Midcareer Investigator Award in Patient-Oriented Research in Human Hypertension

人类高血压以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 8998057
• 负责人: DAICHI SHIMBO
• 金额: $ 11.3万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8998057
• 关键词: Acute; Adult; Affect; Ambulatory Blood Pressure Monitoring; Anger; Angiotensin II; Antihypertensive Agents; Area; Behavior; Behavioral; Biological; Biological Process; Blood Pressure; Cardiovascular Diseases; Clinical; Communities; Data; Development; Discipline; Eating; Ecological momentary assessment; Enrollment; Ensure; Environment; Equilibrium; Evaluation; Event; Excretory function; Exposure to; Feasibility Studies; Future; Goals; Grant; Health; Home Blood Pressure Monitoring; Hostility; Hour; Human; Hypertension; Individual; Intake; International; Intervention; K-Series Research Career Programs; Kidney; Knowledge; Laboratories; Lead; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Monitor; Natriuresis; Needs Assessment; Participant; Pathogenesis; Pathway interactions; Pattern; Pharmaceutical Preparations; Phenotype; Pilot Projects; Process; Productivity; Psyche structure; Psychological Stress; Psychosocial Factor; Psychosocial Stress; Public Health; Recording of previous events; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Research Training; Risk Factors; Sampling; Scientist; Social support; Sodium; Sodium Chloride; Stress; Testing; Training; Training Activity; Training Programs; Urine; Writing; blood pressure reduction; blood pressure regulation; cardiovascular disorder risk; cardiovascular risk factor; career; design; experience; innovation; interest; mortality; next generation; novel; patient oriented research; personalized approach; pressure; programs; psychosocial; racism; research data dissemination; research study; response; screening; skills training; stressor; trait; urinary

 DESCRIPTION (provided by applicant): Career Objectives: My overall career plan is to expand my research interests to understanding the behavioral, psychosocial and biological processes in the pathogenesis of human hypertension, and to develop and test novel interventions to affect these processes. My short-term career goals are to (1) become a national and international leader in mechanistic research in behavioral and psychosocial aspects of hypertension, (2) to gain expertise in renal sodium excretion and its relation with blood pressure (BP) which will advance my programmatic research in examining the effect of stress on hypertension, (3) to transform my laboratory into a local, regional, and national center of excellence for ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM), and (4) to implement an outstanding training program in patient-oriented research in hypertension for young investigators. Mentoring Plan: A central component of my mentoring program is an individualized approach to training, which includes a needs assessment of core research competencies and an ongoing intensive evaluation process. During the training period, each of my mentees will undergo several training modules, the content of which will be tailored to each mentee's needs: Didactics; Focused Skills Training; Applied, Hands-on Training & Team Management; Research Dissemination; and Grant Writing and Study Development. Research Strategy and Synergy with My Career Objectives and Mentoring Plan: Nocturnal hypertension (nighttime BP e120/70 mmHg) or a non-dipping BP pattern (d10% reduction in BP at night), determined by ABPM, are associated with an increased risk of cardiovascular events and mortality. Using the new knowledge that I will gain from my training in psychosocial factors and behavior and clinical and biological aspects of hypertension, and training in sodium excretion, I will conduct an innovative pilot study to examine whether a novel psychosocial stress pathway, reduced urinary sodium excretion, partially explains the relation between psychosocial stress and elevated nighttime BP. The state-of-the-art study will be conducted in the laboratory setting and in the natural environment in the same participants (N=100) in Years 1-3. In addition to gathering preliminary data for a future R01 application, the study will serve as a platform for my mentees' research training. Two additional mentee-specific pilot studies will be conducted in Years 4 and 5 respectively. The overall aims of these studies are to have a mentee gain practical experience in conducting a study in a specific area of hypertension that matches his/her career goals; and to obtain preliminary data so that the mentee is able to submit a K Award or a R01 application the following year. Summary: My strong commitment to patient-oriented research in hypertension, an individualized mentorship plan, direct involvement of the mentees in the conduct of patient-oriented studies in hypertension, availability of experts in different disciplines as co-mentors, as well as outstanding institutional support are all strengths that will ensure that my mentees have strong research productivity in hypertension and also eventually become independent scientists.