Cytokine regulation of T follicular helper (Tfh) cell biology

摘要 滤泡辅助性T细胞（Tfh）是体液免疫的核心参与者。然而，参与诱导， 指导和维持人Tfh分化的机制知之甚少。在这个提案中，我们展示了 鉴定人Tfh分化的新调节剂的初步数据。我们建议验证这些 研究结果，确定这些调节剂的分子作用机制，并制定一个综合的过程 用于诱导和调节人Tfh细胞分化。

Abstract T follicular helper cells (Tfh) are central players in humoral immunity. However, the signals involved in inducing, directing, and maintaining human Tfh differentiation are poorly understood. In this proposal we show preliminary data identifying novel regulators of human Tfh differentiation. We proposal to validate these findings, identify the molecular mechanisms of action of these regulators, and develop an integrated process for inducing and regulating human Tfh cell differentiation.