessment; Participant; Pathogenesis; Pathway interactions; Pattern; Pharmaceutical Preparations; Phenotype; Pilot Projects; Process; Productivity; Psyche structure; Psychological Stress; Psychosocial Factor; Psychosocial Stress; Public Health; Recording of previous events; Recruitment Activity; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Research Training; Sampling; Scientist; Social support; Sodium; Sodium Chloride; Stress; Testing; Training; Training Activity; Training Programs; Urine; Writing; blood pressure reduction; blood pressure regulation; cardiovascular disorder risk; cardiovascular risk factor; career; design; dissemination research; experience; experimental study; innovation; interest; mortality; next generation; novel; patient oriented research; personalized approach; pressure; programs; psychosocial; public health relevance; racism; research data dissemination; response; screening; skills training; stressor; synergism; trait; urinary

 DESCRIPTION (provided by applicant): Career Objectives: My overall career plan is to expand my research interests to understanding the behavioral, psychosocial and biological processes in the pathogenesis of human hypertension, and to develop and test novel interventions to affect these processes. My short-term career goals are to (1) become a national and international leader in mechanistic research in behavioral and psychosocial aspects of hypertension, (2) to gain expertise in renal sodium excretion and its relation with blood pressure (BP) which will advance my programmatic research in examining the effect of stress on hypertension, (3) to transform my laboratory into a local, regional, and national center of excellence for ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM), and (4) to implement an outstanding training program in patient-oriented research in hypertension for young investigators. Mentoring Plan: A central component of my mentoring program is an individualized approach to training, which includes a needs assessment of core research competencies and an ongoing intensive evaluation process. During the training period, each of my mentees will undergo several training modules, the content of which will be tailored to each mentee's needs: Didactics; Focused Skills Training; Applied, Hands-on Training & Team Management; Research Dissemination; and Grant Writing and Study Development. Research Strategy and Synergy with My Career Objectives and Mentoring Plan: Nocturnal hypertension (nighttime BP e120/70 mmHg) or a non-dipping BP pattern (d10% reduction in BP at night), determined by ABPM, are associated with an increased risk of cardiovascular events and mortality. Using the new knowledge that I will gain from my training in psychosocial factors and behavior and clinical and biological aspects of hypertension, and training in sodium excretion, I will conduct an innovative pilot study to examine whether a novel psychosocial stress pathway, reduced urinary sodium excretion, partially explains the relation between psychosocial stress and elevated nighttime BP. The state-of-the-art study will be conducted in the laboratory setting and in the natural environment in the same participants (N=100) in Years 1-3. In addition to gathering preliminary data for a future R01 application, the study will serve as a platform for my mentees' research training. Two additional mentee-specific pilot studies will be conducted in Years 4 and 5 respectively. The overall aims of these studies are to have a mentee gain practical experience in conducting a study in a specific area of hypertension that matches his/her career goals; and to obtain preliminary data so that the mentee is able to submit a K Award or a R01 application the following year. Summary: My strong commitment to patient-oriented research in hypertension, an individualized mentorship plan, direct involvement of the mentees in the conduct of patient-oriented studies in hypertension, availability of experts in different disciplines as co-mentors, as well as outstanding institutional support are all strengths that will ensure that my mentees have strong research productivity in hypertension and also eventually become independent scientists.

 职业描述(申请人提供)：职业目标：我的整个职业生涯计划是扩大我的研究兴趣，以了解人类高血压发病机制中的行为、心理社会和生物学过程，并开发和测试影响这些过程的新干预措施。我的短期职业目标是(1)成为高血压行为和心理社会方面的机械研究的国内和国际领导者，(2)获得肾脏钠排泄及其与血压(BP)的关系方面的专业知识，这将推动我在研究压力对高血压的影响方面的程序性研究，(3)将我的实验室转变为当地、地区和全国的动态血压监测(ABPM)和家庭血压监测(HBPM)卓越中心，以及(4)实施面向年轻研究人员的以患者为导向的高血压研究方面的杰出培训计划。指导计划：我的指导计划的一个核心组成部分是个性化的培训方法，其中包括对核心研究能力的需求评估和持续的密集评估过程。在培训期间，我的每个学员将接受几个培训模块，培训内容将根据每个学员的需求量身定做：教学；重点技能培训；应用、动手培训和团队管理；研究传播；以及助学金编写和学习发展。研究策略以及与我的职业目标和指导计划的协同性：ABPM确定的夜间高血压(夜间血压E120/70毫米汞柱)或非低血压模式(夜间血压下降10%)与心血管事件和死亡率的增加相关。利用我在心理社会因素和高血压的行为、临床和生物学方面的培训以及钠排泄方面的培训所获得的新知识，我将进行一项创新的试点研究，以检验一种新的心理社会应激途径--减少尿钠排泄--是否部分解释了心理社会应激与夜间血压升高之间的关系。这项最先进的研究将在1-3年内在实验室环境和自然环境中对相同的参与者(N=100)进行。除了为未来的R01应用收集初步数据外，这项研究还将作为我的学员进行研究培训的平台。另外两项针对学员的试点研究将分别在第4年和第5年进行。这些研究的总体目标是让受训者获得在特定领域进行与其职业目标相匹配的高血压研究的实际经验；并获得初步数据，以便受训者能够在下一年提交K奖或R01申请。摘要：我对以病人为本的高血压研究的坚定承诺，一个个性化的导师计划，被辅导者直接参与以病人为导向的高血压研究，不同学科的专家作为共同导师的可用性，以及出色的机构支持，这些都是我的优势。 这将确保我的受训者在高血压方面拥有强大的研究生产力，并最终成为独立的科学家。