Super-harmonic ultrasonic imaging of the coronary artery

冠状动脉超谐波超声成像

• 批准号: 9383331
• 负责人: Marvin M Doyley
• 金额: $ 22.98万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9383331
• 关键词: Acoustics; Address; Atherosclerosis; Blood Vessels; Cardiovascular Agents; Cardiovascular Diseases; Carotid Arteries; Catheters; Clinical; Clinical Trials; Coronary; Coronary artery; Coupling; Detection; Devices; Disease; Effectiveness; Elements; Embryo; Frequencies; Goals; Growth; Hybrids; Hyperplasia; Image; Individual; Life; Magnetic Resonance Imaging; Measures; Methods; Microbubbles Ultrasound Contrast Medium; Modeling; Myocardial Infarction; Nutrient; Optics; Patient risk; Performance; Procedures; Proliferating; Research; Research Personnel; Resolution; Risk; Rupture; Signal Transduction; Stroke; Structure; Techniques; Technology; Testing; Tissues; Transducers; Ultrasonic Transducer; Ultrasonography; United States; Vertebral column; aging population; cardiovascular imaging; clinical application; contrast enhanced; density; design; high risk; novel; novel strategies; optical sensor; preclinical trial; pressure; prevent; prototype; quantitative ultrasound; second harmonic; sensor; silicon carbide; sudden cardiac death; vasa vasorum

The increase in cardiovascular disease in the United States has created a need for methods that can screen high-risk patients for life-threatening plaques and assess the effectiveness of new cardiovascular drugs. Abnormal proliferation of the vasa vasorum in diseased vessels may promote the progression of atherosclerosis and increase the propensity of plaque rupture. Consequently, we and others are actively developing methods for visualizing the vasa vasorum. Contrast-enhanced ultrasound (CEU) imaging is frequently used to visualize the vasa vasorum within the carotid artery; however, the lack of sensitive high frequency broadband catheters has prevented researchers from advancing CEU to the smaller coronary artery. To overcome this technological challenge, we plan to use the principle of optomechanical transduction to develop high-performance (sensitive and broadband) tunable ultrasound catheters. Specifically, we will design and fabricate a novel high quality optomechanical resonator from silicon carbide (Aim 1). This optomechanical resonator will form the backbone of a tunable ultrasound transducer that we plan to develop (Aim 2). We will use the optomechanical resonator to detect harmonic signals (subharmonic, fundamental, second harmonic, ultra-harmonic, and super-harmonic) emitted when microbubble ultrasound contrast agents are excited with a 20 MHz piezoelectric transducer. We plan to perform phantom studies to evaluate the performance of the integrated optomechanical/piezoelectric transducer. We will use an embryonic chick model to assess the sensitivity of harmonic images created with the proposed integrated optomechanical/piezoelectric transducer and dual frequency transducers (a competing technology) to changes in vessel size and density. If successful, the proposed technology could revolutionize ultrasonic imaging by providing a novel approach for fabricating reliable broadband transducers desired by several clinical applications. Additionally, the proposed research represents a critical step towards establishing vasa vasorum imaging as a technique for evaluating the efficacy of new cardiovascular drugs.

美国心血管疾病的增加创造了对可以筛查的方法的需求 高危患者的危及生命的斑块，并评估新的心血管药物的有效性。 病变血管中血管小血管的异常增生可能促进血管病变的进展， 动脉粥样硬化和增加斑块破裂的倾向。因此，我们和其他人正在积极 开发用于可视化血管的方法。对比增强超声（CEU）成像是 经常用于显示颈动脉内的血管;然而，缺乏敏感的高分辨率， 高频宽带导管阻碍了研究人员将CEU推进到较小的冠状动脉。 为了克服这一技术挑战，我们计划利用光机械转换的原理， 开发高性能（灵敏度和宽带）可调超声导管。具体来说，我们将设计 并利用碳化硅材料制作了一种新型的高质量光机械谐振器（Aim 1）。此光学机械 谐振器将形成我们计划开发的可调谐超声换能器的支柱（目标2）。我们将 使用光机械谐振器检测谐波信号（次谐波，基波，二次谐波， 超谐波和超谐波），当微泡超声造影剂用 20 MHz压电换能器。我们计划进行体模研究，以评估 集成光学机械/压电换能器。我们将使用鸡胚模型来评估 用所提出的集成光机械/压电换能器产生的谐波图像的灵敏度 和双频传感器（竞争技术）以适应血管尺寸和密度的变化。如果成功， 所提出的技术可以通过提供一种新颖的制造方法来彻底改变超声成像， 几种临床应用所需的可靠宽带换能器。此外，拟议的研究 代表了建立血管成像作为评价疗效的技术的关键一步 新的心血管药物。