Core C- Molecular Regulation of Stem Cell Aging, Bioinformatics Core

核心C-干细胞衰老的分子调控，生物信息学核心

• 批准号: 9211410
• 负责人: Charles Yang Lin
• 金额: $ 14.18万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9211410
• 关键词: Address; Aging; Bioinformatics; Cell Aging; Cell Count; Chromatin; Code; Collaborations; Communities; Computer Analysis; Computer software; Custom; DNA Methylation; DNA Sequencing Facility; Dana-Farber Cancer Institute; Data; Data Analyses; Data Quality; Data Security; Data Set; Data Storage and Retrieval; Databases; Descriptor; Development; Ensure; Environment; Epigenetic Process; Face; Gene Expression; Genetic Transcription; Genome; Genomics; Goals; Hybrids; Imagery; Individual; Institutes; Institution; Language; Lead; Link; Maps; Medicine; Molecular; Online Systems; Play; Process; Publishing; Pythons; Regulation; Repetitive Sequence; Reproducibility; Research; Research Personnel; Resources; Role; Secure; Security; Software Engineering; Standardization; Stem cells; System; Techniques; United States National Institutes of Health; Universities; age related; application programming interface; base; college; computerized data processing; data sharing; data visualization; epigenetic regulation; epigenome; high dimensionality; improved; innovation; interoperability; next generation sequencing; novel; novel strategies; open source; power analysis; programs; single molecule; software development; tool

SUMMARY There is a shared need for genomic and other high dimensional data analysis among project investigators. The Bioinformatics Core will establish a centralized, intelligent and robust computational platform for high dimensional data analysis powered by a well-developed open source software code base that will integrate novel techniques to more quantitatively map chromatin and epigenetic changes during aging. To accelerate the computational aims of this Program Project, the Core will lead a collaborative endeavor 1) to improve data accessibility and security by implementing a NIH and GEO compliant database solution, 2) to promote bioinformatics collaboration and reproducibility by implementing an application programming interface (API) that interconnects analysis software and establishes a shared and well documented development and analysis language, and 3) to enable facile data exploration and interpretation by creating web based portals for project specific data analysis and visualization. Through these Aims, this central resource for the Molecular Regulation of Stem Cell Aging Program Project will promote intra-lab interactions and coordinate high dimensional data analysis to help meet the broader goals of better understanding the epigenetic regulation of aging in stem cells.

总结 项目之间对基因组和其他高维数据分析有共同的需求， investigators.生物信息学核心将建立一个集中的，智能的和强大的 一个用于高维数据分析的计算平台， 源软件代码库，将集成新技术以更定量地映射 染色质和表观遗传学的变化。为了加速这一计算目标， 计划项目，核心将领导一项合作奋进1）提高数据的可访问性， 通过实施符合NIH和GEO标准的数据库解决方案来实现安全性，2）促进 通过实施应用程序编程实现生物信息学协作和再现性 接口（API），其互连分析软件并建立共享和良好的 文档化的开发和分析语言，以及3）实现轻松的数据探索， 通过创建基于Web的门户网站进行项目特定数据分析和可视化。 通过这些目标，这一核心资源的干细胞衰老的分子调控 计划项目将促进实验室内部的互动和协调高维数据 分析，以帮助实现更好地了解表观遗传调控的更广泛的目标， 干细胞衰老