Cytokine regulation of T follicular helper (Tfh) cell biology

滤泡辅助 T (Tfh) 细胞生物学的细胞因子调节

• 批准号: 10217961
• 负责人: Michela Locci
• 金额: $ 40.25万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10217961
• 关键词: ATAC-seq; Activins; Address; Affinity; Antibody Response; Autoantibodies; Autoimmune Diseases; Automobile Driving; B cell differentiation; B-Lymphocytes; BLR1 gene; Biology; CD4 Positive T Lymphocytes; CXCL13 gene; Cell Differentiation process; Cell physiology; Cells; Cellular biology; ChIP-seq; Complex; Cytokine Network Pathway; Data; Development; Evaluation; Family; Fostering; Generations; Genes; Goals; Government; Helper-Inducer T-Lymphocyte; Homeostasis; Human; Humoral Immunities; In Vitro; Individual; Institutes; Instruction; Interferon Type I; Interferons; Interleukin-12; Interleukin-2; Light; MADH2 gene; MADH3 gene; Mature B-Lymphocyte; Mediating; Mediator of activation protein; Memory B-Lymphocyte; Molds; Molecular; Molecular Mechanisms of Action; Mus; Pathway interactions; Patients; Persons; Pharmacology; Physiological; Plasma Cells; Process; Regulation; Rheumatoid Arthritis; Role; STAT4 gene; Shapes; Signal Pathway; Signal Transduction; Site; TNF gene; Vaccination; activin A; cytokine; genetic signature; in vivo; inhibitor/antagonist; member; novel; pathogen; programmed cell death protein 1; programs; receptor; response; synergism; transcriptome sequencing

Abstract T follicular helper cells (Tfh) are central players in humoral immunity. However, the signals involved in inducing, directing, and maintaining human Tfh differentiation are poorly understood. In this proposal we show preliminary data identifying novel regulators of human Tfh differentiation. We proposal to validate these findings, identify the molecular mechanisms of action of these regulators, and develop an integrated process for inducing and regulating human Tfh cell differentiation.

抽象的 T卵泡辅助细胞（TFH）是体液免疫中的核心参与者。但是，涉及诱导的信号， 引导和维持人类TFH分化的理解很少。在这个建议中，我们显示 初步数据鉴定了人类TFH分化的新调节因子。我们建议验证这些 调查结果，确定这些调节剂的作用分子机制，并开发一个综合过程 用于诱导和调节人类TFH细胞分化。

项目成果

SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and Beyond.

• DOI: 10.3390/vaccines9020147
• 发表时间: 2021-02-12
• 期刊: Vaccines
• 影响因子: 7.8
• 作者: Bettini E;Locci M
• 通讯作者: Locci M