Core C- Molecular Regulation of Stem Cell Aging, Bioinformatics Core

摘要 在项目之间存在对基因组和其他高维数据分析的共同需求 调查人员。生物信息学核心将建立一个集中、智能和强大的 基于成熟开放平台的高维数据分析计算平台 源代码软件代码库，将集成新技术以更定量地绘制地图 染色质和表观遗传学在衰老过程中的变化。要加速此计算目标， 计划项目，核心将领导合作努力1)改善数据可访问性和 通过实施符合NIH和GEO的数据库解决方案来提高安全性，2)促进 通过实施应用程序编程实现生物信息学协作和重现性 接口(API)，用于互连分析软件并建立共享和良好的 文档化的开发和分析语言，以及3)实现便捷的数据探索和 通过创建基于Web的门户网站进行解释，用于特定项目的数据分析和可视化。 通过这些目标，干细胞衰老分子调控的中心资源 计划项目将促进实验室内部交互并协调高维数据 分析有助于实现更好地理解表观遗传调控的更广泛目标 干细胞中的衰老。

SUMMARY There is a shared need for genomic and other high dimensional data analysis among project investigators. The Bioinformatics Core will establish a centralized, intelligent and robust computational platform for high dimensional data analysis powered by a well-developed open source software code base that will integrate novel techniques to more quantitatively map chromatin and epigenetic changes during aging. To accelerate the computational aims of this Program Project, the Core will lead a collaborative endeavor 1) to improve data accessibility and security by implementing a NIH and GEO compliant database solution, 2) to promote bioinformatics collaboration and reproducibility by implementing an application programming interface (API) that interconnects analysis software and establishes a shared and well documented development and analysis language, and 3) to enable facile data exploration and interpretation by creating web based portals for project specific data analysis and visualization. Through these Aims, this central resource for the Molecular Regulation of Stem Cell Aging Program Project will promote intra-lab interactions and coordinate high dimensional data analysis to help meet the broader goals of better understanding the epigenetic regulation of aging in stem cells.