Cytokine regulation of T follicular helper (Tfh) cell biology

摘要 T滤泡辅助细胞(TFH)是体液免疫的核心细胞。然而，诱导过程中涉及的信号， 人们对指导和维持人类Tfh的分化知之甚少。在这份提案中，我们展示了 鉴定人类转铁蛋白分化的新调控因子的初步数据。我们建议对这些数据进行验证 发现，确定这些调节剂的分子作用机制，并开发一个完整的过程 用于诱导和调节人Tfh细胞分化。

Abstract T follicular helper cells (Tfh) are central players in humoral immunity. However, the signals involved in inducing, directing, and maintaining human Tfh differentiation are poorly understood. In this proposal we show preliminary data identifying novel regulators of human Tfh differentiation. We proposal to validate these findings, identify the molecular mechanisms of action of these regulators, and develop an integrated process for inducing and regulating human Tfh cell differentiation.